- recruitingPHASE3
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
This study looks at new and existing medicines (CagriSema and Semaglutide) to help people with obesity, sometimes with type 2 diabetes, lose weight. Researchers want to see how safe and effective these medicines are. It lasts about 83 weeks.
United States · Argentina · Australia - recruitingPHASE1
Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes II
This study looks at different low-dose aspirin treatments for people with type 2 diabetes. We want to find the best way to help aspirin work well to thin the blood and understand why it doesn't work for some people.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to test how a new long-acting insulin works in the body of patients with type 2 diabetes during exercise and prolonged fasting.
This study is looking at a new, long-acting insulin for people with type 2 diabetes. Researchers want to see how it works in the body during exercise and when you haven't eaten for a longer time. It's an early-stage study to understand the new insulin better.
Austria - active not recruiting
Predicting Dysglycemia in Individuals With Gestational Diabetes Immediately Postpartum Using Continuous Glucose Monitoring
This study looks at how a small stick-on sensor can help new mums who had diabetes during pregnancy. It aims to find out if this sensor can predict their risk of developing diabetes again, more easily than current tests.
Canada - active not recruitingPHASE3
Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
This study looks at a new medicine called cagrilintide for people with overweight or obesity and type 2 diabetes. It aims to see how well cagrilintide helps people lose weight. Participants will receive either the new medicine or a dummy medicine.
United States · Argentina · Canada - recruitingNA
Technology-Enabled Collaborative Care for Diabetes and Mental Health
This study looks at a new way to help people in the UK manage type 2 diabetes and mental health challenges together. It tries out virtual health coaching and team support to see if it improves overall health and wellbeing compared to usual care.
Canada - not yet recruitingNA
REMIssion of Type 2 Diabetes Between Intermittently Scanned Continuous Glucose Monitoring and Capillary Blood Glucose Monitoring When Added to Low-calorie Meal Replacement and Diabetes Self-management Education
This study looks at how different ways of checking blood sugar levels affect people with type 2 diabetes trying to get their condition into remission. It combines a special diet and education to see if a small sensor (continuous glucose monitor) helps more than finger-prick tests.
Canada - recruitingNA
Gut Hormones and Roux en Y Gastric Bypass
This study looks at how weight-loss surgery (gastric bypass) changes natural body chemicals called 'gut hormones'. We want to see if these changes help people with obesity and type 2 diabetes by burning more energy, eating less, losing weight, and changing how they react to food.
United Kingdom - recruitingNA
DiEt ChoIce to Promote Type 2 Diabetes REmission
This study looks at returning blood sugar to normal for people with Type 2 Diabetes through diet. It compares two diets – low-calorie or low-carb – to see which works best for putting diabetes into remission. The goal is to reduce or stop diabetes medication.
Canada - active not recruitingNA
Community Gardens and Environmental Health in Mississauga
This study in Mississauga looks at how community gardening helps people with or at risk of Type 2 Diabetes. It aims to improve a garden program to see if it can boost health, make healthy food more available, and encourage physical activity.
Canada - active not recruitingPHASE2
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
This study is looking into a new medicine called tirzepatide. It aims to see if tirzepatide can help people with kidney disease who are also overweight or living with obesity, whether or not they have type 2 diabetes.
United States · Austria · Canada - active not recruiting
Multi-morbidity Screening in People With Type 2 Diabetes and Pre Diabetes
This study checks for other health issues often linked with Type 2 diabetes and pre-diabetes, like problems with your heart, liver, or sleep. It's testing a new, more thorough health check-up to find these problems earlier.
United Kingdom - active not recruitingPHASE3
Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
This study looks at a new medicine called Retatrutide for people with Type 2 Diabetes and kidney problems. It checks if the medicine improves blood sugar control and is safe, compared to a dummy medicine, for those already on insulin.
United States · Argentina · Brazil - ongoing, recruitingTherapeutic confirmatory (Phase III)
J2A-MC-GZGV: A Phase 3, Randomized, Open-Label Study to Investigate the Efficacy and Safety of Once Daily Oral Orforglipron Compared with Dapagliflozin in Adult Participants with Type 2 Diabetes and Inadequate Glycemic Control with Metformin (ACHIEVE-2)
This study looks at a new drug, orforglipron, for people with type 2 diabetes whose blood sugar isn't well controlled with metformin. It compares orforglipron with an existing drug, dapagliflozin, to see how well they lower blood sugar and if they're safe.
Poland · Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Study to Evaluate the Efficacy and Safety of Once-weekly Insulin Icodec when Switching from Daily Basal Insulins Compared to Once-daily Insulin Glargine U100 in Adults with Type 2 Diabetes
This study is looking at a new once-a-week insulin treatment, called insulin icodec, for people with type 2 diabetes. It's comparing it to a daily insulin, Lantus, to see if the weekly option is safe and works just as well to control blood sugar.
Poland · Spain · Bulgaria - ongoing, recruitingTherapeutic exploratory (Phase II)
Safety and efficacy of once-weekly subcutaneous and once-daily oral NNC0487-0111 in participants with type 2 diabetes – a dose finding study
This study is testing a new medicine, NNC0487-0111, for people with type 2 diabetes. It's looking at different ways to take the medicine (once a week shot or once a day pill) to see how safe and effective it is at controlling blood sugar.
Romania · Spain · Poland - recruiting
Pancreas lipotoxicity in type 2 diabetes: Edinburgh Diabetes Remission Study (EDRS)
This study, the Edinburgh Diabetes Remission Study (EDRS), is looking at how fat in the pancreas affects type 2 diabetes. It wants to see if losing weight can reverse the condition. Participants will follow a special low-calorie diet to help researchers understand these changes.
United Kingdom · Scotland - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase 1 study assessing the pharmacokinetics of NEX-22A in subjects with T2D
This early-stage study is for people with type 2 diabetes. It's looking at how a new medicine, NEX-22A, moves through the body. The main goal is to understand how the body handles this new treatment.
Germany - ongoing, recruitingTherapeutic use (Phase IV)
DiEtary Sodium Intake effects on ertugliflozin-induced changes in GFR, reNal oxygenation and systemic hemodynamics: the DESIGN study, a randomized, placebo-controlled, cross-over study with ertugliflozin in people with type 2 diabetes.
This study looks at how different salt levels in your diet affect a type 2 diabetes drug called ertugliflozin (Steglatro) and your blood pressure. We're comparing recommended salt intake with a higher salt diet in people with type 2 diabetes who are overweight or obese.
Netherlands - completed
Women’s Wellness Type 2 Diabetes Programme in the UK
This study looks at a 12-week online programme for women aged 45-65 with Type 2 diabetes in the UK. It aims to see if the programme helps improve their health, wellbeing, and diabetes management through an e-Book, podcasts, and peer support.
United Kingdom · England - ongoing, recruitingTherapeutic confirmatory (Phase III)
A 40-week study comparing the efficacy, safety and patient-reported outcomes of once weekly IcoSema and once or twice daily insulin degludec/insulin aspart 100 units/mL, both treatment arms with or without oral anti-diabetic drugs, in participants with type 2 diabetes inadequately controlled with daily pre-mixed insulin. COMBINE 5
This 40-week study looks at two different insulin-based treatments for adults with type 2 diabetes that isn't well-controlled. It compares a new once-weekly injection (IcoSema) with an existing daily or twice-daily insulin (Ryzodeg) to see which is more effective and safer.
Poland - recruiting
The effect of text reminders on the uptake of type 2 diabetes screening test after gestational diabetes
This study looks at whether sending text messages helps women who've had diabetes in pregnancy (gestational diabetes) remember to get their yearly check-up for type 2 diabetes. Catching it early can help keep them healthier in the long run.
United Kingdom · England - active not recruitingPHASE4
A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
This study looks at a new treatment called tirzepatide for people with type 2 diabetes. It's compared to standard care to see how well it works and if it's safe when started early. The goal is to improve blood sugar control for those with type 2 diabetes.
United States · Argentina · Canada - recruitingNA
Low EnerGy DiEt iN Adolescents With Obesity and Type 2 Diabetes: The LEGEND Study
This study looks at how a special low-energy diet helps teenagers with obesity and type 2 diabetes. It aims to see if they can lose enough weight to reverse their diabetes and how easy it is for them to stick with the diet.
United Kingdom - recruitingPHASE2
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
This study is looking into a new medication, LY3457263, for people with Type 2 Diabetes whose blood sugar levels are still high despite taking other common diabetes medicines like semaglutide or tirzepatide. It will compare the new drug with a dummy treatment (placebo).
United States · Canada · Germany - recruiting
Nottingham Community Liver Biomarkers Cohort
This study in Nottingham looks at improving how we find liver disease early in the community. It involves people with risk factors like heavy alcohol use, obesity, or diabetes, to see if new blood and scan tests can help identify liver problems before they become serious.
United Kingdom - completed
How a low-carbohydrate diet affects blood sugar and health in people living with type 2 diabetes: results from a real-life study
This study looks at how a low-carbohydrate diet helps people with type 2 diabetes manage their blood sugar and improve their health over 6 months. It involves an online program and checks on diet, weight, and blood sugar levels.
United Kingdom · England - authorisedTherapeutic use (Phase IV)
A multicenter, register-based, randomized, controlled trial comparing dapagliflozin with metformin treatment in early stage type 2 diabetes patients by assessing mortality and macro- and microvascular complications
This study compares two common diabetes medicines, dapagliflozin and metformin, for people recently diagnosed with type 2 diabetes. We want to see how these medicines affect serious health problems like heart attacks, strokes, kidney issues, and overall health over time.
Sweden - authorisedTherapeutic use (Phase IV)
EFFectiveness of once-weekly insulin ICodec versus once-daily basal Insulin analogues in an insulin-naïve type 2 diabEtes population in real-world cliNical pracTice- The EFFICIENT pragmatic study
This study looks at different insulin treatments for people with type 2 diabetes who are just starting insulin. It compares a new once-weekly insulin called Icodec with other daily insulins people usually take. The aim is to see how well they work in real life and how easy they are to use.
Germany · Italy - recruitingNA
Pancreas Lipotoxicity in T2D: Edinburgh Diabetes Remission Study (EDRS)
This study in Edinburgh looks at how fat in the pancreas affects type 2 diabetes and if losing weight can reverse it. Participants will follow a special diet to lose weight, helping researchers understand how the body changes and improves.
United Kingdom - enrolling by invitation
Sweet Sensing in Type 2 Diabetes
This study looks at how people with type 2 diabetes and prediabetes sense sweetness. We want to understand if changes in taste and brain activity affect sugar cravings. This could help develop new ways to manage blood sugar.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4/2.4 mg and 1.0/1.0 mg once weekly versus semaglutide 2.4 mg and 1.0 mg, cagrilintide 2.4 mg and placebo in participants with type 2 diabetes inadequately controlled on metformin with or without an SGLT2 inhibitor
This study is testing a new combination medicine, CagriSema, for people with type 2 diabetes. It's looking at whether this combined medicine is better at controlling blood sugar and helping with weight loss than existing treatments, including its individual components, semaglutide and cagrilintide.
Denmark · Sweden · Slovakia - active not recruitingNA
Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure
This study looks at a new way to find hidden heart failure in people with diabetes who are at higher risk. We're testing if checking a specific blood marker helps doctors discover heart problems earlier, so people can get the right care sooner.
United Kingdom - recruiting
Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction
This study looks at why people with a type of heart failure called HFpEF, especially those with Type 2 Diabetes, get so unwell. Using special MRI scans and dyes, researchers want to see how their hearts handle calcium and energy, comparing them to healthy volunteers.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
J2A-MC-GZGW: A Phase 3, Randomized, Double-Blind Study to Investigate the Efficacy and Safety of Once Daily Oral Orforglipron Compared with Placebo in Adult Participants with Type 2 Diabetes and Inadequate Glycemic Control with Insulin Glargine, with or without Metformin and/or SGLT-2 Inhibitor (ACHIEVE-5)
This study is looking into a new daily tablet, orforglipron, for adults with type 2 diabetes. We want to see if it's better than a dummy pill at helping control blood sugar when taken with insulin glargine and other diabetes medicines.
Romania - ongoing, recruitingTherapeutic confirmatory (Phase III)
A 40-week study comparing the efficacy and safety of once weekly IcoSema and daily insulin glargine 100 units/mL in participants with type 2 diabetes inadequately controlled on oral anti diabetic drugs. COMBINE 4
This study looks at a new once-a-week insulin treatment, IcoSema, for people with type 2 diabetes whose blood sugar isn't well controlled by their current medicines. It compares IcoSema to a daily insulin, glargine, to see which is better and safer.
Greece · Italy · Poland - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Investigation of safety, tolerability and pharmacokinetics of multiple doses of NNC0113‑6856 in healthy participants, including a subset of healthy Japanese participants
This study is testing a new medicine, NNC0113-6856, in healthy people, including some of Japanese background. We want to see how safe it is, how well bodies handle it, and what happens to the medicine inside the body after taking different doses.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4 mg/2.4 mg and 1.0 mg/1.0 mg once weekly versus placebo in participants with type 2 diabetes as add on to once-daily basal insulin with or without metformin
This study is looking at a new combination medicine, CagriSema, for people with type 2 diabetes. We want to see how well it helps control blood sugar and manage weight, alongside their usual insulin and other diabetes medicines.
Slovakia - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Investigating how CagriSema, semaglutide and cagrilintide regulate insulin effects in the body of people with type 2 diabetes.
This study looks at how new medicines, CagriSema and its parts (semaglutide and cagrilintide), work in people with type 2 diabetes. Researchers want to understand how these medicines affect the body's use of insulin and sugar.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4 mg/2.4 mg and 1.0 mg/1.0 mg once weekly versus placebo in participants with type 2 diabetes inadequately controlled on diet and exercise.
This study is testing a new combination medicine for people with type 2 diabetes who haven't fully managed their blood sugar with diet and exercise. It looks at how well the medicine works to lower blood sugar and help with weight loss over 40 weeks.
Italy · Hungary · Poland - ongoing, recruitingTherapeutic confirmatory (Phase III)
PIONEER TEENS Efficacy and safety of oral semaglutide versus placebo both in combination with metformin and/or basal insulin in children and adolescents with type 2 diabetes.
This study is looking at a medicine called Rybelsus for teenagers with type 2 diabetes. It wants to see if Rybelsus, taken with other common diabetes medicines, helps control blood sugar and is safe. The study compares Rybelsus to a dummy pill to understand its effects better.
Greece · Czechia · Portugal - enrolling by invitation
PDE3B in Metabolic Regulation
This study looks at how a protein called PDE3B affects how our bodies handle sugar and fat. Researchers want to understand if changes in this protein could protect people from conditions like type 2 diabetes and heart disease, potentially leading to new treatments.
United Kingdom - enrolling by invitationNA
Free Fatty Acid Effects In Type 2 Diabetes
This study looks at how omega-3 fatty acids, found in oily fish, might help people with type 2 diabetes and heart problems. Researchers want to see if omega-3s can improve blood sugar and reduce the risk of heart disease, as they are a natural and potentially safe option.
United Kingdom - active not recruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - ongoing, recruitingTherapeutic use (Phase IV)
A Phase 4, Randomized, Open-Label, Active-Controlled Study to Investigate the Efficacy and Safety of Switching From Weekly Dulaglutide to Weekly Tirzepatide in Adults With Type 2 Diabetes
This study is looking at how well a new medicine, Tirzepatide, works for adults with type 2 diabetes when they switch from another medicine called Dulaglutide. Researchers want to see if the new medicine helps lower blood sugar and improve other health markers like weight.
Romania · Germany · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A research study comparing the effect of different dosing conditions on blood levels of semaglutide in a new tablet composition in healthy participants
This study is looking at a new tablet for type 2 diabetes. It aims to see how different amounts of the medicine, semaglutide, affect its levels in the blood of healthy male volunteers.
Germany - recruitingNA
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids
This study looks at how omega-3 from fish oil might help prevent type 2 diabetes. Researchers are exploring if lowering 'bad cholesterol' in a certain way can increase diabetes risk, and if omega-3 can help counteract this in some people.
Canada - recruitingNA
Improving Insulin Sensitivity in Patients With Type 2 Diabetes Via Repeated Cold-induced Shivering Thermogenesis
This study looks at whether getting a little cold and shivery could help people with Type 2 Diabetes manage their blood sugar and heart health better. Researchers believe regular, mild shivering might improve how the body uses insulin, offering a new way to support health alongside diet and exercise.
Canada - authorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2 Open-Label, Single Ascending Dose, First-In-Human Study to Assess Safety and Tolerability of Endoscopic Ultrasound-Guided Pancreatic Infusion of RJVA-001 in Adults With Inadequately Controlled Type 2 Diabetes on Multiple Glucose-Lowering Agents.
This study is testing a new treatment, RJVA-001, for adults with Type 2 diabetes that isn't well-controlled. It's the first time this treatment is being given to people. Doctors want to see if it's safe, what dose works best, and how it affects blood sugar.
Netherlands - active not recruitingPHASE4
Combined Active Treatment in Type 2 Diabetes with NASH
This study is looking at new ways to treat a liver condition called NASH in people with type 2 diabetes. We're testing two medicines, empagliflozin and semaglutide, to see if they can help improve liver health. This is important because there are currently no specific treatments for NASH.
Austria · Germany