Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC

To be considered for this study, you would need to have been diagnosed with a specific type of throat cancer (oropharyngeal squamous cell carcinoma) that is linked to the Human Papillomavirus (HPV). This cancer should be locally advanced but not have spread to other parts of your body. Doctors will check this using scans and biopsies.

You also need to be generally well enough to take part, meaning you can mostly look after yourself. The study is open to both men and women, and you must be at least 18 years old. If you're a woman who could get pregnant, or a man whose partner could get pregnant, you'll need to agree to use effective contraception during the study. You'll also need to provide some tissue samples (from your tumour), blood, saliva, and a throat swab for further tests. You should also be able to understand and complete questionnaires about your quality of life.

If you join this study, your journey will begin with a thorough check-up, including scans and assessments, to make sure you're suitable. Once you're officially in the study, you'll be assigned to one of the treatment groups – either the standard treatment (radiation plus cisplatin) or one of the groups receiving radiation plus durvalumab, potentially followed by more durvalumab. All initial treatments, including radiation and chemotherapy/immunotherapy, will be given for a specific period.

After the initial treatment, depending on your assigned group, you might continue to receive durvalumab (and previously, tremelimumab) as an 'additional' treatment to help prevent the cancer from returning. This would involve regular visits to the hospital for these infusions. You'll also have regular check-ups, scans, and blood tests throughout the treatment period and for a while afterwards, to monitor your health and how well the treatment is working. You will also be asked to fill out questionnaires about how you are feeling and your quality of life. The exact number of visits, tests, and total length of your involvement will depend on your specific treatment path, but follow-up is generally long-term to track your progress.