Optimizing Reperfusion to Improve Outcomes and Neurologic Function

To join this study, people need to be between 18 and 90 years old. They must have recently had an ischaemic stroke, where a blood vessel in the brain was blocked. Doctors will check scans to make sure there's brain tissue that could still be saved and that the stroke isn't too severe in other ways.

There are also some reasons why someone might not be able to join. For example, if scans show a very large area of brain damage, or if there's bleeding in the brain, or signs of a chronic blockage. People with certain serious medical conditions, like uncontrolled high blood pressure, problems with blood clotting, or a high risk of bleeding, might also not be able to take part. Recent major surgery or trauma could also exclude someone.

If you decide to take part, you would be randomly assigned to receive either the study medicine, JX10, or a dummy medicine called a placebo. You would have regular check-ups with the study doctors and nurses, which would include physical exams, blood tests, and brain scans. They would closely monitor your health and recovery after your stroke. The study involves several visits to the hospital or clinic, where different assessments would be done to track your progress and any side effects. The total length of your participation would be explained by the study team, including how often you would need to come in for follow-up appointments.