- recruiting
Exploring and understanding the support and care needs of people living with advanced bowel cancer and their carers
The ACRE study looks into the support needs of people living with advanced bowel cancer and their carers in Cheshire and Merseyside. Researchers want to find out what help is available, what is missing, and how NHS services can be improved to support patients and families better.
United Kingdom · England - completed
Could supported weight loss reduce bowel cancer surgery complications?
This UK study looks at whether a short, supported weight-loss programme before bowel cancer surgery helps patients recover better. People waiting for surgery will either follow a special low-calorie soup and shake diet with dietitian support for three to four weeks, or continue with their usual hospital care.
United Kingdom · England - completed
Multicentre randomised trial of 'once only' flexible sigmoidoscopy screening for prevention of bowel cancer morbidity and mortality
Bowel cancer is a common cancer in the UK. This long-term study tests whether having a one-off camera test of the lower bowel around age 60 can spot small growths early. Removing these growths helps prevent cancer from starting and aims to save lives over many years.
United Kingdom · England - recruitingPhase I and Phase II (Integrated)- Other
Phase I/II study with galunisertib combined with capecitabine in patients with advanced chemotherapy resistant colorectal cancer with peritoneal metastases
This study tests a new drug combination for advanced bowel cancer that has spread to the tummy lining and no longer responds to standard chemotherapy. Researchers want to find the safest dose of an experimental drug called galunisertib when taken with capecitabine chemotherapy tablets, and see if it shrinks tumours.
Netherlands - authorisedTherapeutic confirmatory (Phase III)
A Randomized, Open-label, Phase 3 Trial of Petosemtamab in Combination With mFOLFOX6 or FOLFIRI Versus Cetuximab in Combination With mFOLFOX6 or FOLFIRI as First-line Treatment for Participants With RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer.
This phase 3 study tests whether a new targeted medicine, petosemtamab, works better than the standard targeted drug, cetuximab, when combined with chemotherapy. It is for adults with advanced, left-sided bowel cancer that has not yet been treated and does not have changes in the RAS or BRAF genes.
Spain - recruitingTherapeutic confirmatory (Phase III)
A Phase 3 study of MK-4280A (coformulated favezelimab [MK-4280] plus pembrolizumab [MK-3475]) Versus Standard of Care in Previously Treated Metastatic PD-L1 positive Colorectal Cancer (KEYFORM-007)
This study looks at a new drug combination, MK-4280A, for bowel cancer that has spread and has been treated before. It compares this new treatment to standard care to see if it helps people live longer and improves their quality of life.
Italy · Norway · France - recruitingTherapeutic exploratory (Phase II)
Phase II trial of Pembrolizumab and Olaparib in homologous-recombination deficient (HRD) advanced colorectal cancer (CRC).
This study looks at a new way to treat advanced bowel cancer that has a specific genetic weakness. It combines two drugs, Pembrolizumab and Olaparib, to see if they can shrink tumours or stop them from growing.
Spain - recruitingTherapeutic use (Phase IV)
Transversus Abdominis Plane (TAP) Block vs. Laparoscopic Port Site Wound Infiltration in Patients with Colorectal Cancer Undergoing Scheduled Laparoscopic Surgery Included in the Enhanced Recovery After Surgery (ERAS) Program
This study compares two ways to help manage pain after keyhole surgery for bowel cancer. It looks at whether injecting pain relief near tummy nerves (TAP block) or around the surgery cuts works best within a special recovery programme.
Spain - recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of AZD0022 Monotherapy and in Combination with Anti-cancer Agents in Participants with Tumours Harbouring a KRASG12D Mutation (ALAFOSS-01)
This study looks at a new drug, AZD0022, for people with certain types of lung, bowel, and pancreatic cancer. Doctors want to see if it's safe, how the body handles it, and if it can help shrink tumours, both on its own and with other cancer drugs.
Belgium · Poland · Italy - recruitingPHASE1, PHASE2
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
This study looks at a new drug, sacituzumab tirumotecan, alone or with other common treatments for advanced bowel, pancreatic, and bile duct cancers. Researchers want to see if it's safe, tolerable, and can shrink these cancers.
United States · Australia · Canada - active not recruitingPHASE2
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
This study looks at a drug called entrectinib for different types of advanced cancer. It focuses on cancers with specific genetic changes (NTRK, ROS1, or ALK gene fusions). Researchers want to see if entrectinib can help treat these cancers.
United States · Australia · Belgium - active not recruitingPHASE3
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer
This study compares two treatments, XL092 (plus atezolizumab) and regorafenib, for advanced bowel cancer that has spread. It's for people whose cancer hasn't responded well to previous common treatments. We want to see which treatment works better to control the cancer.
United States · Australia · Belgium - recruitingNA
Optimizing Patient Treatment With EPA-enriched Nutrition, a Randomised Control Trial
This study looks at how a special nutritional drink, Fortimel Forticare Sensations (FFS), affects people with lung or bowel cancer who are struggling with malnutrition. FFS contains helpful omega-3 fats, protein, and calories. Researchers want to see if it improves their health, weight, and quality of life.
Norway · United Kingdom - recruitingPHASE1, PHASE2
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
This study is looking at a new drug called MCLA-158 for advanced cancers like bowel and head and neck cancer. It aims to find the safest dose and see how well it works alone or with other treatments. It's for patients whose cancer has spread or come back.
United States · Belgium · France - completed
Pathology Artificial-Intelligence Clinical Evaluation Study
This study looks at whether artificial intelligence (AI) can help doctors diagnose and treat bowel cancer more effectively. Researchers will test AI computer tools on digital pictures of tissue samples already collected during standard NHS care. Taking part will not change your treatment plan or require extra hospital visits.
United Kingdom · England - completed
Short term Water-only Fasting prior to chemotherapy Trial (SWiFT)
The SWiFT study looks at whether people having chemotherapy for bowel cancer can safely fast for 36 hours before treatment. Researchers want to know if drinking only water for a short time is practical, safe, and whether it might help protect healthy cells and reduce unwanted side effects.
United Kingdom · England - completed
A feasibility study of electron radiotherapy delivered during a surgical operation for rectal cancer
This study looks at giving targeted radiotherapy directly into the pelvis during surgery for rectal cancer. Doctors want to see if treating the area during the operation helps destroy any leftover cancer cells, lowering the chance of the cancer returning while keeping the treatment safe for patients.
United Kingdom · England - recruitingTherapeutic exploratory (Phase II)
Randomized Phase 2 Study of DKN-01 Plus FOLFIRI/FOLFOX and Bevacizumab Versus FOLFIRI/FOLFOX and Bevacizumab as Second-line Treatment of Advanced Colorectal Cancer (DeFianCe)
This study looks at a new drug, DKN-01, combined with standard treatments for advanced bowel cancer. It compares this new combination to the standard treatments alone, to see if it helps people live longer without their cancer growing.
Germany - recruitingTherapeutic exploratory (Phase II)
Calcium electroporation in combination with irreversible electroporation and immunotherapy in patients with pMMR metastatic colorectal cancer - A prospective, phase 2 study
This study is looking at a new way to treat bowel cancer that has spread. It combines special electrical treatments with an immunotherapy drug, pembrolizumab. Researchers want to see if this combination is safe and how well it works together.
Denmark - recruitingHuman Pharmacology (Phase I)- First administration to humans
AN OPEN-LABEL, MULTICENTER, PHASE 1a/1b STUDY OF IGM-8444 AS A SINGLE AGENT AND IN COMBINATION IN SUBJECTS WITH RELAPSED, REFRACTORY, OR NEWLY DIAGNOSED CANCERS
This study is testing a new medicine called IGM-8444 for certain cancers, including bowel cancer. It's an early-stage study to see if the medicine is safe and how it works, both on its own and with other treatments. It's for people whose cancer has come back, hasn't responded to other treatments, or has been recently diagnosed.
Spain · France - recruitingPhase I and Phase II (Integrated)- Other
CA209-8KX Phase I/II pharmacokinetic multi-tumor study of subcutaneous formulation of nivolumab monotherapy
This study is looking at a new way to give nivolumab, a cancer medicine, through an injection under the skin. It's for people with various advanced cancers like lung, kidney, and liver cancer, to see how the body handles the medicine and if it's safe.
Spain · Netherlands · Italy - recruitingNot Applicable
Testing a new microchip system to detect bowel cancer markers in blood and stool samples
This study is testing a new microchip to find signs of bowel cancer in blood and poo samples. It aims to detect cancer early and help doctors give better, more personal treatments. It’s for adults diagnosed with bowel cancer.
United Kingdom · England - recruitingPHASE1, PHASE2
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
This study is testing a new medicine called S241656 for people with certain advanced cancers, including lung, bowel, and pancreatic cancers. It aims to find a safe and effective dose, either alone or with other treatments, for cancers with specific genetic changes.
United States · Australia · China - recruitingNA
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
This study compares two ways to check for colon polyps in people aged 65-82: a bowel scope (colonoscopy) or a simple stool test. We want to see which method works best and is safest for older adults who've had polyps before.
United States · Canada - active not recruitingPHASE2
A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver
This study looks at a new drug, QBECO, for bowel cancer that has spread to the liver. It aims to see if QBECO, given before and after surgery, can reduce the chance of the cancer growing or coming back, compared to a dummy drug.
Canada - recruitingPHASE1, PHASE2
Evaluation of 89Zr-DFO-nimotuzumab for Non-invasive Imaging of EGFR+ Cancers by Positron Emission Tomography (PET)
This study looks for a better way to find specific cancer cells (EGFR-positive) in lung and bowel cancers. We use a special scan (PET) after giving a small amount of a test medicine to see if it lights up these cancer cells, helping doctors choose the best treatments.
Canada - recruitingPHASE1, PHASE2
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
This study looks at a new drug, zongertinib, for different HER2+ cancers that have spread. Researchers want to find the best dose, alone and with other treatments, to see if it can shrink tumours.
United States · Belgium · China - active not recruitingNA
Diagnostic Value of Diffusion-weighted Magnetic Resonance in High-risk Colorectal and Appendiceal Neoplasms
This study looks at a special MRI scan to find cancer spread in the tummy for people who have had bowel or appendix cancer. It aims to see if this scan is better than current methods at spotting problems early, helping doctors plan the best treatment.
Canada - active not recruiting
Comprehensive Genomic Profiling of Colorectal Cancer Patients With Isolated Liver Metastases to Understand Response & Resistance to Cancer Therapy
This study looks at bowel cancer that has spread only to the liver. Researchers want to understand why some treatments work better for some people and to find new ways to predict how the cancer might behave and what treatments might be best.
Canada - active not recruitingNA
Use of Alternative and Complementary Medicine by Colorectal Cancer Patients
This study aims to understand if and why people in France with bowel (colorectal) cancer use extra treatments alongside or instead of their standard medical care. Researchers will ask about different therapies like acupuncture, special diets, or herbal remedies, to see how common these are and why patients choose them.
France - active not recruitingPHASE1
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab
This study looks at a new drug, ABBV-400, for advanced cancers like lung and bowel cancer. We're checking how safe it is and if it helps shrink tumours, both on its own and with another drug.
United States · Australia · France - recruitingPHASE1, PHASE2
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
This study is looking at two new medicines, Elironrasib and Daraxonrasib, for people with advanced cancers that have a specific genetic change called KRAS G12C. Researchers want to see if these medicines are safe and how well they work, both alone and together.
United States · France · Germany - recruiting
ColoReg: A Register for Gastrointestinal Endoscopy Reports and Examination Videos
This study aims to create a collection of endoscopy reports and videos to improve how doctors learn, for research, and to check the quality of care for bowel conditions. It will help ensure treatments are effective and safe, and train new doctors better.
Germany - recruiting
Multicentre Study for Data Collection, Development, and Evaluation of Novel CRC Screening and Diagnostic Methods
This study aims to find new, easy, and affordable ways to test for bowel cancer, especially for people at higher risk. The goal is to detect cancer earlier using new screening methods that are simple to use.
Bulgaria · France · Germany - recruitingNA
Postoperative Electrical Muscle Stimulation Two
This study looks at whether electrical muscle stimulation and protein drinks can help people keep their muscle strength after major tummy surgery for cancer. Losing muscle can make it harder to get back to normal activities, so researchers want to find ways to prevent it.
United Kingdom - not yet recruitingNA
Assessment of Adherence to Remotely Monitored Physical Activity Tracked on a Smartwatch, and Its Impact on Reducing Fatigue 3 Months After Adjuvant Chemotherapy for Cancer
This study looks at how well people with certain cancers stick to a special exercise program after chemotherapy. It uses smartwatches to track activity and checks if exercise helps reduce tiredness three months later.
France - recruitingPHASE1
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
This study is testing a new drug, VVD-133214, for advanced solid tumours, including a type of bowel cancer. It looks at safety, how the body handles the drug, and if it can help shrink tumours. It's an early-stage study, sometimes testing the new drug with other standard treatments.
United States · Australia · Belgium - not yet recruitingNA
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients
This study looks at using a special type of electrical muscle stimulation (like gentle zaps) on the whole body, combined with healthy eating advice. It's for people with certain tummy and bowel cancers to see if it helps build muscle and improve energy better than exercise alone.
Germany - active not recruitingPHASE1
Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer
This study looks at new treatments for advanced bowel cancer that has spread. It tests a new vaccine (ATP128), a drug called BI 754091, and sometimes another vaccine (VSV-GP128), both alone and in combinations, to see if they are safe and how well people tolerate them.
United States · Belgium · Germany - recruiting
Comparison of the Physical Activity in Cancer Patients Assessed by Questionnaire and Motion Tracker
This study looks at how we measure physical activity in people with lymphoma, pancreatic, or bowel cancer. It compares questionnaires with motion trackers to see which works best. The aim is to find better ways to understand how active cancer patients are.
Germany - active not recruitingPHASE1, PHASE2
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
This study is looking into a new drug, MCLA-129, for some advanced cancers like lung or stomach cancer. It will see how safe and effective it is, both by itself and with other treatments. It's for people who haven't responded to previous treatments.
United States · Belgium · France - recruitingPHASE1
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
This study is testing a new drug, ASP5834, for adults with certain solid cancers. It aims to find the right dose and check for side effects, sometimes given with another cancer drug called panitumumab, especially for bowel cancer.
United States · France · Japan - recruiting
Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.
This study looks at whether we can find signs of non-bowel cancers, like lung or pancreatic cancer, in a small sample of mucus taken from a person's bottom. We're testing a new, simple device to see if it can help detect these cancers earlier.
United Kingdom - recruitingPHASE1
FIH, Bispecific CD276xCD3 Antibody CC-3 in Patients With Colorectal Cancer
This study is testing a new medicine called CC-3 for people with advanced bowel, breast, or other cancers that haven't responded to usual treatments. It aims to see if CC-3 is safe and effective in fighting cancer by helping the body's immune system target cancer cells.
Germany - active not recruiting
First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer
This study looks at a new way to check if bowel cancer has completely gone after surgery. It involves regular blood tests for up to five years for people who have had their stage 2 or 3 bowel cancer removed. Doctors hope to find very small amounts of cancer cells to help improve treatment.
Israel · Italy · Japan - recruiting
COLON-IM : Microbiota and Immune Infiltrate in Normal, Dysplastic and Neoplastic Colorectal Tissue
This study, called COLON-IM, is looking at gut bacteria and immune cells in healthy and cancerous bowel tissue. It aims to understand how these parts of your body might contribute to bowel cancer development and how they could be used to improve future treatments.
France - recruiting
The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling
This study is developing new blood tests for early cancer detection and to monitor how well treatment is working. It uses artificial intelligence to look at tiny particles in blood samples from people with various cancers and healthy volunteers.
Argentina · Nigeria · United Kingdom - recruitingPHASE3
Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)
This study looks at adding chemotherapy after surgery for advanced bowel cancer that has spread. We want to see if extra treatment improves how long people stay well and their quality of life, compared to just regular check-ups.
Germany - recruitingNA
Chemo Brain Prehab Project
This study looks at whether a special exercise programme can help older people with colorectal cancer who are having chemotherapy. It aims to reduce 'chemo-brain' – problems with memory and thinking – and improve how well people feel overall during and after treatment.
United Kingdom - recruitingPHASE1, PHASE2
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
This study looks at a new drug, IDE196, for certain advanced cancers that have specific genetic changes called GNAQ/11 mutations or PRKC fusions. It checks if the drug is safe and effective alone or when combined with other existing cancer drugs.
United States · Australia · Canada