Long-Term Follow-Up of AvenCell Sponsored CAR-T Cell Clinical Trials
This study is checking on people who have previously received AvenCell's special CAR-T cell treatments for certain cancers, including B-cell lymphoma, chronic lymphocytic leukemia, other blood cancers, and prostate cancer. The main goal is to understand the long-term safety and how well these treatments continue to work over a longer period of time. Researchers want to see if there are any health issues that show up later on, such as new cancers, nerve problems, or immune system issues, and to generally keep track of participants' health. This helps them learn more about these new types of cancer therapies and how they affect people's health in the years after treatment. It's about gathering important information to make future treatments even better.
At a glance
What is this study about?
This study is all about patients who have taken part in previous clinical trials conducted by a company called AvenCell. These patients received a type of treatment known as CAR-T cell therapy for specific cancers like lymphoma, leukemia, other blood cancers, and prostate cancer. CAR-T cell therapy is a very advanced treatment where a patient's own immune cells are specially trained to fight cancer.
The main purpose of this follow-up study is to see how these treatments affect people in the long run. Even after a treatment has finished, it's really important for doctors and researchers to understand if there are any lingering effects, good or bad, years down the line. They want to make sure the treatments are not only effective but also safe over a long period.
So, this study will carefully look at the long-term health of participants, checking for any health problems that might appear later, such as new cancers, problems with the nervous system, or conditions where the immune system attacks the body. They will also look at how patients recover from serious infections and will gather information on pregnancies and babies if those occurred. All this information helps us understand the full picture of CAR-T cell therapies, making them safer and more effective for future patients. It helps doctors learn more about how the body reacts to these powerful new treatments.
Key takeaways
- This study tracks the long-term health of people who received AvenCell's CAR-T cell therapies.
- It aims to understand safety and how well these cancer treatments work over many years.
- The study includes patients with certain blood cancers and prostate cancer.
- No new treatments or medicines are given as part of this follow-up.
- Participation helps improve future cancer care for others.
- Your health information helps researchers learn about rare or delayed side effects.
Who may be eligible?
To be part of this study, you must have previously received one of AvenCell's special CAR-T cell treatments as part of an earlier AvenCell clinical trial. This study is specifically for long-term follow-up of those treatments.
You also need to be able to understand the study and agree to take part by signing a consent form. This shows you understand what the study involves and agree to its terms.
However, you can't join if you're unable to provide this written consent or if the study doctor doesn't think you'll be able to follow the study's requirements. These requirements are in place to make sure the study gathers accurate and useful information.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Have you previously received an AvenCell CAR-T cell therapy in an AvenCell clinical trial?
- Are you able to provide written agreement to join the study after understanding it?
- Are you willing and able to follow the study's instructions and appointments?
- Did your previous AvenCell treatment target B-cell lymphoma, leukemia, another blood cancer, or prostate cancer?
What does participation involve?
If you join this study, it means you'll be giving doctors and researchers updates on your health over a long period. This isn't about getting a new treatment; it's about checking on your health after your previous CAR-T cell therapy. The study will mainly involve regular health check-ups and answering questions about your health. Doctors will be looking for any health problems that might show up after your treatment, like new cancers or issues with your immune system.
They may ask you to visit a clinic for these check-ups, or some information might be collected over the phone. The specific number of visits or calls and how long you'll be followed will be explained fully if you are eligible and interested. There won't be any new medication given as part of *this* study, as it's purely for long-term health monitoring. You will be followed for an unspecified duration to gather all necessary long-term data.
Potential risks and benefits
Locations (5)
- Charité Universitätsmedizin BerlinVerified postcodeBerlin, Germany
- Technische Universitaet Dresden - Universitaetsklinikum Carl Gustav CarusVerified postcodeDresden, Germany
- Universitätsklinikum MarburgVerified postcodeMarburg, Germany
- Klinikum der Universität (LMU) MuenchenVerified postcodeMunich, Germany
- Universitatsklinikum UlmVerified postcodeUlm, Germany
Common questions
What kind of treatments are being looked at?
This study is following up on special treatments called CAR-T cell therapies developed by AvenCell, previously given for certain cancers.
What types of cancer are involved?
The study includes people treated for B-cell lymphoma, chronic lymphocytic leukemia, other blood cancers, and prostate cancer.
Will I receive new medicine in this study?
No, this study is about checking your health after previous treatments, not giving new ones.
What happens if I want to stop participating?
You can leave the study at any time without having to give a reason, and it won't affect your medical care.
Why is this long-term follow-up important?
It helps doctors understand the long-term effects and safety of these advanced cancer treatments, which can improve care for everyone.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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