- active not recruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - recruitingPHASE2
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
This study is looking into a new medication, LY3457263, for people with Type 2 Diabetes whose blood sugar levels are still high despite taking other common diabetes medicines like semaglutide or tirzepatide. It will compare the new drug with a dummy treatment (placebo).
United States · Canada · Germany - recruitingNA
GLycaemic Outcomes With Whey Protein in ageING
This study looks at whether whey protein taken before meals can help older adults (75-90) with Type 2 Diabetes manage their blood sugar levels better. Participants will try different doses of whey protein and a harmless dummy powder.
United Kingdom - ongoing, recruitingTherapeutic use (Phase IV)
A Phase 4, Randomized, Open-Label, Active-Controlled Study to Investigate the Efficacy and Safety of Switching From Weekly Dulaglutide to Weekly Tirzepatide in Adults With Type 2 Diabetes
This study is looking at how well a new medicine, Tirzepatide, works for adults with type 2 diabetes when they switch from another medicine called Dulaglutide. Researchers want to see if the new medicine helps lower blood sugar and improve other health markers like weight.
Romania · Germany · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A research study comparing the effect of different dosing conditions on blood levels of semaglutide in a new tablet composition in healthy participants
This study is looking at a new tablet for type 2 diabetes. It aims to see how different amounts of the medicine, semaglutide, affect its levels in the blood of healthy male volunteers.
Germany - recruitingNA
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids
This study looks at how omega-3 from fish oil might help prevent type 2 diabetes. Researchers are exploring if lowering 'bad cholesterol' in a certain way can increase diabetes risk, and if omega-3 can help counteract this in some people.
Canada - recruitingNA
Improving Insulin Sensitivity in Patients With Type 2 Diabetes Via Repeated Cold-induced Shivering Thermogenesis
This study looks at whether getting a little cold and shivery could help people with Type 2 Diabetes manage their blood sugar and heart health better. Researchers believe regular, mild shivering might improve how the body uses insulin, offering a new way to support health alongside diet and exercise.
Canada - authorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2 Open-Label, Single Ascending Dose, First-In-Human Study to Assess Safety and Tolerability of Endoscopic Ultrasound-Guided Pancreatic Infusion of RJVA-001 in Adults With Inadequately Controlled Type 2 Diabetes on Multiple Glucose-Lowering Agents.
This study is testing a new treatment, RJVA-001, for adults with Type 2 diabetes that isn't well-controlled. It's the first time this treatment is being given to people. Doctors want to see if it's safe, what dose works best, and how it affects blood sugar.
Netherlands - active not recruitingPHASE4
Combined Active Treatment in Type 2 Diabetes with NASH
This study is looking at new ways to treat a liver condition called NASH in people with type 2 diabetes. We're testing two medicines, empagliflozin and semaglutide, to see if they can help improve liver health. This is important because there are currently no specific treatments for NASH.
Austria · Germany - recruitingNA
Improving Kidney Care in Type 2 Diabetes: A Study of Pharmacist Prescribing Versus Usual Care
This study checks if pharmacists using special guides can help people with type 2 diabetes and early kidney damage get the right medicines. It compares this to standard care for those without a regular doctor, aiming to improve long-term health.
Canada - recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - not yet recruitingNA
Community-integrated Nutrition Education to Prevent Type 2 Diabetes in Peel
This study in Peel, Ontario, explores if healthy eating and community gardening can lower the risk of type 2 diabetes. It teaches a special diet and includes gardening to help people stay healthy and prevent this condition.
Canada - recruitingNA
Glucose Monitoring After Acute Myocardial Infarct in People With Diabetes
This study looks at how using a special glucose monitor (Dexcom ONE) might help people with type 2 diabetes manage their blood sugar after a heart attack. It aims to see if better blood sugar control improves health over six months.
United Kingdom - recruiting
Global Research Initiative for Patients Screening on MASH
This study aims to improve how doctors find serious liver conditions like MASH in people with health problems like diabetes or obesity. It brings together healthcare providers across Europe to use new care guidelines and raise awareness about these liver diseases.
Belgium · Czechia · France - recruitingNA
PROTeIn-rich Meals to Control Glucose
This study looks at how different eating patterns might help people with prediabetes or type 2 diabetes manage their blood sugar. Researchers are comparing two diets to see which is better for controlling sugar levels and body inflammation.
Germany - recruitingNA
taRgeting bEtA-Cell Function To achIeVe Remission of Type 2 diAbeTEs
This study looks at a new way to help people with newly diagnosed Type 2 diabetes. It compares a special automated insulin device with standard care to see if it can help put diabetes into remission, meaning you might not need medication.
United Kingdom - recruiting
Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass
This study looks at how a medicine called semaglutide (Ozempic/Wegovy®) affects your heart and muscles over a year. Researchers use special scans and tests to understand if it helps keep your muscles healthy, especially if you have type 2 diabetes or obesity.
Canada - not yet recruitingNA
Effects of HIIT Following PTR Programme
This study looks at whether a home-based exercise program (HIIT) can help people who have put their Type 2 diabetes into remission to stay diabetes-free for longer. It compares this special exercise with usual care after completing the NHS Path to Remission program.
United Kingdom - active not recruitingPHASE3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
This study is looking at a new medicine called orforglipron for people with obesity or who are overweight and have type 2 diabetes. It wants to see how well it helps control blood sugar compared to a dummy medicine, called a placebo.
United States · Argentina · China - enrolling by invitationNA
Effects of Dried Whole Fruits on Metabolism in Diabetes
This study looks at whether eating dried Saskatoon berries can help people with prediabetes or new type 2 diabetes manage their blood sugar and gut health, compared to eating dried apple slices.
Canada - recruitingNA
Time Restricted-EAting for Type 2 Diabetes and MEtabolic Health: the TEA TIME Trial
This study looks at how 'time-restricted eating' (eating only within certain hours) affects type 2 diabetes. Researchers want to see if it helps manage blood sugar and improves how the body uses insulin, especially for people recently diagnosed with type 2 diabetes.
Canada - recruiting
Capillary OGTT Study
This study is looking for new, easier ways to test for diabetes (Type 1 and Type 2) in children and young people. Instead of tricky hospital blood tests, we want to see if finger-prick tests at home or skin sensors can give reliable results.
United Kingdom - not yet recruitingNA
A Multi-centre Trial to Assess the Efficacy and Safety of the Omnipod 5 System in People With Type 2 Diabetes Undergoing Haemodialysis
This study looks at a new automated insulin system, Omnipod 5, for people with type 2 diabetes and advanced kidney failure on dialysis. It aims to see if it improves blood sugar control and quality of life compared to usual care.
United Kingdom - recruitingNA
Helping Couples Communicate Better: Does This Help Persons With Type 2 Diabetes Respond Better to a Step Count Prescription?
This study looks at how couples can improve communication to help people with Type 2 Diabetes walk more. Participants will use step counters, set goals, and some will get counselling to help them work together for better health.
Canada - active not recruiting
Longitudinal Assessment of Multiple Organs in Patients With Type 2 Diabetes
This study looks at how Type 2 diabetes affects important organs like your kidneys, liver, and heart. We're using special MRI scans to find out who might be at risk of complications, helping us understand and manage diabetes better for people in the UK.
United Kingdom - recruiting
Evaluation of Quality Improvement for People with Type 2 Diabetes
This study looks at how to best help GP practices in England improve care for young adults with Type 2 diabetes. It compares different levels of support to see what works best and is good value for money.
United Kingdom - completed
Exploring engagement and implementation of a digital self-management programme designed for people living with early-onset type 2 diabetes
This study looks at a new online programme (EOT2D MyDESMOND) for younger adults (18-45) with type 2 diabetes. It aims to help them manage their condition, feel better, and improve their health, specifically focusing on how well people use the programme and its availability.
United Kingdom · England - recruiting
The Sunnybrook Type 2 Diabetes Study
This study looks at how Type 2 Diabetes and prediabetes affect mood, thinking, and overall health. It examines lifestyle, genes, and brain scans to understand these links better. The goal is to improve care for people living with these conditions.
Canada - recruiting
The Sarcopenia Study
This study looks at muscle weakness, called sarcopenia, in people with heart failure. Researchers want to see if different types of heart failure affect how common sarcopenia is, comparing heart failure patients to healthy people and those with type 2 diabetes.
United Kingdom - recruitingPHASE3
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
This study looks at new and existing medicines (CagriSema and Semaglutide) to help people with obesity, sometimes with type 2 diabetes, lose weight. Researchers want to see how safe and effective these medicines are. It lasts about 83 weeks.
United States · Argentina · Australia - recruitingPHASE1
Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes II
This study looks at different low-dose aspirin treatments for people with type 2 diabetes. We want to find the best way to help aspirin work well to thin the blood and understand why it doesn't work for some people.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to test how a new long-acting insulin works in the body of patients with type 2 diabetes during exercise and prolonged fasting.
This study is looking at a new, long-acting insulin for people with type 2 diabetes. Researchers want to see how it works in the body during exercise and when you haven't eaten for a longer time. It's an early-stage study to understand the new insulin better.
Austria - active not recruiting
Predicting Dysglycemia in Individuals With Gestational Diabetes Immediately Postpartum Using Continuous Glucose Monitoring
This study looks at how a small stick-on sensor can help new mums who had diabetes during pregnancy. It aims to find out if this sensor can predict their risk of developing diabetes again, more easily than current tests.
Canada - active not recruitingPHASE3
Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
This study looks at a new medicine called cagrilintide for people with overweight or obesity and type 2 diabetes. It aims to see how well cagrilintide helps people lose weight. Participants will receive either the new medicine or a dummy medicine.
United States · Argentina · Canada - recruitingNA
Technology-Enabled Collaborative Care for Diabetes and Mental Health
This study looks at a new way to help people in the UK manage type 2 diabetes and mental health challenges together. It tries out virtual health coaching and team support to see if it improves overall health and wellbeing compared to usual care.
Canada - not yet recruitingNA
REMIssion of Type 2 Diabetes Between Intermittently Scanned Continuous Glucose Monitoring and Capillary Blood Glucose Monitoring When Added to Low-calorie Meal Replacement and Diabetes Self-management Education
This study looks at how different ways of checking blood sugar levels affect people with type 2 diabetes trying to get their condition into remission. It combines a special diet and education to see if a small sensor (continuous glucose monitor) helps more than finger-prick tests.
Canada - recruitingNA
Gut Hormones and Roux en Y Gastric Bypass
This study looks at how weight-loss surgery (gastric bypass) changes natural body chemicals called 'gut hormones'. We want to see if these changes help people with obesity and type 2 diabetes by burning more energy, eating less, losing weight, and changing how they react to food.
United Kingdom - recruitingNA
DiEt ChoIce to Promote Type 2 Diabetes REmission
This study looks at returning blood sugar to normal for people with Type 2 Diabetes through diet. It compares two diets – low-calorie or low-carb – to see which works best for putting diabetes into remission. The goal is to reduce or stop diabetes medication.
Canada - active not recruitingNA
Community Gardens and Environmental Health in Mississauga
This study in Mississauga looks at how community gardening helps people with or at risk of Type 2 Diabetes. It aims to improve a garden program to see if it can boost health, make healthy food more available, and encourage physical activity.
Canada - active not recruitingPHASE2
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
This study is looking into a new medicine called tirzepatide. It aims to see if tirzepatide can help people with kidney disease who are also overweight or living with obesity, whether or not they have type 2 diabetes.
United States · Austria · Canada - active not recruiting
Multi-morbidity Screening in People With Type 2 Diabetes and Pre Diabetes
This study checks for other health issues often linked with Type 2 diabetes and pre-diabetes, like problems with your heart, liver, or sleep. It's testing a new, more thorough health check-up to find these problems earlier.
United Kingdom - active not recruitingPHASE3
Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
This study looks at a new medicine called Retatrutide for people with Type 2 Diabetes and kidney problems. It checks if the medicine improves blood sugar control and is safe, compared to a dummy medicine, for those already on insulin.
United States · Argentina · Brazil - ongoing, recruitingTherapeutic confirmatory (Phase III)
J2A-MC-GZGV: A Phase 3, Randomized, Open-Label Study to Investigate the Efficacy and Safety of Once Daily Oral Orforglipron Compared with Dapagliflozin in Adult Participants with Type 2 Diabetes and Inadequate Glycemic Control with Metformin (ACHIEVE-2)
This study looks at a new drug, orforglipron, for people with type 2 diabetes whose blood sugar isn't well controlled with metformin. It compares orforglipron with an existing drug, dapagliflozin, to see how well they lower blood sugar and if they're safe.
Poland · Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Study to Evaluate the Efficacy and Safety of Once-weekly Insulin Icodec when Switching from Daily Basal Insulins Compared to Once-daily Insulin Glargine U100 in Adults with Type 2 Diabetes
This study is looking at a new once-a-week insulin treatment, called insulin icodec, for people with type 2 diabetes. It's comparing it to a daily insulin, Lantus, to see if the weekly option is safe and works just as well to control blood sugar.
Poland · Spain · Bulgaria - ongoing, recruitingTherapeutic exploratory (Phase II)
Safety and efficacy of once-weekly subcutaneous and once-daily oral NNC0487-0111 in participants with type 2 diabetes – a dose finding study
This study is testing a new medicine, NNC0487-0111, for people with type 2 diabetes. It's looking at different ways to take the medicine (once a week shot or once a day pill) to see how safe and effective it is at controlling blood sugar.
Romania · Spain · Poland - recruiting
Pancreas lipotoxicity in type 2 diabetes: Edinburgh Diabetes Remission Study (EDRS)
This study, the Edinburgh Diabetes Remission Study (EDRS), is looking at how fat in the pancreas affects type 2 diabetes. It wants to see if losing weight can reverse the condition. Participants will follow a special low-calorie diet to help researchers understand these changes.
United Kingdom · Scotland - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase 1 study assessing the pharmacokinetics of NEX-22A in subjects with T2D
This early-stage study is for people with type 2 diabetes. It's looking at how a new medicine, NEX-22A, moves through the body. The main goal is to understand how the body handles this new treatment.
Germany - ongoing, recruitingTherapeutic use (Phase IV)
DiEtary Sodium Intake effects on ertugliflozin-induced changes in GFR, reNal oxygenation and systemic hemodynamics: the DESIGN study, a randomized, placebo-controlled, cross-over study with ertugliflozin in people with type 2 diabetes.
This study looks at how different salt levels in your diet affect a type 2 diabetes drug called ertugliflozin (Steglatro) and your blood pressure. We're comparing recommended salt intake with a higher salt diet in people with type 2 diabetes who are overweight or obese.
Netherlands - completed
Women’s Wellness Type 2 Diabetes Programme in the UK
This study looks at a 12-week online programme for women aged 45-65 with Type 2 diabetes in the UK. It aims to see if the programme helps improve their health, wellbeing, and diabetes management through an e-Book, podcasts, and peer support.
United Kingdom · England - ongoing, recruitingTherapeutic confirmatory (Phase III)
A 40-week study comparing the efficacy, safety and patient-reported outcomes of once weekly IcoSema and once or twice daily insulin degludec/insulin aspart 100 units/mL, both treatment arms with or without oral anti-diabetic drugs, in participants with type 2 diabetes inadequately controlled with daily pre-mixed insulin. COMBINE 5
This 40-week study looks at two different insulin-based treatments for adults with type 2 diabetes that isn't well-controlled. It compares a new once-weekly injection (IcoSema) with an existing daily or twice-daily insulin (Ryzodeg) to see which is more effective and safer.
Poland