Severe asthma exacerbations in partial and uncontrolled preschool research hub
50 indexed studies · 26 currently recruiting
- ongoing, recruitingTherapeutic confirmatory (Phase III)
A prospective multicenter placebo-controlled trial to study the efficacy and safety of Tiotropium in preventing severe asthma exacerbations in partial and uncontrolled preschool asthma.
This study is looking at a new inhaler medicine called Tiotropium for young children with asthma that isn't fully controlled. We want to see if it can help prevent severe asthma attacks, like those needing hospital trips or strong steroid medicines, and if it's safe to use.
Germany - active not recruiting
Registry of Asthma Patients Initiating DUPIXENT®
This study looks at how a medicine called DUPIXENT® is used by real people with asthma. It helps us understand who uses it and how well it works over time in everyday life, not just in strict research settings.
United States · Canada · Denmark - active not recruitingPHASE2
A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
This study is looking at a new medicine called rocatinlimab for people aged 18-75 with moderate to severe asthma. It wants to see if the medicine can reduce asthma attacks. Participants will receive either rocatinlimab or a dummy medicine called a placebo.
United States · Argentina · Australia - recruiting
A Trial Evaluating Novel Technologies for the Diagnosis of Asthma The LUNG-TECH Trial
This study, called LUNG-TECH, is looking for new and better ways to diagnose asthma. It aims to test new technologies to see if they can accurately identify asthma in different groups of people, from healthy volunteers to those already suspected of having asthma.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomised, Double-blind, Parallel Group, Placebo Controlled, 4-Week, Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults with Asthma - Artemisia study
This study, called Artemisia, is looking at a new medicine called AZD4604 to see if it can help people with asthma. Researchers want to understand how the medicine affects inflammation in the airways over four weeks, compared to a dummy medicine.
Germany · Denmark · Spain - not yet recruiting
London Asthma Diagnostics Study
This study looks at new ways to diagnose asthma in adults. Researchers want to see if adding a breathing test called oscillometry helps doctors diagnose asthma more accurately, alongside standard tests. It could lead to better and quicker diagnosis for you.
United Kingdom - active not recruitingPHASE1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Immunogenicity of APG777 in Adults With Asthma
This study is looking into a new medication called APG777 for adults with mild to moderate asthma. It's a first step to see if it's safe and how the body handles it, compared to a dummy drug (placebo).
United States · United Kingdom - recruitingNA
Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)
This study looks at how a self-guided online tool called SELF-BREATHE helps adults with long-term breathlessness. It aims to see if using this website improves their breathing and quality of life, and if it could be used more widely in the NHS.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase Ib, Multicentre, Randomised, Single-blind, Parallel-group, Placebo-controlled, Study to Characterise the Pharmacokinetics and Pharmacodynamics of AZD4604 Administered via the Turbuhaler® Device in Adults with Mild Asthma
This study is testing a new asthma medicine, AZD4604, given through an inhaler. It's for adults with mild asthma to see how the medicine works in the body and what effects it has, compared to a dummy treatment.
Germany - recruitingPHASE3
Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
This study is testing a new medicine, dupilumab, for children aged 2-5 who have asthma or wheezing that’s hard to control. It aims to see how well it works and if it's safe over time.
United States · Argentina · Brazil - recruiting
Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
This study looks at how lung diseases like asthma and COPD affect the body. Researchers want to understand these conditions better by studying samples from healthy people and those with lung problems to find better ways to help patients.
United Kingdom - not yet recruiting
Development of the Drug and Alcohol Respiratory Health Test
This study is creating a simple test to check lung health in adults who use certain substances. Many people with substance use disorder have breathing problems that often go unnoticed. This new test aims to find these issues early so people can get the right help.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of AZD8630, Administered Once Daily via Inhalation, for 2 Weeks, in Adults with Asthma on Medium-to-high Dose Inhaled Corticosteroids and Long-acting Beta-agonists
This study is looking at a new inhaler medicine, AZD8630, for asthma. It wants to see if the medicine is safe, how it moves through the body, and what effects it has over two weeks. It's for adults whose asthma is already treated with common inhalers.
Germany - active not recruitingPHASE4
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
This study is looking at whether a medicine called dupilumab can help adults with moderate to severe asthma keep their lungs working better over time. It compares dupilumab to standard asthma care to see if it can prevent lung function from getting worse. It's a long-term study.
United States · Belgium · Brazil - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I study to evaluate an investigational medicinal product for the treatment of asthma, in healthy adult participants.
This study is testing a new medicine for asthma for the first time in people. It involves healthy adult volunteers and aims to check if the medicine is safe and how it works in the body. This is an early step in developing new treatments for asthma.
Belgium - recruitingPHASE2
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Glycopyrronium (Bromide) in Children (6 to Less Than 12 Years) With Asthma
This study is looking at a new asthma medicine, glycopyrronium, for children aged 6 to 11. Researchers want to see how well different doses work, how safe they are, and if they can help children breathe easier. This information will help develop a new combination asthma treatment.
Bulgaria · Colombia · Guatemala - enrolling by invitationPHASE2
Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma
This study is looking at the long-term safety and effectiveness of a new medicine called Lunsekimig for adults with asthma. It's for people who have already taken part in a previous study with this medicine and want to continue their treatment.
United States · Argentina · Brazil - recruiting
A Comparison of Diagnostic Testing Modalities in the Assessment of Asthma
This study looks at different ways to diagnose asthma, comparing current guidelines with new tests like Impulse Oscillometry (IOS). We want to find the best and easiest ways to accurately identify asthma in adults, potentially improving how we manage the condition.
United Kingdom - recruitingPHASE2
Therapeutic Equivalence of CHF5993 pMDI 100/6/12.5 µg HFA-152a in Subjects With Mild to Moderate Asthma
This study looks at a new, climate-friendly asthma inhaler. We want to check if it works just as well and is as safe as current inhalers for people with mild to moderate asthma. It's about finding better ways to manage asthma while caring for our planet.
Argentina · Bosnia and Herzegovina · Bulgaria - active not recruitingPHASE1
A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma
This study is testing a new medicine, AMG 691, for safety in healthy people and those with mild-to-moderate asthma. Researchers want to see how the body reacts to single and multiple doses and check for side effects.
United States · Australia · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Evaluation of the CHF 5993 concentration in blood, after inhalation with two different devices, (NEXThaler® versus pMDI), with and without Aerochamber spacer device, in healthy volunteers.
This study is looking at how a common asthma medicine gets into the blood when breathed in using different inhalers and a spacer device. It's for healthy adult volunteers and aims to compare two types of inhalers, with and without a spacer, to see which way works best.
Belgium - active not recruiting
Wessex Asthma Cohort of Difficult Asthma
This study looks at people with severe asthma treated at Southampton Hospital. It aims to understand why some individuals still struggle with their asthma and how best to help them, using information gathered from regular hospital visits.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
A double-dummy, double-blind, randomized, active controlled, two-way cross-over study with 12-week treatment duration per period, to evaluate the efficacy and safety of QVM149 (indacaterol acetate / glycopyrronium bromide / mometasone furoate) compared to salmeterol xinafoate/fluticasone propionate in children from 12 years to less than 18 years of age with asthma.
This study is looking at a new asthma inhaler (QVM149) for teenagers aged 12 to 18. Researchers want to see if it works better and is safer than current inhalers to help manage asthma symptoms and improve breathing.
Poland · France · Slovakia - recruiting
The Extended Salford Lung Study ("Ex-SLS") Data Access Project
This study wants to look at the full health history of people who took part in a past asthma study called the Salford Lung Study (SLS). It aims to learn more about how asthma develops and how treatments work over many years, by reviewing their health records.
United Kingdom - recruitingPHASE1
A Study to Compare the Relative Potency of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152a to HFA-134a in Mild Asthmatics Aged 18 to 65 Inclusive
This study is looking at two different versions of salbutamol (a common asthma inhaler) delivered through a puffer. We want to see how well they work to prevent asthma symptoms in people with mild asthma, comparing a newer propellant (HFA-152a) with an older one (HFA-134a).
United Kingdom - active not recruitingPHASE1
A Study to Investigate GB-0895 in Adults With Mild to Moderate Asthma or COPD
This study is looking into a new medication called GB-0895 for people with mild to moderate asthma or COPD. Researchers want to see if it's safe, how the body handles it, and if it works. It's an early-stage study to gather basic information.
United States · Germany · United Kingdom - recruitingPHASE2
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
This study is looking into a new medicine, PF-07275315, for people with moderate to severe asthma who struggle with breathing. We want to see if it's safe and helps improve their daily life.
United States · Argentina · Belgium - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - active not recruiting
Stem Cell Strategies for the Treatment of Chronic Asthma
This lab study is looking into new ways to treat asthma. Researchers are testing how special cells, called 'stem cells,' might help repair damaged airways and calm inflammation using samples from people with mild, severe, or no asthma.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Comparison of the study drug CHF 1535 formulated with two different propellants to learn about drug levels in blood and safety after inhalation, with and without the use of the AeroChamber Plus® spacer, in healthy volunteers.
This study is testing a new asthma medicine. It will check how different ways of taking the medicine affect its levels in the blood and if it's safe. Healthy adults will take part, using an inhaler, sometimes with a spacer device.
Belgium - recruitingPHASE3
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
This study looks at a new asthma medicine, Depemokimab, to see how it affects people's lungs. It focuses on those with a specific type of asthma where their airways get inflamed and swollen, causing breathing problems.
United States · Belgium · Canada - active not recruitingPHASE2
Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma
This study is looking into a new medication called Lunsekimig for adults with asthma that is hard to control. It compares Lunsekimig to a dummy treatment (placebo) to see if it helps manage asthma better and if it's safe.
United States · Argentina · Belgium - recruitingPHASE3
A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma
This study looks at a new medicine called Tezepelumab for children aged 5-11 with severe asthma. It compares the medicine to a dummy treatment (placebo) to see if it helps reduce asthma attacks and is safe for children.
United States · Argentina · Brazil - ongoing, recruitingTherapeutic use (Phase IV)
Symptoms control and adhErenCe assessment during treatment with mepolizUmab new pREfilled devices. SECURE
This study looks at how well people with asthma use their medication (Mepolizumab) and how much it helps control their symptoms over six months. It compares different ways of giving the medication, looking at patient diaries and pharmacy records.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
RANDOMISED, CROSSOVER BIOEQUIVALENCE CLINICAL TRIAL OF MONTELUKAST 10 MG CAPSULES VS MONTELUKAST 10 MG FILM-COATED TABLETS, AFTER A SINGLE ORAL DOSE ADMINISTRATION TO HEALTHY VOLUNTEERS UNDER FASTING CONDITIONS.
This study is comparing two ways of taking the asthma medicine montelukast: a capsule and a film-coated tablet. We want to see if the body uses them in the same way when taken by healthy people who haven't eaten, to make sure they work equally well.
Spain - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 study to evaluate the efficacy and safety of RPT193 in adults with moderate-to-severe T2-high asthma who are partially controlled on inhaled corticosteroid and long-acting beta 2 agonist therapy
This study is testing a new medicine, RPT193, for adults with moderate to severe asthma that's not fully controlled by their usual inhalers. It aims to see how well RPT193 works and if it's safe, helping researchers understand if it could be a future treatment option.
Czechia · Bulgaria · Poland - ongoing, recruitingTherapeutic exploratory (Phase II)
A 52-week, randomised, double blind, multicentre, 2-arm parallel group trial assessing the efficacy and safety of CHF6001 (total daily dose 3200 μg) Dry Powder Inhaler (DPI) add-on to maintenance medium or high dose inhaled corticosteroid in combination with long-acting ß2-agonists in subjects with uncontrolled asthma
This study looks at a new inhaler, CHF6001, for people with asthma that isn't fully controlled. Researchers want to see if adding this new inhaler to their usual medication helps reduce asthma attacks over 52 weeks and is safe.
Italy · Spain · Czechia - recruiting
Exploring the Lived Experience of Young Adults With Severe Asthma
This study explores the daily experiences of young adults (16-25) with severe or uncontrolled asthma in Manchester and Liverpool. We aim to understand their challenges and needs to improve future care and support for this group, which is often overlooked.
United Kingdom - recruitingPHASE2
Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease
This study uses special MRI scans with safe gases to look at lungs in people with cystic fibrosis and asthma, and healthy volunteers. The aim is to see how well these new scanning methods work and what they can tell us about lung health.
Canada - recruiting
Diaphragmatic Function as a Biomarker
This study looks at how your breathing muscles, especially your diaphragm, work if you have lung conditions like asthma or COPD. We want to understand if problems with these muscles are linked to feeling breathless and what that might mean for your health.
Germany - authorisedTherapeutic use (Phase IV)
Therapheutic optimization of omalizumab in allergic severe asthma patients by dose and frequency of administration adjustment
This study is looking at whether adults with severe allergic asthma can take a lower dose of their Xolair (omalizumab) medication and still control their asthma well. Researchers want to see if a 50% dose reduction keeps asthma stable, improves quality of life, and maintains lung function.
Spain - recruitingPHASE2
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
This study is testing a new medicine, tozorakimab, for adults with asthma that isn't well-controlled. It's looking at how well different doses work and if they are safe, compared to a dummy treatment.
United States · Argentina · Brazil - recruitingPHASE3
A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma
This study is testing a new inhaler for people aged 12 and over with asthma. It compares a combination medicine to individual medicines and a dummy inhaler to see how well it works and if it's safe.
United States · Argentina · Bulgaria - recruitingPHASE4
Therapeutic Relevance of Abnormal Airway Morphology in Asthma
This study looks at why some people with asthma don't get relief from their inhalers. We're using special scans to see if narrow or blocked airways stop medicine from reaching where it needs to go. We'll compare how well inhaled versus oral medicines work for these patients.
Canada - recruitingNA
Improving Quality of Life for Teenagers With Asthma
This study looks at a new way to help teenagers with asthma feel more confident managing their condition. It compares a special asthma consultation with a regular one to see if the new approach improves their quality of life. It aims to help teens control their asthma better.
United Kingdom - recruiting
Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting
This study looks at how your body handles prednisolone, a common anti-inflammatory medicine, especially at higher doses. We're trying to understand if prednisolone levels in your blood are consistent and if they change over time, which could help tailor treatment for conditions like asthma or thyroid eye disease.
United Kingdom - recruiting
Pediatric Arm of DZL All Age Asthma Cohort
This study is gathering information on children with asthma. Researchers want to understand why some children keep having asthma symptoms while others grow out of it. The goal is to find better, more personal treatments for asthma in the future.
Germany - active not recruitingPHASE3
Evaluation of Triple Therapy Using Magnetic Resonance Imaging in Asthma
This study looks at a new asthma inhaler with three medicines for people whose asthma isn't well controlled. It uses special scans to see how well air gets into the lungs and aims to improve breathing and lung health.
Canada - recruitingNot Applicable
Investigation of a digital inhaler monitor and smartphone app providing real-time information on inhaler use
This study looks at a 'smart' inhaler system to help people with asthma. It checks if using a digital monitor and app can improve asthma control and if it's helpful for patients and doctors. It's like a practice run for a bigger study.
United Kingdom · England - recruiting
Biobanking for Biomarkers In Respiratory Disease, Allergic Diseases and/or Mast Cell Disorders
This study is building a collection of samples and information from people with allergies, asthma, or mast cell conditions. This 'biobank' will help scientists better understand these conditions and find new ways to diagnose and treat them in the future.
France