Inflammatory Bowel Diseases research hub
50 indexed studies · 14 currently recruiting
- recruiting
Nutrition and Clinical Outcomes in IBD
This study looks at how nutrition and body health affect people with Crohn's disease and ulcerative colitis. We want to find better ways to check for poor nutrition and understand how it impacts treatment, surgery, and overall well-being in IBD patients.
United Kingdom - recruiting
NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study
This study compares body markers linked to inflammation in people with Crohn's disease or ulcerative colitis (IBD) and healthy individuals. It aims to understand IBD better and find ways to predict treatment responses, ultimately leading to improved care.
United Kingdom - recruiting
PIBD-SETQuality: the Inception Cohort and Safety Registry
This study looks at how well current treatments work and their safety for children and teenagers with Inflammatory Bowel Disease (IBD). It wants to understand how individual factors might affect treatment outcomes and serious complications.
Netherlands · United Kingdom - recruitingPHASE3
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
This study is looking at a medicine called risankizumab for children and young people with ulcerative colitis (UC). It aims to see how well and safely it works, and how it moves through the body, for those aged 2 to 17 with moderate to severe UC.
United States · Belgium · Brazil - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open-Label Extension Trial of Oral RPC1063 as Therapy for Moderate to Severe Ulcerative Colitis
This study is testing a new medicine, Ozanimod, for people in the UK with moderate to severe ulcerative colitis. It's looking at how well the medicine helps control symptoms and improve the gut, as well as checking for any side effects. It's a key stage of testing before being widely available.
Belgium · Romania · Poland - authorisedHuman Pharmacology (Phase I)- Bioequivalence Study
A double blinded, balanced, randomized, two-treatment, four-period, two-sequence, single-dose, crossover fully replicate bioequivalence study comparing Mesalamine Delayed Release Tablets USP 1.2 g manufactured by Sun Pharmaceutical Industries Limited, India with Mezavant (mesalamine) Delayed and Extended-Release Tablets 1.2 g product of Takeda Canada Inc., in healthy, adult, human subjects under fasting condition.
This study compares a new mesalamine tablet from India with an existing mesalamine tablet from Canada. It checks if the new tablet works in the same way in healthy adults. Mesalamine is a medicine used to treat ulcerative colitis.
Romania - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Testing Insulin Enemas for Ulcerative Colitis: A First-Stage Clinical Trial
This study is looking at a new way to treat ulcerative colitis using insulin delivered as an enema. It's the very first time this treatment is being tested in people. The aim is to see if it's safe and how the body reacts to it.
Poland - active not recruitingPHASE3
ABTECT - Maintenance
This study looks at a new drug, ABX464, for people with ulcerative colitis. It's for those who haven't responded well to other treatments. The study checks if ABX464 can help keep symptoms under control over a long time and if it is safe to use.
United States · Argentina · Australia - recruitingPHASE3
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
This study looks at combining two medicines, mirikizumab and tirzepatide, for adults with ulcerative colitis (UC) who are also overweight or obese. The goal is to see if this combination helps UC symptoms improve and also leads to significant weight loss.
United States · Austria · Belgium - authorisedPhase III and phase IV (Integrated)
IMPACT OF ANTI-TNF, VEDOLIZUMAB AND TOFACITINIB ON AORTIC STIFFNESS, CAROTID INTIMA-MEDIA THICKNESS AND CARDIOVASCULAR RISK OF PATIENTS WITH ULCERATIVE COLITIS
This study looks at how certain medicines for ulcerative colitis might affect heart and blood vessel health. We want to see if these treatments change the thickness of neck artery walls or how stiff the main heart artery is in people with ulcerative colitis.
France - ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, double-blind, multicenter phase 3 study in patients with moderately to severely active ulcerative colitis (UC) to compare the efficacy, safety and immunogenicity of PB016 and Entyvio® for the induction and maintenance of clinical response and remission. (UCESIVE)
This study compares a new medicine (PB016) with an existing one (Entyvio®) for adults with moderate to severe ulcerative colitis. It looks at how well they work to reduce symptoms and keep people well, as well as their safety.
Czechia · Poland · Romania - recruitingNA
Colectomy Reconstruction for Ulcerative Colitis, Ileorectal Anastomosis vs Ileal Pouch-Anal Anastomosis in Ulcerative Colitis.
This study compares two common surgeries to reconnect your gut after removing most of your large bowel for Ulcerative Colitis. It aims to see which one, an ileal pouch or an ileorectal anastomosis, offers the best quality of life, satisfaction, and fewer complications for patients in the UK.
Sweden · United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A single arm, open-label study to evaluate the efficacy and safety of ABBV-668 in subjects with moderate to severe ulcerative colitis.
This study is testing a new medicine called ABBV-668 for people with moderate to severe ulcerative colitis. Doctors want to see if it helps improve the lining of the bowel after 8 weeks and if it's safe to use. It's a key step in understanding if this medicine could help patients.
Belgium · France · Poland - authorisedTherapeutic exploratory (Phase II)
T-FORE - Pilot study of a new technique of Oral Fecal Transplantation using frozen stool capsules for the maintenance treatment of pediatric Ulcerative Colitis (UC)
This study looks at a new way to treat Ulcerative Colitis in children using healthy gut bacteria from donor stool. They are testing both capsules and enemas to see which method works best to improve the gut’s natural balance over time.
France - active not recruiting
Prospective Observational Study of Effectiveness and Safety of Filgotinib in Participants With Ulcerative Colitis (UC)
This study looks at how a medicine called filgotinib works for people with ulcerative colitis in everyday life. Researchers want to see if it helps with symptoms, improves quality of life, and if it's safe for people with moderate to severe disease.
Austria · Belgium · France - authorisedHuman Pharmacology (Phase I)- Bioequivalence Study
A double blinded, balanced, randomized, two-treatment, four-period, two-sequence, single-dose, crossover fully replicate bioequivalence study comparing Mesalamine Delayed Release Tablets USP 1.2 g manufactured by Sun Pharmaceutical Industries Limited, India with Mezavant (mesalamine) Delayed and Extended-Release Tablets 1.2 g product of Takeda Canada Inc., in healthy, adult, human subjects under fed condition.
This study compares a new version of Mesalamine, a medicine for ulcerative colitis, with an existing one. We want to see if the new version works in the body in the same way as the old one, in healthy adults who have eaten.
Romania - recruitingPHASE3
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
This study looks at a medicine called Mirikizumab for children and teenagers aged 2 to 19 with Ulcerative Colitis or Crohn's Disease. It checks how well the medicine works over a long time to help manage these conditions.
United States · Austria · Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, Multicenter Phase 2 Induction Study with Long-Term Extension to Evaluate the Clinical Activity and Safety of Oral NX-13 in Participants with Moderate to Severe Ulcerative Colitis
This study is testing a new medicine called NX-13 for people in the UK with moderate to severe ulcerative colitis. Researchers want to see if it helps reduce symptoms and is safe compared to a dummy pill.
Belgium · Poland · Italy - active not recruitingPHASE3
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
This study is an extension for people in the UK with moderately to severely active ulcerative colitis who have already taken part in a specific etrasimod trial. It aims to gather more information on the long-term safety and effectiveness of etrasimod for this condition.
United States · Australia · Austria - active not recruitingPHASE3
A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)
This study is testing a new medicine, tulisokibart, for people with moderate to severe ulcerative colitis. It aims to see if the medicine can help people feel better and stay in remission, compared to a dummy medicine, both in the short and long term.
United States · Argentina · Australia - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multi-Center, Open-Label Study of the Human Anti-TNF Monoclonal Antibody Adalimumab to Evaluate Long-Term Safety and Tolerability of Repeated Administration of Adalimumab in Pediatric Subjects with Ulcerative Colitis Who Completed the Study M11-290
This study looks at the long-term safety of a treatment called Humira for children and teens with ulcerative colitis. It's for those who have already been on Humira in a previous study. We want to see how well they continue to do.
Slovakia · Poland - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Ulcerative Colitis
This study is testing a new medicine called Rosnilimab for people with moderate to severe Ulcerative Colitis. Researchers want to see if it helps reduce symptoms and improve gut health compared to a dummy treatment, and if it's safe to use.
France · Germany · Austria - recruitingPHASE2
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
This study is looking into a new treatment, RO7837195, for people with moderate to severe ulcerative colitis whose usual treatments haven't worked well. It aims to see if the new drug is safe and effective in helping manage the condition.
United States · Australia · Brazil - active not recruiting
An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice
This study looks at how a medicine called upadacitinib works for adults with moderate to severe Ulcerative Colitis in everyday life. Researchers will check its safety and how well it helps manage the condition, following about 1000 people over three years.
Argentina · Australia · Canada - active not recruitingPHASE2
Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called emvistegrast for people with moderate to severe ulcerative colitis. It aims to see if emvistegrast can help improve their symptoms compared to a dummy medicine.
United States · Australia · Austria - ongoing, recruitingTherapeutic exploratory (Phase II)
Orismilast for the treatment of moderate to severe ulcerative colitis
This study is looking into a new medicine called Orismilast for people in the UK with moderate to severe ulcerative colitis. It's a Phase II trial, meaning it's still in the earlier stages of testing. Researchers want to see if the medicine can help people feel better by reducing symptoms.
Denmark - authorisedTherapeutic exploratory (Phase II)
Multi-center, single-arm, phase II clinical trial evaluating efficacy and in-vivo homing of adoptively transferred autologous ex-vivo expanded regulatory T cells in adults with ulcerative colitis
This study is testing a new cell therapy for adults with ulcerative colitis. It involves taking your own immune cells, growing more of them in a lab, and then giving them back to you. Researchers want to see if this helps reduce symptoms within 12 weeks.
Germany - active not recruitingPHASE3
A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab
This study compares two approved medicines, risankizumab and vedolizumab, for adults with moderate to severe ulcerative colitis who haven't tried similar treatments before. It looks at how safe and effective they are. Around 530 people will take part worldwide.
United States · Austria · Bulgaria - active not recruitingPHASE3
A Study of Mirikizumab (LY3074828) in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called mirikizumab for adults with ulcerative colitis. It aims to see how well it helps reduce urgent bowel movements in people with moderate to severe disease, especially if other treatments haven't worked.
United States · Belgium · Czechia - recruitingPHASE2
A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis
This study is testing a new drug, SAR442970, for adults with moderate to severe Ulcerative Colitis. It compares different doses of the drug to a dummy pill to see if it helps reduce symptoms and is safe.
United States · Australia · China - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1b, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Safety, Engraftment, and Initial Signs of Clinical Activity of MB310 in Patients with Active, Mild to Moderate Ulcerative Colitis (COMPOSER-1)
This study is looking into a new treatment called MB310 for people with ulcerative colitis. It's an early-stage trial checking if the treatment is safe, how well it settles in the body, and if it shows any early signs of helping patients with mild to moderate symptoms.
Austria · Poland · Bulgaria - active not recruitingPHASE2
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis
This study looks at a new medicine called TAK-279 for adults with moderate to severe ulcerative colitis. It aims to see if it reduces bowel inflammation and symptoms compared to a dummy medicine, and to check for any side effects.
United States · Australia · Belgium - active not recruitingPHASE3
Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.
This study looks at a medicine called Upadacitinib for children and young people aged 2-17 with moderate to severe ulcerative colitis. It aims to see how safe and effective the medicine is, how it works in the body, and if it helps reduce symptoms.
United States · Australia · Belgium - active not recruitingNA
Implementing a Multimodal RCT Intervention to Improve the Transition of Patients With Crohn's Disease From Pediatric to Adult Care
This study looks at a new support program for young people with Crohn's or ulcerative colitis who are moving from children's to adult healthcare. It aims to make this move smoother and improve their health and well-being.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, 2-part, placebo-controlled study to evaluate the efficacy, safety, and PK of PF-07054894 in participants with mild to severe UC.
This study is testing a new medicine called PF-07054894 for people with ulcerative colitis. It will check if the medicine is safe, how well it works, and how the body uses it, compared to a dummy pill.
Germany · Poland - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Learn How Different Amounts and Forms of the Study Intervention Called PF-07899895 are Tolerated and Act in the Body of Healthy Adults
This study is looking at a new medicine called PF-07899895 to see how well healthy adults tolerate it and how it works in their bodies. This is the first time it's being given to people.
Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b Multicenter, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Moderately to Severely Active Ulcerative Colitis
This study is testing a new medicine, JNJ-77242113, for people in the UK with moderate to severe ulcerative colitis. We want to see if it helps reduce symptoms and if it's safe compared to a dummy pill.
Czechia · Spain · Poland - active not recruitingPHASE3
Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
This study is looking at a medicine called tofacitinib for children aged 2-17 with a bowel condition called ulcerative colitis. It aims to see how well it works, how safe it is, and how the body uses it, especially if other treatments haven't worked.
United States · Australia · Belgium - authorisedTherapeutic confirmatory (Phase III)
FirST lines of biologics in pAtients with ulceRaTivE colitis: a Randomised controlled trial
This study is comparing different medicines for ulcerative colitis. It aims to find out which new treatments work best to help people feel better and get their symptoms under control. We're looking at things like stopping bleeding and improving bowel habits over time.
France - authorisedTherapeutic use (Phase IV)
Switching to Mesalazine Monotherapy vs Continuing Thiopurines in Older Patients with Ulcerative Colitis in Sustained Remission: A Multicenter Randomized Controlled Trial (IDEA).
This study compares two ways to manage ulcerative colitis in older patients who are feeling well: continuing their usual medicine (thiopurines) or switching to a different one (mesalazine). It checks which approach is better at keeping the condition stable.
Spain - recruiting
Pregnancy and Inflammatory Bowel Disease
This study looks at how inflammatory bowel disease (IBD) affects pregnancy and how pregnancy affects IBD. We're studying women with Crohn's disease or ulcerative colitis who have been pregnant, aiming to understand symptoms during pregnancy and after birth.
France - recruitingPHASE3
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
This study is looking at a new medicine called filgotinib for children and teenagers aged 8 to 18 with moderate to severe ulcerative colitis. It aims to see how well it works, if it's safe, and how the body handles it, compared to what we already know about its use in adults.
Belgium · Croatia · France - recruitingPHASE4
Impact of Anti-TNF, Vedolizumab and Tofacitinib on Aortic Stiffness, Carotid Intima-media Thickness and Cardiovascular Risk of Patients With Ulcerative Colitis
This study looks at how certain medicines for ulcerative colitis affect your heart and blood vessels. Researchers want to see if drugs like anti-TNF, vedolizumab, and tofacitinib change things like blood vessel stiffness or thickness over time.
France - active not recruitingPHASE2, PHASE3
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called guselkumab for people with ulcerative colitis that isn't well-controlled. We want to see if it helps reduce symptoms and if it's safe to use for those with moderate to severe forms of the condition.
United States · Argentina · Australia - active not recruitingPHASE2
A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)
This study is looking into a new treatment called Rosnilimab for people in the UK with moderate to severe ulcerative colitis. It aims to see how safe and effective it is compared to a dummy treatment.
United States · Austria · Bulgaria - active not recruitingPHASE3
Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis
This study looks at the long-term safety of a medicine called filgotinib for adults with ulcerative colitis. It's for people who have already been in another filgotinib study. The main goal is to see if taking filgotinib over a longer time is safe.
United States · Argentina · Australia - recruiting
Robotic Inflammatory Bowel Disease Development, Learning and Efficacy Study
This study looks at using robotic surgery for inflammatory bowel disease (IBD) like Crohn's disease and ulcerative colitis. Researchers want to see if robots can help surgeons operate more effectively and how this new method compares to traditional keyhole surgery for IBD.
United Kingdom - active not recruitingPHASE2
A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis
This study looks at a new medicine called lutikizumab for adults with moderate to severe ulcerative colitis. It aims to see if it's safe and how well it works compared to a common treatment called adalimumab.
United States · Australia · Austria - recruitingPHASE4
A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)
This study looks at combining two medicines, vedolizumab and tofacitinib, for adults with moderate to severe ulcerative colitis. We want to see if this combination helps more than vedolizumab alone, especially for people who haven't responded well to other treatments.
United States · Canada - ongoing, recruitingTherapeutic use (Phase IV)
(A)nalysis of immunological (VA)riables in ex vivo (T)ofacitinib-treated human biopsies from (A)ctive ulcerative colitis patients to predict clinical (R)esponse (the AVATAR study).
This study looks at how a medicine called Xeljanz (tofacitinib) affects cells from people with ulcerative colitis. Researchers want to understand if these early changes can help predict which patients will get better with this treatment.
Italy