- RecruitingPHASE2, PHASE3
Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features
This study looks at new treatments for endometrial cancer based on specific cancer features. It aims to find better ways to treat patients after surgery, potentially leading to personalised care for different types of endometrial cancer.
For: Endometrial CancerCanada · France · Netherlands - Recruiting
Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)
This study looks at heart and blood vessel conditions, like heart attacks or high blood pressure, in hospital patients and healthy people. Researchers will collect information and samples to better understand these conditions, improve diagnosis, and predict how they might progress.
For: Cardiovascular Diseases · Cardiovascular Risk FactorUnited Kingdom - Active not recruitingNA
Randomized, Open-label, Two-arms, Phase III Comparative Study Assessing the Role of Involved Mediastinal Radiotherapy After Rituximab Containing Chemotherapy Regimens to Patients With Newly Diagnosed Primary Mediastinal Large B-Cell Lymphoma
This study looks at treating a type of lymphoma in the chest. We're comparing standard radiation therapy with careful monitoring for patients whose cancer seems gone after chemotherapy, using special scans to check. It aims to see if some patients can avoid unnecessary radiation.
For: Primary Mediastinal B-cell LymphomaUnited States · Argentina · Canada - Recruiting
What is the Perceived Role of Risk in DOC Healthcare.
This study looks at how decisions are made for people with severe brain injuries who are in a 'disorder of consciousness' (DOC). Researchers will observe healthcare teams and families to understand the role of risk in these important choices.
For: Disorders of ConsciousnessUnited Kingdom - Recruiting
Vulvar Disease in Nigeria Observational Study
This study in Nigeria is looking into common vulvar (outer female genital area) problems. Researchers want to understand how many women have these conditions, how much they and healthcare workers know about them, and what these conditions are truly like in different communities.
For: Vulvar Diseases · Vulvar Atrophy · DermatosesUnited Kingdom - RecruitingPHASE3
A Randomized Phase III Trial of Stereotactic Ablative Radiotherapy for Patients With Up to 10 Oligometastases and a Synchronous Primary Tumor.
This study looks at a special type of strong radiation, called SABR, for people with a few small cancer spots that have spread, along with a main tumor. It compares SABR plus usual care to just usual care to see if it helps.
For: Metastatic TumorCanada · Switzerland - Recruiting
MPN Childhood Registry
This study is gathering information about very rare blood conditions called MPNs in children and teenagers. It aims to understand these conditions better in young people, as most research focuses on adults. By collecting data, doctors hope to improve diagnosis and treatment for children with MPNs.
For: Childhood Myeloproliferative NeoplasmsGermany - RecruitingPHASE2
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
This study looks at new, gentler treatments for early womb cancer. We want to see if these new approaches, which involve less intensive treatment, work as well as the usual care for patients with specific types of early-stage womb cancer.
For: Endometrial CancerUnited States · Australia · Canada - Active not recruitingPHASE3
PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer
This study compares standard radiotherapy for womb cancer with a newer approach using detailed tumour information. It helps doctors decide if patients need radiotherapy, and if so, what kind, to reduce the risk of the cancer coming back, without giving unnecessary treatment.
For: Endometrial Cancer Stage I · Endometrial Cancer Stage IIAustria · Belgium · Czechia - Recruiting
Cardio-Renal Registry
This study is looking at patients with kidney disease heart problems. It aims to understand why heart issues are common in people with kidney conditions and how best to treat them. We hope to improve care for these patients.
For: End Stage Renal Disease · Cardio-Renal Syndrome · Myocardial InfarctionUnited Kingdom - RecruitingPHASE3
Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and Over
This study looks at the best chemotherapy treatments for people aged 70 and over with a certain type of bowel cancer (Stage III colon cancer). It compares different treatments or no treatment to see what helps people live longer and stay cancer-free.
For: Colonic AdenocarcinomaFrance - Active not recruitingPHASE3
Galinpepimut-S Versus Investigator's Choice of Best Available Therapy for Maintenance in AML CR2/CRp2
This study looks at a new drug, galinpepimut-S, for people with a type of blood cancer called Acute Myeloid Leukaemia (AML) who are in remission. It compares the new drug to standard treatments to see if it helps people live longer.
For: Acute Myeloid LeukemiaUnited States · France · Germany - Recruiting
The Head and Neck Registry of the European Reference Network on Rare Adult Solid Cancers
This project is building a secure online registry for rare head and neck cancers. It aims to collect information from across Europe to better understand these conditions, how they are treated, and what affects treatment success, helping improve care for patients.
For: Head and Neck Cancer · Nasopharynx Cancer · Nasal Cavity and Paranasal Sinus CancerCzechia · Germany · Italy - RecruitingPHASE2
Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer
This study looks at new ways to treat advanced breast cancer that has stopped responding to standard treatments. By checking your blood or tumour for specific signs, doctors hope to find the best treatment for you, exploring several new drugs and combinations.
For: Breast CancerCanada - Recruiting
Fetal Ebstein Anomaly and Tricuspid Valve Dysplasia Registry
This study looks at a rare heart condition in unborn babies called Ebstein Anomaly. We want to understand more about how it affects babies before and after birth, to help doctors make better decisions and improve care. It involves observing babies with the condition.
For: Ebstein Anomaly · Tricuspid Valve DysplasiaCanada - Active not recruitingPHASE3
Stereotactic Ablative Radiotherapy for Comprehensive Treatment of 4-10 Oligometastatic Tumors
This study looks at a special type of radiation (SABR) for people with cancer that has spread a little (4-10 spots). It compares SABR to usual treatments to see if it helps people live longer, keeps cancer away, and improves their quality of life.
For: Metastatic TumorsAustralia · Canada · Netherlands