- ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 study of MK-4280A (coformulated favezelimab [MK-4280] plus pembrolizumab [MK-3475]) Versus Standard of Care in Previously Treated Metastatic PD-L1 positive Colorectal Cancer (KEYFORM-007)
This study looks at a new drug combination, MK-4280A, for bowel cancer that has spread and has been treated before. It compares this new treatment to standard care to see if it helps people live longer and improves their quality of life.
Italy · Norway · France - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - recruiting
COLO-COHORT (Colorectal Cancer Cohort) Study
This study aims to find better ways to predict who is at high risk of bowel cancer or pre-cancerous growths. Researchers will look at health factors, new stool tests, and gut bacteria to create a more accurate risk prediction tool, helping to detect problems earlier.
United Kingdom - recruitingPHASE1, PHASE2
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
This study looks at a new drug, sacituzumab tirumotecan, alone or with other common treatments for advanced bowel, pancreatic, and bile duct cancers. Researchers want to see if it's safe, tolerable, and can shrink these cancers.
United States · Australia · Canada - active not recruiting
Cancer Surveillance and Support
This study helps people who have had breast or bowel cancer after their treatment. It looks at using an online system for survivors to report health changes from home and get quick advice. The goal is better support and faster help when needed.
United Kingdom - authorisedTherapeutic use (Phase IV)
Transversus Abdominis Plane (TAP) Block vs. Laparoscopic Port Site Wound Infiltration in Patients with Colorectal Cancer Undergoing Scheduled Laparoscopic Surgery Included in the Enhanced Recovery After Surgery (ERAS) Program
This study compares two ways to help manage pain after keyhole surgery for bowel cancer. It looks at whether injecting pain relief near tummy nerves (TAP block) or around the surgery cuts works best within a special recovery programme.
Spain - recruiting
COlorectal BReath Analysis (COBRA2)
This study is developing a new breath test for bowel cancer. It aims to help doctors find bowel cancer earlier, especially in people with unclear symptoms. Detecting it early means treatment can start sooner, improving chances of recovery.
United Kingdom - active not recruitingPHASE2
Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).
This study looks at new drug combinations for advanced bowel cancer that has specific genetic markers (MSI-H or dMMR). It compares these combinations with existing treatments to see if they are more effective and safe for patients.
United States · Belgium · Canada - active not recruitingPHASE1, PHASE2
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.
United States · Australia · Canada - recruitingPHASE1, PHASE2
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
This study is looking at a new drug called MCLA-158 for advanced cancers like bowel and head and neck cancer. It aims to find the safest dose and see how well it works alone or with other treatments. It's for patients whose cancer has spread or come back.
United States · Belgium · France - active not recruitingPHASE1
A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors
This study looks at a new drug called XL092 for advanced solid tumours like kidney, breast, prostate, or bowel cancer. Researchers are testing it alone and with other drugs (Atezolizumab, Avelumab) to see if it's safe, how it works, and if it can help slow down or shrink tumours.
United States · Australia · Belgium - authorisedTherapeutic exploratory (Phase II)
ORGAN SPARING FOR LOCALLY ADVANCED RECTAL CANCER AFTER NEOADJUVANT TREATMENT FOLLOWED BY ELECTROCHEMOTHERAPY - LARC_ DEEP_CANCERS
This study looks at a new way to treat bowel cancer that has spread nearby, using a drug called bleomycin and electric pulses. The aim is to see if this treatment can help avoid surgery and improve outcomes for patients, potentially leading to faster recovery and fewer side effects.
Italy - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of AZD0022 Monotherapy and in Combination with Anti-cancer Agents in Participants with Tumours Harbouring a KRASG12D Mutation (ALAFOSS-01)
This study looks at a new drug, AZD0022, for people with certain types of lung, bowel, and pancreatic cancer. Doctors want to see if it's safe, how the body handles it, and if it can help shrink tumours, both on its own and with other cancer drugs.
Belgium · Poland · Italy - recruitingPHASE2
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
This study looks at a new drug, Dato-DXd, by itself and with other treatments for different advanced cancers like those affecting the stomach, ovaries, and prostate. It checks if the treatment is safe and effective.
United States · Canada · China - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
AN OPEN-LABEL, MULTICENTER, PHASE 1a/1b STUDY OF IGM-8444 AS A SINGLE AGENT AND IN COMBINATION IN SUBJECTS WITH RELAPSED, REFRACTORY, OR NEWLY DIAGNOSED CANCERS
This study is testing a new medicine called IGM-8444 for certain cancers, including bowel cancer. It's an early-stage study to see if the medicine is safe and how it works, both on its own and with other treatments. It's for people whose cancer has come back, hasn't responded to other treatments, or has been recently diagnosed.
Spain · France - recruiting
Tracking Mutations in Cell Free Tumour DNA to Predict Relapse in Early Colorectal Cancer
This study looks at new ways to predict if bowel cancer might come back after surgery using blood tests. It also explores if these blood tests can safely guide chemotherapy decisions, helping some patients avoid unnecessary treatment while keeping it effective for others.
United Kingdom - recruiting
Triple Assay of Rectal Mucus in the Diagnosis of Colorectal Cancer
This study is testing a new Oricol Test for bowel cancer. It looks at a mucus sample from your bottom to find signs of cancer or pre-cancerous growths (polyps) in people referred for urgent checks. The aim is to find a faster, easier way to detect these conditions.
United Kingdom - recruitingNA
Optimising Colorectal Cancer Patient Pathways
This study aims to improve how we check for bowel cancer. We're testing if extra poo samples can help doctors decide who needs more tests, like a colonoscopy, to find cancer earlier and use NHS resources wisely.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
Ipilimumab and nivolumab plus temozolomide and capecitabine for patients with chemo-refractory pMMR, MGMT silenced metastatic colorectal cancer: The MAYA2 trial
This study is looking at a new combination of existing cancer drugs for people with bowel cancer that has spread and hasn't responded to earlier chemotherapy. It aims to see how well these new drug combinations control the cancer when given together.
Denmark - recruiting
REVOLUTION Surgery (REVOLUTION Surgery)
This study looks into why some cancer patients lose weight and muscle, a condition called cachexia. It aims to understand this problem better by gathering information from patients undergoing surgery for certain cancers and comparing it with people having surgery for non-cancer conditions.
United Kingdom - active not recruitingPHASE2
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
This study looks at a drug called entrectinib for different types of advanced cancer. It focuses on cancers with specific genetic changes (NTRK, ROS1, or ALK gene fusions). Researchers want to see if entrectinib can help treat these cancers.
United States · Australia · Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
Phase II trial of Pembrolizumab and Olaparib in homologous-recombination deficient (HRD) advanced colorectal cancer (CRC).
This study looks at a new way to treat advanced bowel cancer that has a specific genetic weakness. It combines two drugs, Pembrolizumab and Olaparib, to see if they can shrink tumours or stop them from growing.
Spain - authorisedTherapeutic exploratory (Phase II)
A phase 2, single arm, open label, study on the safety and feasibility of Liver Isolated Oxaliplatin (LIOX) delivered via arterial access device for treatment of liver metastasis in colorectal cancer patients
This study looks at a new way to treat colorectal cancer that has spread to the liver. It's testing a chemotherapy drug called oxaliplatin delivered directly to the liver to see how safe and effective it is.
Belgium - recruitingNA
Clinical Utility of ctDNA in Detecting Resistance Mechanisms and Delivering Precision Medicine to Cancer Patients
This study looks at a blood test (Marsden360 ctDNA) for people with certain cancers. It checks if the test helps doctors find the best treatments or clinical trials, and if it makes personalised cancer care better within the NHS.
United Kingdom - active not recruitingPHASE1
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
This study is testing a new medicine, GDC-6036, for people with advanced cancers that have a specific genetic change called KRAS G12C. It will look at how safe the medicine is and if it helps shrink tumors, sometimes combined with other treatments.
United States · Australia · Belgium - recruitingPHASE1, PHASE2
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
This study is testing a new medicine called S241656 for people with certain advanced cancers, including lung, bowel, and pancreatic cancers. It aims to find a safe and effective dose, either alone or with other treatments, for cancers with specific genetic changes.
United States · Denmark · Hong Kong - recruitingPHASE1
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
This study is testing a new drug, VVD-133214, for advanced solid tumours, including a type of bowel cancer. It looks at safety, how the body handles the drug, and if it can help shrink tumours. It's an early-stage study, sometimes testing the new drug with other standard treatments.
United States · Australia · Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
Randomized Phase 2 Study of DKN-01 Plus FOLFIRI/FOLFOX and Bevacizumab Versus FOLFIRI/FOLFOX and Bevacizumab as Second-line Treatment of Advanced Colorectal Cancer (DeFianCe)
This study looks at a new drug, DKN-01, combined with standard treatments for advanced bowel cancer. It compares this new combination to the standard treatments alone, to see if it helps people live longer without their cancer growing.
Germany - active not recruitingPHASE2
A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver
This study looks at a new drug, QBECO, for bowel cancer that has spread to the liver. It aims to see if QBECO, given before and after surgery, can reduce the chance of the cancer growing or coming back, compared to a dummy drug.
Canada - recruitingNA
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
This study compares two ways to check for colon polyps in people aged 65-82: a bowel scope (colonoscopy) or a simple stool test. We want to see which method works best and is safest for older adults who've had polyps before.
United States · Canada - recruitingPHASE1, PHASE2
Evaluation of 89Zr-DFO-nimotuzumab for Non-invasive Imaging of EGFR+ Cancers by Positron Emission Tomography (PET)
This study looks for a better way to find specific cancer cells (EGFR-positive) in lung and bowel cancers. We use a special scan (PET) after giving a small amount of a test medicine to see if it lights up these cancer cells, helping doctors choose the best treatments.
Canada - active not recruitingNA
Diagnostic Value of Diffusion-weighted Magnetic Resonance in High-risk Colorectal and Appendiceal Neoplasms
This study looks at a special MRI scan to find cancer spread in the tummy for people who have had bowel or appendix cancer. It aims to see if this scan is better than current methods at spotting problems early, helping doctors plan the best treatment.
Canada - active not recruiting
Comprehensive Genomic Profiling of Colorectal Cancer Patients With Isolated Liver Metastases to Understand Response & Resistance to Cancer Therapy
This study looks at bowel cancer that has spread only to the liver. Researchers want to understand why some treatments work better for some people and to find new ways to predict how the cancer might behave and what treatments might be best.
Canada - active not recruitingNA
Use of Alternative and Complementary Medicine by Colorectal Cancer Patients
This study aims to understand if and why people in France with bowel (colorectal) cancer use extra treatments alongside or instead of their standard medical care. Researchers will ask about different therapies like acupuncture, special diets, or herbal remedies, to see how common these are and why patients choose them.
France - active not recruitingPHASE1
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab
This study looks at a new drug, ABBV-400, for advanced cancers like lung and bowel cancer. We're checking how safe it is and if it helps shrink tumours, both on its own and with another drug.
United States · Australia · France - recruitingPHASE1, PHASE2
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
This study is looking at two new medicines, Elironrasib and Daraxonrasib, for people with advanced cancers that have a specific genetic change called KRAS G12C. Researchers want to see if these medicines are safe and how well they work, both alone and together.
United States · France · Germany - recruiting
ColoReg: A Register for Gastrointestinal Endoscopy Reports and Examination Videos
This study aims to create a collection of endoscopy reports and videos to improve how doctors learn, for research, and to check the quality of care for bowel conditions. It will help ensure treatments are effective and safe, and train new doctors better.
Germany - recruiting
Multicentre Study for Data Collection, Development, and Evaluation of Novel CRC Screening and Diagnostic Methods
This study aims to find new, easy, and affordable ways to test for bowel cancer, especially for people at higher risk. The goal is to detect cancer earlier using new screening methods that are simple to use.
Bulgaria · France · Germany - recruitingNA
Postoperative Electrical Muscle Stimulation Two
This study looks at whether electrical muscle stimulation and protein drinks can help people keep their muscle strength after major tummy surgery for cancer. Losing muscle can make it harder to get back to normal activities, so researchers want to find ways to prevent it.
United Kingdom - not yet recruitingNA
Assessment of Adherence to Remotely Monitored Physical Activity Tracked on a Smartwatch, and Its Impact on Reducing Fatigue 3 Months After Adjuvant Chemotherapy for Cancer
This study looks at how well people with certain cancers stick to a special exercise program after chemotherapy. It uses smartwatches to track activity and checks if exercise helps reduce tiredness three months later.
France - not yet recruitingNA
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients
This study looks at using a special type of electrical muscle stimulation (like gentle zaps) on the whole body, combined with healthy eating advice. It's for people with certain tummy and bowel cancers to see if it helps build muscle and improve energy better than exercise alone.
Germany - active not recruitingPHASE1
Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer
This study looks at new treatments for advanced bowel cancer that has spread. It tests a new vaccine (ATP128), a drug called BI 754091, and sometimes another vaccine (VSV-GP128), both alone and in combinations, to see if they are safe and how well people tolerate them.
United States · Belgium · Germany - recruiting
Comparison of the Physical Activity in Cancer Patients Assessed by Questionnaire and Motion Tracker
This study looks at how we measure physical activity in people with lymphoma, pancreatic, or bowel cancer. It compares questionnaires with motion trackers to see which works best. The aim is to find better ways to understand how active cancer patients are.
Germany - active not recruitingPHASE1, PHASE2
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
This study is looking into a new drug, MCLA-129, for some advanced cancers like lung or stomach cancer. It will see how safe and effective it is, both by itself and with other treatments. It's for people who haven't responded to previous treatments.
United States · Belgium · France - recruitingPHASE1
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
This study is testing a new drug, ASP5834, for adults with certain solid cancers. It aims to find the right dose and check for side effects, sometimes given with another cancer drug called panitumumab, especially for bowel cancer.
United States · France · Japan - recruiting
Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.
This study looks at whether we can find signs of non-bowel cancers, like lung or pancreatic cancer, in a small sample of mucus taken from a person's bottom. We're testing a new, simple device to see if it can help detect these cancers earlier.
United Kingdom - recruitingPHASE1, PHASE2
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
This study looks at a new drug, zongertinib, for different HER2+ cancers that have spread. Researchers want to find the best dose, alone and with other treatments, to see if it can shrink tumours.
United States · Belgium · China - recruitingPHASE1
FIH, Bispecific CD276xCD3 Antibody CC-3 in Patients With Colorectal Cancer
This study is testing a new medicine called CC-3 for people with advanced bowel, breast, or other cancers that haven't responded to usual treatments. It aims to see if CC-3 is safe and effective in fighting cancer by helping the body's immune system target cancer cells.
Germany - active not recruiting
First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer
This study looks at a new way to check if bowel cancer has completely gone after surgery. It involves regular blood tests for up to five years for people who have had their stage 2 or 3 bowel cancer removed. Doctors hope to find very small amounts of cancer cells to help improve treatment.
Israel · Italy · Japan - recruiting
COLON-IM : Microbiota and Immune Infiltrate in Normal, Dysplastic and Neoplastic Colorectal Tissue
This study, called COLON-IM, is looking at gut bacteria and immune cells in healthy and cancerous bowel tissue. It aims to understand how these parts of your body might contribute to bowel cancer development and how they could be used to improve future treatments.
France