Non-small Cell Lung Cancer research hub
50 indexed studies · 34 currently recruiting
- recruitingPHASE1, PHASE2
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
This study is testing a new medicine called S241656 for people with certain advanced cancers, including lung, bowel, and pancreatic cancers. It aims to find a safe and effective dose, either alone or with other treatments, for cancers with specific genetic changes.
United States · Denmark · Hong Kong - active not recruitingPHASE2
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
This study looks at a drug called entrectinib for different types of advanced cancer. It focuses on cancers with specific genetic changes (NTRK, ROS1, or ALK gene fusions). Researchers want to see if entrectinib can help treat these cancers.
United States · Australia · Belgium - active not recruitingPHASE1
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
This study is testing a new medicine, GDC-6036, for people with advanced cancers that have a specific genetic change called KRAS G12C. It will look at how safe the medicine is and if it helps shrink tumors, sometimes combined with other treatments.
United States · Australia · Belgium - recruitingPHASE1, PHASE2
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
This study looks at a new drug, sacituzumab tirumotecan, alone or with other common treatments for advanced bowel, pancreatic, and bile duct cancers. Researchers want to see if it's safe, tolerable, and can shrink these cancers.
United States · Australia · Canada - recruitingPHASE1
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
This study is testing a new drug, VVD-133214, for advanced solid tumours, including a type of bowel cancer. It looks at safety, how the body handles the drug, and if it can help shrink tumours. It's an early-stage study, sometimes testing the new drug with other standard treatments.
United States · Australia · Belgium - recruitingPHASE2
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
This study looks at a new drug, Dato-DXd, by itself and with other treatments for different advanced cancers like those affecting the stomach, ovaries, and prostate. It checks if the treatment is safe and effective.
United States · Canada · China - recruitingPHASE1, PHASE2
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
This study is looking at a new drug called MCLA-158 for advanced cancers like bowel and head and neck cancer. It aims to find the safest dose and see how well it works alone or with other treatments. It's for patients whose cancer has spread or come back.
United States · Belgium · France - ongoing, recruitingTherapeutic exploratory (Phase II)
Randomized Phase 2 Study of DKN-01 Plus FOLFIRI/FOLFOX and Bevacizumab Versus FOLFIRI/FOLFOX and Bevacizumab as Second-line Treatment of Advanced Colorectal Cancer (DeFianCe)
This study looks at a new drug, DKN-01, combined with standard treatments for advanced bowel cancer. It compares this new combination to the standard treatments alone, to see if it helps people live longer without their cancer growing.
Germany - active not recruitingPHASE2
A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver
This study looks at a new drug, QBECO, for bowel cancer that has spread to the liver. It aims to see if QBECO, given before and after surgery, can reduce the chance of the cancer growing or coming back, compared to a dummy drug.
Canada - recruitingNA
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
This study compares two ways to check for colon polyps in people aged 65-82: a bowel scope (colonoscopy) or a simple stool test. We want to see which method works best and is safest for older adults who've had polyps before.
United States · Canada - recruitingPHASE1, PHASE2
Evaluation of 89Zr-DFO-nimotuzumab for Non-invasive Imaging of EGFR+ Cancers by Positron Emission Tomography (PET)
This study looks for a better way to find specific cancer cells (EGFR-positive) in lung and bowel cancers. We use a special scan (PET) after giving a small amount of a test medicine to see if it lights up these cancer cells, helping doctors choose the best treatments.
Canada - active not recruitingNA
Diagnostic Value of Diffusion-weighted Magnetic Resonance in High-risk Colorectal and Appendiceal Neoplasms
This study looks at a special MRI scan to find cancer spread in the tummy for people who have had bowel or appendix cancer. It aims to see if this scan is better than current methods at spotting problems early, helping doctors plan the best treatment.
Canada - active not recruiting
Comprehensive Genomic Profiling of Colorectal Cancer Patients With Isolated Liver Metastases to Understand Response & Resistance to Cancer Therapy
This study looks at bowel cancer that has spread only to the liver. Researchers want to understand why some treatments work better for some people and to find new ways to predict how the cancer might behave and what treatments might be best.
Canada - active not recruitingNA
Use of Alternative and Complementary Medicine by Colorectal Cancer Patients
This study aims to understand if and why people in France with bowel (colorectal) cancer use extra treatments alongside or instead of their standard medical care. Researchers will ask about different therapies like acupuncture, special diets, or herbal remedies, to see how common these are and why patients choose them.
France - active not recruitingPHASE1
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab
This study looks at a new drug, ABBV-400, for advanced cancers like lung and bowel cancer. We're checking how safe it is and if it helps shrink tumours, both on its own and with another drug.
United States · Australia · France - recruitingPHASE1, PHASE2
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
This study is looking at two new medicines, Elironrasib and Daraxonrasib, for people with advanced cancers that have a specific genetic change called KRAS G12C. Researchers want to see if these medicines are safe and how well they work, both alone and together.
United States · France · Germany - recruiting
ColoReg: A Register for Gastrointestinal Endoscopy Reports and Examination Videos
This study aims to create a collection of endoscopy reports and videos to improve how doctors learn, for research, and to check the quality of care for bowel conditions. It will help ensure treatments are effective and safe, and train new doctors better.
Germany - recruiting
Multicentre Study for Data Collection, Development, and Evaluation of Novel CRC Screening and Diagnostic Methods
This study aims to find new, easy, and affordable ways to test for bowel cancer, especially for people at higher risk. The goal is to detect cancer earlier using new screening methods that are simple to use.
Bulgaria · France · Germany - recruitingNA
Postoperative Electrical Muscle Stimulation Two
This study looks at whether electrical muscle stimulation and protein drinks can help people keep their muscle strength after major tummy surgery for cancer. Losing muscle can make it harder to get back to normal activities, so researchers want to find ways to prevent it.
United Kingdom - not yet recruitingNA
Assessment of Adherence to Remotely Monitored Physical Activity Tracked on a Smartwatch, and Its Impact on Reducing Fatigue 3 Months After Adjuvant Chemotherapy for Cancer
This study looks at how well people with certain cancers stick to a special exercise program after chemotherapy. It uses smartwatches to track activity and checks if exercise helps reduce tiredness three months later.
France - not yet recruitingNA
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients
This study looks at using a special type of electrical muscle stimulation (like gentle zaps) on the whole body, combined with healthy eating advice. It's for people with certain tummy and bowel cancers to see if it helps build muscle and improve energy better than exercise alone.
Germany - active not recruitingPHASE1
Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer
This study looks at new treatments for advanced bowel cancer that has spread. It tests a new vaccine (ATP128), a drug called BI 754091, and sometimes another vaccine (VSV-GP128), both alone and in combinations, to see if they are safe and how well people tolerate them.
United States · Belgium · Germany - recruiting
Comparison of the Physical Activity in Cancer Patients Assessed by Questionnaire and Motion Tracker
This study looks at how we measure physical activity in people with lymphoma, pancreatic, or bowel cancer. It compares questionnaires with motion trackers to see which works best. The aim is to find better ways to understand how active cancer patients are.
Germany - active not recruitingPHASE1, PHASE2
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
This study is looking into a new drug, MCLA-129, for some advanced cancers like lung or stomach cancer. It will see how safe and effective it is, both by itself and with other treatments. It's for people who haven't responded to previous treatments.
United States · Belgium · France - recruitingPHASE1
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
This study is testing a new drug, ASP5834, for adults with certain solid cancers. It aims to find the right dose and check for side effects, sometimes given with another cancer drug called panitumumab, especially for bowel cancer.
United States · France · Japan - recruiting
Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.
This study looks at whether we can find signs of non-bowel cancers, like lung or pancreatic cancer, in a small sample of mucus taken from a person's bottom. We're testing a new, simple device to see if it can help detect these cancers earlier.
United Kingdom - recruitingPHASE1, PHASE2
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
This study looks at a new drug, zongertinib, for different HER2+ cancers that have spread. Researchers want to find the best dose, alone and with other treatments, to see if it can shrink tumours.
United States · Belgium · China - recruitingPHASE1
FIH, Bispecific CD276xCD3 Antibody CC-3 in Patients With Colorectal Cancer
This study is testing a new medicine called CC-3 for people with advanced bowel, breast, or other cancers that haven't responded to usual treatments. It aims to see if CC-3 is safe and effective in fighting cancer by helping the body's immune system target cancer cells.
Germany - active not recruiting
First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer
This study looks at a new way to check if bowel cancer has completely gone after surgery. It involves regular blood tests for up to five years for people who have had their stage 2 or 3 bowel cancer removed. Doctors hope to find very small amounts of cancer cells to help improve treatment.
Israel · Italy · Japan - recruiting
COLON-IM : Microbiota and Immune Infiltrate in Normal, Dysplastic and Neoplastic Colorectal Tissue
This study, called COLON-IM, is looking at gut bacteria and immune cells in healthy and cancerous bowel tissue. It aims to understand how these parts of your body might contribute to bowel cancer development and how they could be used to improve future treatments.
France - recruiting
The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling
This study is developing new blood tests for early cancer detection and to monitor how well treatment is working. It uses artificial intelligence to look at tiny particles in blood samples from people with various cancers and healthy volunteers.
Argentina · Nigeria · United Kingdom - recruitingPHASE3
Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)
This study looks at adding chemotherapy after surgery for advanced bowel cancer that has spread. We want to see if extra treatment improves how long people stay well and their quality of life, compared to just regular check-ups.
Germany - not yet recruitingNA
Chemo Brain Prehab Project
This study looks at whether a special exercise programme can help older people with colorectal cancer who are having chemotherapy. It aims to reduce 'chemo-brain' – problems with memory and thinking – and improve how well people feel overall during and after treatment.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Calcium electroporation in combination with irreversible electroporation and immunotherapy in patients with pMMR metastatic colorectal cancer - A prospective, phase 2 study
This study is looking at a new way to treat bowel cancer that has spread. It combines special electrical treatments with an immunotherapy drug, pembrolizumab. Researchers want to see if this combination is safe and how well it works together.
Denmark - recruitingPHASE1, PHASE2
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
This study looks at a new drug, IDE196, for certain advanced cancers that have specific genetic changes called GNAQ/11 mutations or PRKC fusions. It checks if the drug is safe and effective alone or when combined with other existing cancer drugs.
United States · Australia · Canada - ongoing, recruitingPhase I and Phase II (Integrated)- Other
CA209-8KX Phase I/II pharmacokinetic multi-tumor study of subcutaneous formulation of nivolumab monotherapy
This study is looking at a new way to give nivolumab, a cancer medicine, through an injection under the skin. It's for people with various advanced cancers like lung, kidney, and liver cancer, to see how the body handles the medicine and if it's safe.
Spain · Netherlands · Italy - recruitingPHASE2
SBRT of Metastases Following Neo-adjuvant Treatment for Colorectal Cancer With Synchronous Liver Metastases
This study looks at using a special type of radiation, called SBRT, for liver tumours in people with bowel cancer. It's for patients who have these liver tumours at the same time as their bowel cancer and have already had some initial treatment.
Canada - recruitingPHASE1
Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)
This study is testing a new drug, RGT-61159, for people with advanced adenoid cystic carcinoma (ACC) or colorectal cancer (CRC). It aims to see if the drug is safe and helps shrink tumors. It's for patients whose cancer has come back or spread and who have run out of other treatment options.
United States · Canada - active not recruitingPHASE3
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer
This study compares two treatments, XL092 (plus atezolizumab) and regorafenib, for advanced bowel cancer that has spread. It's for people whose cancer hasn't responded well to previous common treatments. We want to see which treatment works better to control the cancer.
United States · Australia · Belgium - recruiting
LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study
This study looks at how new cancer treatments affect daily life for people with long-term cancer. It aims to understand how to best support them while they are on these treatments, often for many months or years.
Canada - recruitingNA
Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps
This study compares different ways to treat large bowel growths (polyps) to see which method causes fewer problems. It looks at whether closing the area after removing the polyp helps reduce complications or if leaving it open is just as safe.
Canada - recruitingNA
Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases
This study looks at using a liver transplant from a living donor for certain people with bowel cancer that has spread to the liver when surgery isn't an option. It aims to see if this treatment can help them live longer and better.
Canada - recruitingPHASE2
A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer
This study looks at new drug combinations for advanced bowel cancer that hasn't spread widely. Researchers want to see if adding ONO-4578 and Opdivo® to standard treatment helps more than standard treatment alone. It's for people whose cancer creates a specific protein called PD-L1.
United States · Canada · France - active not recruitingPHASE2
Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer
This study looks at different ways to combine radiation and chemotherapy before surgery for stage 2 or 3 bowel cancer. Doctors hope to shrink tumours, making surgery easier and more successful. It compares various treatment plans to see which works best.
United States · Canada - recruitingPHASE3
Intraoperative Indocyanine Green Fluorescence Angiography in Colorectal Surgery to Prevent Anastomotic Leakage
This study looks at a special dye used during colorectal cancer surgery. The dye helps surgeons see blood flow better, which might prevent a complication called anastomotic leak. This is when the joined parts of the bowel don't heal properly.
France - recruitingNA
Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
This study looks at new ways to stop large bowel polyps from coming back after they've been removed. We're comparing two techniques, h-APC and STSC, to see which one is better at preventing these polyps, which can sometimes turn into cancer, from recurring.
Canada - recruiting
ColoCare Study - Colorectal Cancer Cohort
The ColoCare study looks at how bowel cancer affects people. Researchers are collecting samples and information from patients with bowel cancer to understand better why some people do well and how treatments affect their lives. This helps improve care for future patients.
United States · Germany - active not recruitingPHASE3
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
This study looks at whether taking aspirin daily after cancer treatment can stop cancer coming back and help people live longer. It focuses on common cancers like breast, bowel, and prostate cancer.
Ireland · United Kingdom - recruitingPHASE2
Futibatinib in Combination With (Chemo)Immunotherapy in Colorectal Cancer and Other Solid Tumor Entities
This study looks at combining a new medicine, futibatinib, with standard chemotherapy and immunotherapy (tislelizumab) for people with advanced bowel cancer. It checks how well it works and if it's safe as a first treatment, also exploring ways to predict who might benefit most.
Germany - recruitingNA
Trimodal Prehabilitation in Colorectal Cancer Patients
This study looks at how a special program before bowel cancer surgery helps patients. It combines exercise, healthy eating advice, and ways to stay calm. The aim is to see if this program can be easily run and if it helps patients recover better.
Canada