Testing a new microchip system to detect bowel cancer markers in blood and stool samples
This study is looking at a new microchip system that can detect signs of bowel cancer in blood and poo samples. Bowel cancer is a serious illness, and finding it early can make a big difference to treatment and recovery. Current tests aren't always accurate, sometimes missing cancer or leading to unnecessary follow-up procedures like colonoscopies. The new microchip aims to quickly and easily find tiny pieces of cancer DNA in your samples. This could help doctors diagnose cancer earlier, guide treatment choices, and keep an eye on how well treatments are working. We're inviting adults who have already been diagnosed with bowel cancer to take part by providing blood and poo samples.
At a glance
What is this study about?
Bowel cancer is a major health concern, and catching it early is really important for good treatment outcomes. Right now, it can be tricky to diagnose accurately. Some existing tests aren't always reliable – they might miss cancer, or they might suggest you have cancer when you don't, leading to stressful and sometimes unnecessary procedures like colonoscopies. These procedures can be uncomfortable, have risks, and take up valuable hospital resources. Doctors are looking for better, simpler ways to find bowel cancer.
Cancer cells release tiny bits of their DNA into your blood and poo. This study is testing a brand-new microchip system that can find these specific cancer DNA pieces. Think of it like a smart detector looking for very particular clues. If successful, this technology could mean a quick, easy, and non-invasive test that can be done right in a clinic, rather than needing long, complex lab work. This could not only help find cancer earlier but also help doctors choose the best, most personalized treatment for each patient and monitor how well that treatment is working.
The main goal of this small, initial study is to see how well this new microchip can detect these cancer-related DNA markers in blood and poo samples from people who already have bowel cancer. Your participation would help us understand if this new technology works as expected, paving the way for it to potentially help many more people in the future.
Key takeaways
- Tests a new microchip for finding bowel cancer signs.
- Aims for earlier and more accurate cancer detection.
- Will use blood and poo samples (not invasive procedures).
- For adults already diagnosed with bowel cancer.
- No direct benefit to you, but helps future patients.
- Low risk, mainly involves a blood test.
Who may be eligible?
To be able to take part in this study, you need to be an adult, aged 18 years or older, who has received a diagnosis of bowel cancer. This diagnosis must have been confirmed by a biopsy (where a small piece of tissue is taken for examination).
It doesn't matter what stage your bowel cancer is at – we are including patients with bowel cancer at any stage. You also need to be willing to understand the study information and agree to take part.
Key things that would mean you can't join the study include being under 18 years old or if you are unable to provide your consent to participate.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Have you been diagnosed with bowel cancer?
- Has your bowel cancer diagnosis been confirmed by a biopsy?
- Are you able to give your informed consent to participate?
What does participation involve?
If you decide to take part in this study, the process will be quite straightforward. First, your current care team, with your permission, might check if you meet the study requirements. If you're interested in learning more, the research team will contact you and provide all the details about the study.
Once you agree to join, we will ask you to provide two types of samples: a small sample of your blood and a stool (poo) sample. We will then extract the DNA from these samples and use the new microchip device to see if it can find any genetic markers linked to bowel cancer. After these tests are done, all your samples will be safely discarded. There will be no further appointments or follow-up procedures required for this study beyond providing these samples.
Potential risks and benefits
Locations (1)
- Cambridge University Hospitals NHS Foundation TrustCity onlyCambridge, England
Common questions
What is a 'microchip system' in this study?
It's a new, tiny device designed to quickly find specific DNA markers from bowel cancer cells in your blood and poo samples.
What are 'cancer markers'?
These are specific bits of DNA released by cancer cells that can act as clues for detecting the presence of cancer.
Will I get any specific treatment or medicine?
No, this study is about testing a new detection method, not a new treatment. You will continue to receive your usual medical care.
Do I need to do anything special before giving samples?
The research team will provide you with full instructions for collecting your blood and poo samples.
Where does the study take place?
You will be recruited through Cambridge University Hospitals NHS Foundation Trust. The sample testing will happen in labs at Imperial College London, UK.
How to find out more
Constantinos Simillis
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
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