A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab

To be considered for this study, you need to be an adult, aged 18 or older. You must have been diagnosed with chronic rhinosinusitis with nasal polyps for at least a year, and your condition needs to be severe enough that surgery has been discussed as an option. This is usually checked by measuring your nasal polyp size and how stuffy your nose feels.

Your nasal polyps should be causing ongoing symptoms like a runny nose, problems with smell, or poor sleep for at least two months. You also need to have tried standard treatments, including nasal sprays containing steroids, and have been using them regularly for at least a month before joining the study.

Additionally, you should have either had a steroid treatment (like tablets or an injection) for your polyps in the last year (but not in the last three months), or have a history of nasal polyp surgery. The study also has some specific requirements regarding female participants' ability to become pregnant, or if they are postmenopausal.

If you join this study, the total time you'd be involved is up to 40 weeks, which is about 9-10 months. You'll receive the study medicine, tezepelumab, for 24 weeks. During this treatment period, you'll have visits to the study clinic about every 4 weeks. These visits are important for the doctors to check how you're doing, understand if the medicine is helping your symptoms, and monitor your safety.

During these appointments, the study team will ask you questions about your symptoms, specifically how blocked your nose feels and your overall sinus experience. They will use special questionnaires to track these changes. After the 24 weeks of treatment, there will be a follow-up period of about 12 weeks to continue monitoring your health and any long-term effects of the medicine.