Type 1 diabetes mellitus research hub
14 indexed studies · 6 currently recruiting
- ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A research study of a new medicine NNC0363-1063 in healthy participants and participants with type 1 diabetes
This study is looking into a new medicine called NNC0363-1063 for people with type 1 diabetes and healthy individuals. It's the very first time this medicine is being given to humans, to see how it works and if it's safe.
Germany - recruitingPHASE3
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
This study is looking at a new medicine called Teplizumab for people aged 1 to 25 with a recent diagnosis of Stage 3 Type 1 Diabetes. It compares Teplizumab to a dummy medicine to see if it makes managing blood sugar easier and reduces how much insulin they need.
United States · Argentina · Australia - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Trial to Evaluate the Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Insulin GZR33 Compared with Insulin Degludec at steady state in participants with Type 1 Diabetes
This study is comparing a new insulin, GZR33, with an existing insulin, Degludec, in adults with type 1 diabetes. Researchers want to see how these insulins work in the body and if the new one is safe and well-tolerated. It's an early-stage study.
Germany - ongoing, recruitingTherapeutic exploratory (Phase II)
DiaPrecise, A Phase II Open Label Study to evaluate the safety and feasibility of intralymphatic administration of Diamyd® in individuals at risk for Type 1 diabetes carrying the HLA DR3-DQ2 haplotype
This study looks at a new treatment called Diamyd for people at risk of type 1 diabetes. Researchers want to see if giving Diamyd injections into a lymph node is safe and possible. This is an early-stage study to gather important information.
Sweden - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Diamyd® to Preserve Endogenous Beta Cell Function in Adolescents and Adults with Recently Diagnosed Type 1 Diabetes, Carrying the Genetic HLA DR3-DQ2 Haplotype
This study looks at a new treatment called Diamyd for teenagers and adults recently diagnosed with Type 1 diabetes. Researchers want to see if it can help preserve the body's natural ability to make insulin. It’s a major study to check how well it works and if it's safe.
Germany · Spain · Czechia - active not recruitingPHASE2
Frexalimab in Preservation of Endogenous Insulin Secretion Compared to Placebo in Adults, Adolescents and Children on Top of Insulin Therapy (FABULINUS)
This study looks at a new drug called frexalimab for people aged 12-35 newly diagnosed with Type 1 Diabetes. It aims to see if frexalimab, taken alongside insulin, can help the body keep making its own insulin. Half the participants will get frexalimab, and half a dummy medicine.
United States · Austria · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence study of a proposed biosimilar insulin glargine U300 with Toujeo®
This study is testing a new version of insulin for people with Type 1 diabetes. It wants to see if this new insulin works in the same way as an existing insulin called Toujeo®. This is an early-stage study to check if they are similar.
Germany - recruitingPHASE2
Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus
This study is looking into a new medicine called Rezpegaldesleukin for people recently diagnosed with Type 1 Diabetes. It aims to see if the medicine can help their bodies make more insulin. Participants will receive the medicine or a dummy treatment over six months.
United States · Canada - recruitingPHASE1
A Study of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus (T1DM)
This study looks at a new medicine called LY3938577 for type 1 diabetes. We want to see how it works in the body and if it helps control blood sugar, comparing it to existing insulin treatments. Safety is also a key focus.
Germany - recruiting
Fr1da Early Diagnosis and Care of Type 1 Diabetes
The Fr1da study looks for early signs of type 1 diabetes in children aged 2-10 in Germany. It aims to find the condition sooner to prevent serious health problems and help families cope better. Screening is also offered to relatives at higher risk.
Germany - recruitingNA
Feasibility of a Tailored Online Self-compassion Intervention
This study looks at an online self-compassion program for people with type 1 or type 2 diabetes. It aims to see if the program can help reduce distress, self-criticism, and shame, and improve health by teaching new ways to cope with their condition.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
A GLP-1 receptor PET imaging add-on study within the VERA-T1D trial investigating the effects on beta cell mass (Image-VER-A-T1D)
This study is looking at how two treatments, exenatide and verapamil, might affect the cells in the pancreas that make insulin in people with type 1 diabetes. We're using a special scan to see if these cells change over 12 months.
Austria · France - recruitingPHASE2, PHASE3
A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
This study looks at whether a weekly medicine, tirzepatide, can help adults with type 1 diabetes manage their blood sugar more easily with an insulin pump, especially by reducing or removing the need to count carbs at meals.
Canada · Switzerland - active not recruitingPHASE3
The Fenofibrate And Microvascular Events in Type 1 Diabetes Eye.
This study looks into whether a daily tablet called fenofibrate can help protect the eyes of adults with Type 1 diabetes. It aims to see if this medicine can prevent or slow down eye damage, which is a common problem for people with diabetes.
Australia · Hong Kong · New Zealand