Chronic Rhinosinusitis with Nasal Polyps research hub
13 indexed studies · 6 currently recruiting
- authorisedTherapeutic use (Phase IV)
Direct comparison of Tezepelumab and Dupilumab in CRSwNP in a real world setting
This study compares two medicines, Dupixent and Tezspire, for treating long-term nasal polyps. Researchers want to see which medicine works better in real-world use to improve symptoms like stuffy nose and sense of smell over 12 months.
Austria - recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-blind, Placebo-controlled, Multi-center Study to Assess the Efficacy and Safety of Verekitug (UPB-101) in Participants with Chronic Rhinosinusitis with Nasal Polyps on a Background of Nasal Corticosteroids (VIBRANT)
This study is testing a new medicine, Verekitug, for people with long-term stuffy nose and nasal polyps, which are soft growths inside the nose. We want to see if it helps reduce polyps and other symptoms.
Germany · Czechia · Spain - recruitingTherapeutic use (Phase IV)
Treatment of non-type 2 CRSwNP with anti-IL-17 antibody (secukinumab)
This study is looking at how a medicine called Cosentyx (secukinumab) might help adults with severe long-term sinus problems and nasal polyps, specifically when other treatments haven't worked well. It aims to see if Cosentyx can improve symptoms and reduce polyps.
Estonia - recruitingTherapeutic use (Phase IV)
A phase IV, randomized double blinded placebo-controlled study on the barrier restoring capacity of Dupilumab in type 2 airway disease: CRSwNP
This study is looking at how a medicine called Dupixent (Dupilumab) might help people with long-term stuffy nose and growths called nasal polyps. We want to see if it helps fix the natural barrier in the nose lining.
Belgium - authorisedTherapeutic confirmatory (Phase III)
A double-blinded extension study to evaluate the long-term safety and tolerability of itepekimab in adult participants with inadequately controlled chronic rhinosinusitis with nasal polyps (CRSwNP) who participated in either EFC18418 or EFC18419 clinical studies
This study is looking at the long-term safety of a new medicine, itepekimab, for adults with nose polyps and ongoing sinus problems. It's for people who were in earlier trials and helps us understand if the treatment is safe over time.
Germany · Netherlands · Portugal - enrolling by invitationPHASE2
Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Clinical Study
This study looks at how safe and effective a medicine called lunsekimig is over a long time for adults with long-lasting nose and sinus problems, especially those with nasal polyps, who have already used lunsekimig in a previous study.
United States · Argentina · Belgium - active not recruitingPHASE3
An Extension Study to Investigate the Long-term Safety and Tolerability of Itepekimab in Adult Participants With Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps
This study looks at the long-term safety and effects of a medicine called itepekimab for adults with a condition called chronic rhinosinusitis with nasal polyps, which causes stuffy nose and other symptoms. This is an extension study for people who were already in an earlier trial.
United States · Argentina · Australia - recruitingPHASE4
Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposis
This study looks at how a medicine called Dupilumab helps people with nasal polyps smell better. It measures changes in sense of smell over six months for adults already taking Dupilumab for their condition.
Canada - active not recruitingPHASE3
A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab
This study looks at how a new medicine, tezepelumab, helps adults in the UK with a blocked nose and other problems caused by long-lasting sinus issues and nasal polyps. It checks if their symptoms improve over 24 weeks of treatment.
United States · Bulgaria · Canada - recruitingPHASE4
Identifying Predictors Of Response To Mepolizumab In CRSwNP
This study looks into why some people with severe nose polyps get lasting relief from mepolizumab, even after treatment stops. We're trying to understand how it works and find ways to predict who will benefit most.
Canada - active not recruitingPHASE4
Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients with CRS
This study is looking at whether a medicine called celecoxib can help people with sinus problems and aspirin allergy feel better after surgery. We want to see if it reduces pain and swelling, making recovery easier without causing new issues.
Canada · Saudi Arabia - active not recruitingPHASE3
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
This study looks at a new medicine called Itepekimab for people with long-term sinus problems and nasal polyps. It checks if the medicine works, is safe, and if people can tolerate it well, compared to a dummy medicine or standard nasal spray.
United States · Argentina · Austria - active not recruitingPHASE3
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
This study is testing a new drug, itepekimab, for people with long-term sinus problems and nasal polyps that haven't been controlled by usual treatments. We want to see if it helps reduce symptoms and if it's safe to use.
United States · Argentina · Australia