Not yet recruitingNAINTERVENTIONAL

T2 Biomarkers Predictive Value in Occupational Asthma After Cessation of Exposure.

This research is trying to understand why some people with asthma caused by their job get better after they stop being exposed to what triggered it, while others don't. Currently, we can't tell who will recover. This study focuses on special natural signals in the body called T2 biomarkers. Researchers think these signals, which are already used to help manage other types of asthma, might be able to predict if someone's work-related asthma will go away after they leave the harmful environment. They will follow up with people previously diagnosed with work-related asthma in Strasbourg to see if their T2 biomarker levels at the start can show who will get better and who won't.

At a glance

Status

Not yet recruiting

Phase

Sponsor

University Hospital, Strasbourg, France

Enrolment target

Start

01 Jun 2025

Estimated completion

01 Jun 2026

Asthma Occupational Asthma Occupational Diseases

What is this study about?

If you have asthma that's caused by your job, it's called occupational asthma. Doctors usually advise you to stop being around whatever is causing it. While this often helps, unfortunately, not everyone fully recovers. In fact, only about 3 out of 10 people get completely better, and right now, there's no way for doctors to know who will improve and who won't. This can be really frustrating for patients and doctors alike.

This study hopes to change that. Researchers are looking at some natural signals in your body called T2 biomarkers. In other types of asthma, these T2 biomarkers have been very useful. They can help doctors understand what kind of asthma a person has and even predict future flare-ups. The idea is that these same T2 biomarkers might also be able to predict whether someone with work-related asthma will recover after they are no longer exposed to the cause.

To find this out, the study team at the University Hospital of Strasbourg is going to follow up with people who have already been diagnosed with work-related asthma. They will do a special breathing test to see if their asthma has gone away, and then compare their T2 biomarker levels from the beginning of their treatment to see if these levels can predict who got better and who didn't. This could lead to a better way to predict recovery for people with occupational asthma.

Key takeaways

Understanding why some people with work-related asthma recover and others don't.
Investigating if natural body signals (T2 biomarkers) can predict recovery.
This could help doctors predict who will get better after stopping exposure.
The study involves follow-up visits and breathing tests.
No new medications are being tested in this study.

Who may be eligible?

To take part in this study, you need to be at least 18 years old. You must have been formally diagnosed with asthma caused by your job, and you should no longer be exposed (or are much less exposed) to the thing that triggered your asthma. It's also important that you can understand what the study involves and agree to take part freely.

If you are a woman who could become pregnant, you would need to be using effective birth control. You also need to have social security coverage in place.

There are some reasons why you wouldn't be able to join. For example, if you can't properly understand the information given to you, or if you are pregnant or breastfeeding. Also, if you are under special legal protection (like guardianship), you wouldn't be eligible.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you been diagnosed with asthma caused by your job?
Have you stopped or significantly reduced your exposure to what caused it?
Can you understand the study information and agree to take part?
If you could get pregnant, are you using effective birth control?
Are you not currently pregnant or breastfeeding?

Answer every question to see your result.

What does participation involve?

If you choose to take part in this study, the researchers will check your T2 biomarker levels. They will also carry out a non-specific bronchial hyperresponsiveness test. This is a breathing test that helps assess if your asthma symptoms have improved or gone away. The total duration of your participation would involve these measurements and assessments as part of a follow-up visit. The study is focused on observation and data collection, rather than trying new medications.

Potential risks and benefits

Taking part in this study could potentially help us understand more about occupational asthma, which might benefit future patients. There are no new medications or treatments involved, so you won't be exposed to those risks. The main risk might be the time involved for the follow-up visit and tests. You are free to withdraw from the study at any time without giving a reason, and it won't affect your medical care.

Locations (1)

University Hospital of Strasbourg
Verified postcode
Strasbourg, France

Common questions

What are T2 biomarkers?

T2 biomarkers are natural signals in your body that can tell doctors about the type of inflammation (swelling) in your lungs related to asthma.

What is occupational asthma?

Occupational asthma is asthma that has been caused or made worse by something you breathe in at your workplace.

Will I receive new treatment in this study?

No, this study doesn't involve new treatments. It's about observing and collecting information to understand your condition better.

What does 'remission' mean for asthma?

In this study, remission means that your asthma symptoms have significantly improved or gone away after stopping exposure to what caused it.

Will I be compensated for taking part?

The information provided does not specify any compensation for participation. You should ask the study team for details.

How to find out more

Naji KHAYATH, Doctor

naji.khayath@chru-strasbourg.fr 3 69 55 09 02 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.