- recruiting
LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study
This study looks at how new cancer treatments affect daily life for people with long-term cancer. It aims to understand how to best support them while they are on these treatments, often for many months or years.
Canada - recruitingNA
Assessing a Digital Exercise Intervention for Health Outcomes and Engagement in Regular Exercise
This study looks at a digital exercise programme for men with prostate cancer on hormone therapy. It aims to see if online group exercise can help them stick to exercise and improve health, reducing side effects from their treatment.
United Kingdom - active not recruitingPHASE3
Androgen-Deprivation Therapy and Radiation Therapy in Treating Patients With Prostate Cancer
This study looks at different ways to treat prostate cancer using a combination of hormone therapy and radiation. Doctors want to see if a certain type of radiation, along with hormone therapy, helps patients live longer and better.
United States · Canada · Hong Kong - recruitingPHASE2
Postop Hypofractionated Radiation Therapy and LHRH in Patients With Prostate Cancer
This study looks at a new way to treat prostate cancer after surgery using a shorter course of radiotherapy and hormone therapy. It aims to see how safe and effective this combined treatment is for men whose cancer had a higher chance of coming back after their operation.
Canada - active not recruitingNA
Focal Salvage HDR Brachytherapy for the Treatment of Prostate Cancer
This study looks at a new way to treat prostate cancer that has come back only in the prostate after previous treatment. It uses targeted radiation seeds to treat just the affected area, hoping to reduce side effects compared to treating the whole prostate.
Canada - not yet recruitingPHASE2
Study of Radiation Therapy in Combination With Darolutamide + Degarelix in Intermediate Risk Prostate Cancer
This study looks at treating intermediate-risk prostate cancer with radiation and a new hormone therapy. It aims to see if adding the hormone therapy package (darolutamide + degarelix) works better than radiation alone, especially for certain men.
Canada - active not recruitingNA
A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants With Localized Prostate Cancer
This study compares two treatments for prostate cancer: standard surgery (radical prostatectomy) and a new, less invasive treatment called the TULSA procedure. It aims to see if TULSA is as good at treating cancer but causes fewer side effects, like problems with bladder control or sexual function.
United States · Canada · Finland - active not recruitingNA
Evaluation of Late Toxicity Following Intensity-Modulated Radiotherapy and Two Image-Guided Strategies With Corresponding Treatment Margins.
This study looks at a new way to give radiation therapy for prostate cancer using tiny implants. It aims to see if this method reduces side effects compared to standard treatment, by guiding the radiation more accurately.
France - recruitingPHASE3
Study Evaluating the Efficacy and Safety of Darolutamide and Stereotactic Dose Escalated Radiotherapy in Patients With Localized Prostate Cancer and High-risk Features of Relapse
This study is testing new ways to treat prostate cancer that is considered high-risk. It combines a new drug called darolutamide and a special type of radiation therapy with standard treatments to see if they can better stop the cancer from spreading.
France · Martinique - recruitingNA
A Pan-Canadian, Investigator Initiated Clinical Trial With Focal IRE Directed to Intermediate-Risk Prostate Cancer
This study looks at a new treatment called NanoKnife for men with mid-risk prostate cancer. It uses electricity to kill cancer cells, aiming to reduce side effects compared to standard treatments. Researchers want to know if it's safe and effective.
Canada - active not recruitingPHASE3
Comparison of HDR vs. LDR Brachytherapy as Monotherapy for Intermediate Risk Prostate Cancer
This study compares two types of radiation treatment for prostate cancer: LDR and HDR brachytherapy. It aims to see which method causes fewer bladder and bowel problems and helps men recover faster, especially when used alone without other radiation.
Canada - active not recruitingPHASE1, PHASE2
Intermittent Androgen Deprivation Therapy With or Without Stereotactic Body Radiotherapy for Molecularly Identified Hormone Sensitive Oligometastatic Prostate Cancer
This study looks at a new way to treat prostate cancer that has spread a little. We're testing if focused radiation (SBRT) added to hormone therapy works better than hormone therapy alone for men whose cancer shows up on a special scan but not on regular scans.
Canada - active not recruitingPHASE2
Hypofractionated Whole-Pelvis Radiotherapy (WPRT) vs Conventionally-Fractionated WPRT in Prostate Cancer
This study compares two ways of giving radiotherapy for prostate cancer: a standard approach (25 treatments) and a shorter approach (5 treatments with higher doses). It wants to see if the shorter treatment is just as good, especially for quality of life, and could become the new standard of care.
Canada - authorisedTherapeutic exploratory (Phase II)
Molecular theranostics for metastatic prostate cancer: PSMA, FAPI, or both?
This study looks at new scans to find prostate cancer that has spread. It compares two types of scans to see which is best at spotting these cancer cells in the body.
Finland - active not recruitingPHASE2
Multi-modality Imaging (PCa) Using Sodium MRI and PSMA PET in Men Pre-prostatectomy
This study is looking at better ways to find and understand prostate cancer before surgery. It uses special scans called Sodium MRI, PSMA PET, and Multiparametric MRI to find cancer more accurately and predict how aggressive it is.
Canada - authorisedHuman Pharmacology (Phase I)- Other
A trial in healthy participants to find out how long JNJ-101556143 stays in and acts on the body when administered as different formulations and under different food conditions
This study is looking at how a new medicine, JNJ-101556143, works in healthy men. Researchers want to understand how long it stays in the body, how different ways of taking it (like pills or liquids) affect it, and if food makes a difference.
Belgium - active not recruitingPHASE3
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
This study looks at whether taking aspirin daily after cancer treatment can stop cancer coming back and help people live longer. It focuses on common cancers like breast, bowel, and prostate cancer.
Ireland · United Kingdom - enrolling by invitationPHASE2, PHASE3
Prostate Cancer Patient Management With 18F-DCFPyL PET/CT
This study looks at a new type of scan called 18F-DCFPyL PET/CT for prostate cancer. It checks if this scan helps doctors make better decisions about treatment plans for men with prostate cancer, both when they are first diagnosed or if their cancer comes back.
Canada - active not recruitingPHASE3
Phase 3, Multicenter, Randomized Study, Evaluating the Efficacy and Tolerability of Focused HIFU (High Intensity Focused Ultrasound) Therapy Compared to Active Surveillance in Patients With Significant Low Risk Prostate Cancer
This study is looking at a new way to treat early-stage prostate cancer called HIFU. It compares this focused ultrasound treatment to simply watching the cancer closely. We want to see if HIFU can destroy the cancer without the severe side effects of traditional surgery, offering a kinder treatment option.
France - recruitingNA
HDR Focal: Feasibility Study
This study looks at a new way to treat prostate cancer called focal HDR brachytherapy. It aims to target only the cancer, potentially reducing side effects compared to treating the whole prostate. We want to see if this treatment is safe and effective.
Canada - recruitingNA
Micro-UltraSound In Cancer - Active Surveillance
This study compares two scanning methods, micro-ultrasound and MRI, for monitoring men with low-risk prostate cancer. Its main aim is to see which scan is better at finding any changes in the cancer during active surveillance.
United States · Canada · Italy - not yet recruitingPHASE2
Adaptive Radiotherapy for Safe Hypofractionation
This study compares a new, more flexible way of giving radiotherapy called 'adaptive radiotherapy' with the standard treatment for certain cancers. It aims to see if this new method, which uses fewer, stronger doses, is just as safe and effective.
Canada - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - recruitingPHASE3
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
This study is testing a new medicine, ifinatamab deruxtecan (I-DXd), for men with advanced prostate cancer that has spread and isn't responding to hormone therapy. We want to see if I-DXd helps men live longer and keeps their cancer from growing compared to standard chemotherapy.
United States · Argentina · Australia - recruitingPHASE1, PHASE2
A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs
This study is looking at a new medicine called AZD9750 for men with prostate cancer that has spread. We want to find out if it's safe, how well it works alone, and how it works when given with another cancer drug.
United States · Australia · Canada - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - active not recruitingPHASE1, PHASE2
Phase I/II Study of [225Ac]Ac-PSMA-R2 in PSMA-positive Prostate Cancer, With/Without Prior 177Lu-PSMA RLT
This study looked at a new drug, 225Ac-PSMA-R2, for men with advanced prostate cancer. Researchers wanted to see if it was safe and if it helped fight the cancer. The study has finished enrolling patients.
United States · Australia · Canada - recruiting
The Predictive Value of Coexisting TMPRSS2-ERG Gene Fusion and PTEN Deletion in Prostate Cancer Patients with Biochemical Failure Status Post Salvage or Radical Radiation Therapy
This study looks at how certain changes in genes (called TMPRSS2-ERG and PTEN) in prostate cancer might predict how well men respond to hormone treatment after their cancer has returned following earlier treatment. It aims to understand if these gene changes can tell us who might benefit most.
Canada - recruitingPHASE2
Focal Brachytherapy in Patients With Selected "Low-risk" Prostate Cancer - a Phase-II-trial
This study is testing a new way to treat early prostate cancer using targeted radiotherapy. It's for men with low-risk cancer in a small area of their prostate to see if this treatment is safe and works well without needing to treat the whole prostate.
Germany - recruiting
PROCARE - PROstate Cancer Real World Evidence Registry
This study is gathering information on men with prostate cancer that has come back or spread. It looks at how their condition progresses and how treatments work in real life. It aims to help us understand the best ways to manage different stages of prostate cancer.
Germany - recruiting
PROMISE PET Registry on PSMA-PET and Outcome in Prostate Cancer
This study looks at how a special scan called PSMA-PET helps doctors understand prostate cancer. It aims to see if this scan can better predict how prostate cancer might develop in patients at different stages, compared to other usual tests.
Germany - recruitingNA
Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer
This study looks at a new, more precise way to treat prostate cancer with radiation. It aims to reduce common side effects like needing to pee often, by carefully adjusting treatment daily and protecting the tube that carries urine from the body.
United States · Germany · Spain - recruiting
Determination of Prostate-specific Antigen in Capillary Blood (PSA-Cap)
This study compares a new way to test for prostate-specific antigen (PSA) from a finger-prick blood sample, alongside the usual arm blood test. This could make PSA testing easier and more convenient for detecting prostate cancer, by seeing if finger-prick results are just as reliable.
Germany - active not recruitingNA
Comparison of Intermittent Androgen Deprivation Therapy With or Without Irradiation Recovery in Prostate Cancer Patients
This study looks at treating prostate cancer that has spread a little (oligometastasis) to the pelvic lymph nodes. It compares hormone therapy alone with hormone therapy plus radiotherapy, to see if adding radiotherapy can help men stay cancer-free for longer.
France - active not recruitingPHASE3
PSMA PET/CT Guided Intensification of Therapy in Patients at Risk of Advanced Prostate Cancer
This study looks at whether a new type of scan, called a PSMA PET/CT, can help doctors find prostate cancer more accurately. By using this scan, doctors might be able to improve treatments like radiotherapy or surgery for men with prostate cancer that is at higher risk of spreading.
Canada - recruitingPHASE3
A Trial of 5 Fraction Prostate SBRT Versus 5 Fraction Prostate and Pelvic Nodal SBRT
This study compares two ways of giving radiotherapy in 5 sessions for prostate cancer. Half of men receive radiotherapy to the prostate, while the other half get it for both the prostate and surrounding lymph nodes, to see which is safer and more effective.
Ireland · New Zealand · United Kingdom - not yet recruitingPHASE2
Clinical Trial to Observe the Effects of Tamoxifen on Testosterone Recovery in Medically Castrated Prostate Cancer Patients
This study looks at whether a medicine called Tamoxifen can help men with prostate cancer recover their natural testosterone levels faster after they’ve had prostate cancer treatment that lowers hormones. It aims to improve their quality of life.
Canada - recruitingPHASE4
Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy
This study looks into a drug called Semaglutide for men with prostate cancer who are already on hormone treatment. It wants to see if the drug is safe and if it helps with weight and other health factors like blood pressure and blood sugar. It's for men aged 18 and over.
Canada - active not recruiting
A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described
This study looks at how a medicine called darolutamide (Nubeqa) works in real life for men with prostate cancer that hasn't spread and has stopped responding to other treatments. Doctors have already decided these men will receive darolutamide.
United States · Argentina · Austria - recruiting
A clinical trial to find out if using the findings from PSMA PET scans to escalate treatment can improve cancer control in patients with high-risk prostate cancer
This study looks at new scans (PSMA PET-CT) for men with high-risk prostate cancer. We want to see if using these scans to guide treatment can help control the cancer better than standard scans. It could improve future care for prostate cancer patients.
United Kingdom - completedPhase I
A study of Pasritamig (JNJ-78278343) in combination with JNJ-86974680 for treatment of prostate cancer
This study is testing two new drugs, Pasritamig and JNJ-86974680, together for men with advanced prostate cancer. Researchers want to find the safest dose and see if it helps fight the cancer. It's a very early-stage trial.
United Kingdom · England · United States of America - recruitingPHASE3
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
This study is looking at a new drug, Saruparib, for men with high-risk prostate cancer and a faulty BRCA gene. It aims to see if adding Saruparib to standard treatments can help prevent the cancer from spreading.
United States · Argentina · Australia - active not recruitingPHASE3
Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
This study is for men with a certain type of advanced prostate cancer (mCSPC) that has spread and has specific gene changes. It compares a new drug called talazoparib, given with standard treatment enzalutamide, against enzalutamide alone, to see if it's safe and effective.
United States · Argentina · Australia - active not recruiting
Using Breath, Cell Free DNA and Image Analysis to PRedIct Normal TissUe and Tumour Response During Prostate Cancer SBRT
This study aims to make prostate radiotherapy treatment more personal. We're looking at breath, DNA, and scans to predict how well your body and the cancer respond to treatment. The goal is to improve cure rates and reduce side effects during a 5-day radiotherapy course.
United Kingdom - active not recruitingNA
Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer
This study looks at how well a product called SpaceOAR Vue helps men with prostate cancer. It aims to reduce gut problems when they have a type of radiation treatment called SBRT, by putting a special gel between the prostate and bowel.
United States · Australia · France - active not recruitingPHASE3
Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate
This study looks at a new drug called darolutamide, along with standard treatments like radiotherapy and hormone therapy, for men with prostate cancer that's at a very high risk of coming back. The aim is to see if this combination can better stop the cancer from spreading and improve their long-term health.
United States · Australia · Canada - active not recruitingPHASE3
Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)
This study looks at a new combination of medicines, enzalutamide and leuprolide, for men with prostate cancer that hasn't spread but is considered high-risk. The goal is to see how safe and effective this combination is in slowing down the cancer.
United States · Australia · Austria - recruiting
Selecting Hypoxic Tumours for Treatment Modification
This study aims to find better ways to treat bladder and prostate cancers that are hard to cure with standard radiotherapy. We are testing a new method to identify these 'hard-to-treat' tumours so doctors can choose the best treatment for each patient.
United Kingdom - ongoing, recruitingTherapeutic use (Phase IV)
Determining the clinical relevance of the interaction between enzalutamide and the opioid morphine and the DOAC edoxaban to improve rational pharmacological care of patients with prostate cancer
This study looks at how a prostate cancer drug, enzalutamide, might affect other medicines like morphine (for pain) and edoxaban (a blood thinner). The aim is to make sure patients get the best and safest care when taking these drugs together.
Netherlands - authorisedTherapeutic exploratory (Phase II)
Progression under Olaparib: a randomized phaSE II trIal with docetaxel or carboplatin-docetaxel DOublet in mCRPC patieNts
This study is looking at a new way to treat prostate cancer that has spread. It compares two different drug combinations to see which is better at stopping the cancer from growing for at least four months.
Italy