- Active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
For: Glioblastoma · Melanoma Stage IV · Breast CancerUnited States · United Kingdom - RecruitingPHASE3
Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment
This study compares a new, shorter radiation treatment for prostate cancer with the usual treatment. It checks if the new method, using high-dose radiation in fewer sessions, works as well as the standard approach which combines external radiation with tiny radioactive seeds placed inside the prostate.
For: Prostate CancerUnited States · Canada - RecruitingPHASE2
Neoadjuvant, SBRT With Intratumoural Pembrolizumab Followed by Neoadjuvant Chemotherapy in Breast Cancer
This study is looking at a new way to treat certain breast cancers before surgery. It combines a special type of radiation with a medicine called pembrolizumab, followed by standard chemotherapy, to see if it can make treatments more effective.
For: Breast Cancer · Breast Cancer Stage II · Breast Cancer Stage IIICanada - Active not recruitingPHASE2
Radiochemotherapy +/- Durvalumab for Locally-advanced Anal Carcinoma. a Multicenter, Randomized, Phase II Trial of the German Anal Cancer Study Group
This study is testing if adding a drug called durvalumab to standard treatment (chemotherapy and radiation) works better for advanced anal cancer. Researchers want to see if this new combination improves how well people respond to treatment.
For: Anal Cancer · Anal Carcinoma · Anal Cancer Stage IIIAustria · Germany · Switzerland - Active not recruitingPHASE2
De-Escalation Radiotherapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma
This study looks at treating a type of throat cancer linked to HPV. We want to see if we can reduce radiation treatment for some patients to lessen side effects, without making the cancer more likely to come back.
For: Oropharyngeal CancerCanada - RecruitingPHASE2, PHASE3
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
This study is testing different treatments for a type of brain cancer called glioblastoma. It's for people who have been recently diagnosed or whose cancer has come back. The aim is to find better ways to treat this cancer.
For: GlioblastomaUnited States · Australia · Canada - RecruitingNA
The Radiation ProtEction for Dose RedUction in the Cardiac CathEter Lab Study: The REDUCE Trial
This study looks at a new device called RAMPART to protect heart doctors and nurses from radiation during X-ray procedures. They compare it to standard protection to see if RAMPART can make their work safer and more comfortable by reducing radiation exposure.
For: Radiation Exposure · Radiation Exposure to Operator · Radiation InjuriesUnited Kingdom - Active not recruitingPHASE2
Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC
This study looks at new ways to treat a type of throat cancer called oropharyngeal squamous cell carcinoma, linked to HPV. It compares standard radiotherapy and chemotherapy with newer immunotherapy drugs, durvalumab and tremelimumab, to see if they can work better at stopping the cancer from coming back.
For: Oropharyngeal Squamous Cell CarcinomaBelgium · Canada · Italy - RecruitingPHASE3
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer
This study looks at whether some women with early-stage breast cancer can skip a type of radiation treatment called regional radiotherapy. Researchers want to see if not having this radiation is just as good at stopping the cancer from coming back, helping women avoid unnecessary side effects.
For: Breast CancerUnited States · Canada