- recruiting
A multi-centre, non-interventional study of relugolix in patients with advanced hormone-sensitive prostate cancer
This study looks at how a prostate cancer medicine called relugolix works in real life. It's for men whose doctor has already decided relugolix is the right treatment. Researchers will gather information from routine doctor visits to understand its effects, without changing participants' care.
United Kingdom · England · France - recruitingPHASE1, PHASE2
ACTinium in Castrate-RESistant Prostate Cancer After LUTEtium
This study is testing a new radioactive drug called Actinium (225Ac) rhPSMA-10.1 for men with advanced prostate cancer that has spread. It aims to find a safe dose and see how well it works, especially for those who've already had a similar treatment.
United Kingdom - active not recruitingPHASE2
Nivolumab and Ipilimumab Treatment in Prostate Cancer With an Immunogenic Signature
This study is testing different doses of two drugs, nivolumab and ipilimumab, for men with advanced prostate cancer that has stopped responding to standard treatments. It focuses on patients whose cancer has certain genetic ‘signatures’ that might make them more likely to respond to this type of treatment.
United Kingdom - active not recruitingPHASE2
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
This study is testing a new drug, PF-07220060, for people with advanced cancers like breast, prostate, and lung cancer. Researchers want to see if it's safe and how it works, both by itself and with other cancer medicines.
United States · Argentina · China - recruitingNA
The Man Van Project
The Man Van project offers mobile health checks at workplaces and communities for men, especially those from ethnic minority groups, to find health problems like prostate cancer early. The goal is to make healthcare easier to access and improve men's health outcomes.
United Kingdom - recruitingNA
Focal Therapy for Prostate Cancer Using HIFU
This study is looking at an advanced treatment called 'focal therapy' using HIFU for prostate cancer. It aims to see how well it controls cancer while reducing side effects like erection problems and bladder issues, which are common with other treatments.
United Kingdom - active not recruiting
Exploiting Risk-Based Risk Stratification in Early Prostate Cancer to Discriminate Progressors From Non-Progressors
This study looks at men with early prostate cancer to understand why some cancers grow and others don't. Researchers will use MRI scans and samples over time to find differences between progressive and non-progressive cancers, aiming to improve future treatment decisions.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
Prospective Study of Added Value of Florastamin (18F) PET/CT in Localisation of Clinically Significant Prostate Cancer in Patients with PI- Report of Multi-Parametric MRI, Elevated Serum PSA Levels and/or PSA Density and with Clinical Suspicion of Prostate Cancer
This study is looking at a new imaging test, called Prostavue, for men who might have prostate cancer. It wants to see how well Prostavue can find prostate cancer and help doctors decide on the best treatment plan.
Austria - recruitingNot Specified
Aiming to understand how the primary tumour in the prostate, and the treatment of this, can affect secondary tumours at other sites
This study looks at how treating the main prostate cancer tumour can affect any cancer that has spread. We want to find better ways to treat advanced prostate cancer and stop it from becoming resistant to medicines.
United Kingdom · England - recruitingNA
Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions
This study looks at a new, very short course of radiotherapy for prostate cancer, given in just two treatments. We want to see if different ways of targeting the dose can reduce side effects while still controlling the cancer.
Canada · United Kingdom - active not recruitingPHASE1, PHASE2
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.
United States · Australia · Canada - active not recruitingPHASE2
Additional Treatments to the Local Tumour for Metastatic Prostate Cancer: Assessment of Novel Treatment Algorithms
This study looks at new ways to treat prostate cancer that has spread. It compares adding treatments directly to the prostate and other affected areas with standard care, to see if it improves outcomes for men who have recently been diagnosed.
United Kingdom - authorisedPhase I and Phase II (Integrated)- First administration to humans
99mTechnetium and Cyanine-5 (HybriD) Prostate Specific Membrane Antigen (PSMA) Tracer-gUided Surgery in ProstAte Cancer - a FeasibiLity Study (DUAL study)
This study looks at a new way to help surgeons find prostate cancer more easily during operations. It uses a special tracer that lights up cancer cells. This could help surgeons remove all the cancer and improve treatment for men with prostate cancer.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
An open label, balanced, randomized, two-treatment, two-period, two-sequence, single dose crossover bioequivalence study comparing Enzalutamide film coated tablets 80 mg, Manufactured for Sun Pharmaceutical Industries Limited, India with XTANDI (Enzalutamide) 80 mg film coated tablets, Made by: Patheon Inc., 2100 Syntex Court, Mississauga, Ontario – Canada, Imported and registered by: Astellas Farma Brasil Importação e Distribuição de Medicamentos Ltda., São Paulo-SP, Brazil, in healthy adult, male subjects under fasting condition.
This study is comparing two versions of a prostate cancer medicine called enzalutamide in healthy men. It wants to see if a new generic version works the same way in the body as the original one, to make sure it's just as effective.
Romania - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom - active not recruitingNA
SPCG17: Prostate Cancer Active Surveillance Trigger Trial
This study looks at how best to manage prostate cancer through 'active surveillance'. This means closely monitoring the cancer instead of immediate treatment. We want to find out if clear guidelines for monitoring can reduce unnecessary treatments while still keeping you safe.
Denmark · Finland · Norway - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - recruitingPHASE2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
This study looks at a new injection, ASP5541, for advanced prostate cancer that has spread. It compares ASP5541 to a standard tablet treatment, abiraterone acetate, to see how safe and effective it is.
United States · China · France - active not recruitingNA
Prostate Testing for Cancer and Treatment
This study, called 'Prostate Testing for Cancer and Treatment' (ProtecT), is looking at how different treatments for prostate cancer compare. It's for men aged 50-69 with early prostate cancer. Researchers want to see if surgery, radiation, or simply watching the cancer works best in the long run.
United Kingdom - recruitingNA
Imperial Prostate 7 - Prostate Assessment Using Comparative Interventions - Fast Mri and Image-fusion for Cancer
This study looks at new ways to find prostate cancer using MRI scans and biopsies. Researchers want to see if a shorter, simpler MRI is as good as the usual one, and if guiding biopsies with a computer is better than relying on a doctor’s eye.
United Kingdom - recruiting
The i4i PRODICT® Study: Evaluation of the i4i PRODICT® Test in Different Ethnic Groups (The i4i PRODICT® Study).
This study looks at a new saliva test, called i4i PRODICT®, to predict prostate cancer risk in men aged 40-55 from different ethnic backgrounds. It aims to see how well men accept and use this test.
United Kingdom - recruiting
Precision Medicine in the Prostate Cancer Care Pathway
This study looks at a special genetic test for prostate cancer. It helps men understand their personal risk and how this information can guide decisions about screening and treatment. The aim is to use genetic insights for more tailored prostate cancer care.
United Kingdom - active not recruitingPHASE1
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer
This study is testing a new cancer medicine, botensilimab, sometimes with another drug, balstilimab. It's for people with advanced cancers that haven't responded to other treatments. Doctors want to see if it's safe, how it works, and find the best dose.
United States · United Kingdom - recruitingPHASE3
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
This study looks at a new drug, mevrometostat, combined with enzalutamide for men with prostate cancer that has spread. It compares this combination to enzalutamide alone, to see if it works better for those not yet treated with specific hormone therapies.
United States · Argentina · Australia - recruitingPHASE2
TherApeutics in Early ProState Cancer (TAPS02)
This study is looking at a new way to treat early prostate cancer. It tests a drug called apalutamide (Erleada) in men who are already under careful watch for their cancer. We want to see if this short-term treatment can help.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
PSMA PET For intermediate- or high-risk prostate cancer prior to RadioTherapY: A prospective interventional randomized clinical trial (P4RTY)
This study looks at a special scan called PSMA PET for men with prostate cancer before radiotherapy. It aims to see if this scan helps manage their cancer better and improves their health over time compared to standard care.
Germany - recruiting
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
This study, called IRONMAN, is collecting information from men with advanced prostate cancer across many countries, including the UK. It aims to understand treatments, how they vary, and what helps men live longer and have a better quality of life.
United States · Australia · Barbados - recruiting
In Vivo Dosimetry for Brachytherapy Study
This study looks at using tiny devices to check radiation doses during brachytherapy for prostate or gynaecological cancer. The devices ensure patients receive the correct, planned amount of radiation inside their bodies, helping to make treatment safer and more effective.
United Kingdom - active not recruitingPHASE1
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
This early-stage study is testing a new drug, MOMA-313, for advanced solid tumours, including prostate, breast, and pancreatic cancers. It aims to find a safe dose and see how it works, either alone or with another drug called Olaparib, in patients whose tumours have a specific genetic weakness.
United States · Spain · United Kingdom - authorisedPhase I and Phase II (Integrated)- Other
Clinical Application of the Androgen Receptor Inhibitor Darolutamide to Upregulate the Prostate-Specific Membrane Antigen (PSMA) Protein Expression in Patients with Hormone Sensitive Prostate Cancer. - The DARO-flare Trial -
This study, called DARO-flare, explores if a drug for advanced prostate cancer, NUBEQA, can help doctors see the cancer more clearly on special scans. This might help find and treat the cancer more effectively in men with early-stage prostate cancer.
Netherlands - enrolling by invitation
Prophylactic Prostatectomy for Prostate Cancer (PPPC)
This study is gathering opinions about a possible operation called a prophylactic prostatectomy. This operation might reduce prostate cancer risk in men with high genetic risk. We want to understand if men would consider this surgery and what their concerns would be.
United Kingdom - active not recruitingNA
Evaluating the Effects of Frozen Section Technology on Oncological and Functional Outcomes at Radical Prostatectomy.
This study looks at a new surgical approach for prostate cancer called NeuroSAFE. It aims to see if this method can make surgery safer, more effective, and improve quality of life for men compared to standard robotic surgery, especially regarding issues like urine control and sexual function.
United Kingdom - active not recruitingPHASE3
Phase III Radium 223 mCRPC-PEACE III
This study is looking at whether using two treatments, Ra223 and enzalutamide, together works better than enzalutamide alone for men with prostate cancer that has spread to their bones. Doctors want to see if this combination can stop the cancer from growing for longer.
Belgium · Brazil · Canada - not yet recruitingNA
Comparing pOrtable MRI and TRUS-Fusion Prostate Biopsy to Assess aCcuracy of Prostate Cancer Detection
This study compares a new, portable MRI-guided biopsy for prostate cancer with the current standard method. It aims to see if the portable MRI is just as good, or better, at finding cancer and if it can make the process simpler for patients.
United Kingdom - recruitingNA
The Remote Study: Investigating the Effects or Online Exercise on Quality of Life in Men With Prostate Cancer
This study looks at how online exercise coaching can improve the well-being of men with prostate cancer who are on long-term hormone therapy. It's an 8-week programme using virtual sessions to see if this approach is helpful and can be offered more widely.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to assess how radium-223 moves through the patients with prostate cancer receiving radium-223 dichloride treatment.
This study looks at how a medicine called radium-223 moves through the bodies of men with prostate cancer who are receiving this treatment. It helps doctors understand how the drug works and is processed by the body.
Austria · Italy · Lithuania - active not recruitingPHASE2
Artificial Intelligence Supporting CAncer Patients Across Europe - the ASCAPE Project
This study uses AI to improve life quality for breast and prostate cancer patients across Europe. It aims to create personalised predictions about challenges patients might face and suggest ways doctors can help, using smart technology and data.
Greece · Spain · Sweden - recruitingPHASE1, PHASE2
Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer
This study looks at a new drug combination, Gedatolisib and Darolutamide, for men with prostate cancer that has spread and is no longer responding to standard hormone therapy. It helps work out the best dose and how well it works.
United States · France · Spain - recruitingPHASE1, PHASE2
A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer
This study is looking at a new treatment called AZD6621 for men with prostate cancer that has spread. It aims to find out how safe the treatment is, how well it works, and how it moves through the body.
United States · Belgium · Canada - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - recruitingNA
A Study to Evaluate the Performance of Confocal Microscopy to Detect Positive Margins During Radical Prostatectomy
This study tests a new method, LaserSAFE, to find cancer at the edge of the prostate during surgery. This helps surgeons decide if they can save important nerves, especially for men usually not offered this option. It aims to improve surgical decisions and help men recover better.
United Kingdom - active not recruitingNA
Prostate Imaging Using MRI +/- Contrast Enhancement
This study compares different MRI scans for prostate cancer. We want to see if a shorter, simpler MRI without a special dye injection (biparametric MRI) works as well as the standard MRI with the dye (multiparametric MRI) in finding important prostate cancers.
United States · Argentina · Australia - recruitingPHASE3
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
This study is looking at a new treatment called AAA817, combined with standard prostate cancer drugs, for men with advanced prostate cancer. It compares this new combination to existing treatments to see which works best at slowing the cancer's growth.
United States · Australia · Brazil - recruitingNA
Hypofractionated Expedited Radiotherapy for Men With localisEd proState Cancer
This study compares different ways to treat prostate cancer with targeted X-ray therapy. We're looking at whether 2 treatments or 5 treatments work best using a special machine that helps us aim precisely. The goal is to find a shorter, equally safe treatment.
United Kingdom - active not recruitingPHASE3
Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
This study compares two treatments for advanced prostate cancer that has spread and no longer responds to hormone therapy. It tests if adding a new drug, capivasertib, to standard chemotherapy (docetaxel) works better than chemotherapy alone to help patients live longer and keep the cancer from growing.
United States · Australia · Belgium - active not recruitingPHASE3
Prostate Advances in Comparative Evidence
This study looks at different ways to treat prostate cancer, comparing surgery with different types of radiotherapy. It aims to find out which treatments work best for different people, have fewer side effects, and improve quality of life.
Canada · Ireland · New Zealand - recruiting
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment
This study, called PROFILE, explores prostate cancer risk in men. It looks at how family history, ethnicity, and genetics might increase the chance of getting prostate cancer, hoping to find better early detection methods.
United Kingdom - recruiting
The Active Surveillance Study
This study looks at men with prostate cancer on Active Surveillance to see how genetics and body markers might affect their cancer. It compares men with and without a higher genetic risk to understand how their cancer changes over time.
United Kingdom - recruiting
The PROSECCA Study, Answering New Questions in Prostate Cancer
This study uses AI to look at health records of prostate cancer patients. We want to find out how to make radiotherapy better and reduce side effects by personalising treatment for each person, especially those at higher risk of problems.
United Kingdom