PIK3CA-Related Overgrowth Spectrum (PROS) research hub
3 indexed studies · 3 currently recruiting
- recruitingPHASE2
A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)
This study is testing a new medicine called RLY-2608 for adults and children with certain conditions where parts of their body have grown too much or developed unusually due to a specific genetic change. It aims to see if the medicine is safe and if it can help improve these conditions.
United States · Australia · Belgium - enrolling by invitation
Investigation of Lipedema, Lymphedema and Vascular Malformations by Multispectral Optoacoustic Tomography (MSOT)
This study uses a new scanning method called MSOT to look closely at fat, fluid, and blood vessels in conditions like lipedema and lymphedema. It aims to understand these conditions better and improve diagnosis and treatment.
Germany - recruitingPHASE3
Efficacy and Safety of Sirolimus in Vascular Anomalies That Are Refractory to Standard Care
This study is looking into a medication called Sirolimus for people with vascular malformations (unusual growths of blood vessels) that haven't responded to other treatments. It aims to see how well it works and if it's safe for children and adults.
Belgium · France · Germany