RecruitingNAINTERVENTIONAL

Clinical and Objective Psychiatric Analyses in Severe Depression.

This study aims to discover new ways to understand and measure severe depression using modern computer technology. If you are an adult patient at Lille University Hospital with severe depression, you might be invited to join. Researchers will use special cameras and sensors during your regular assessment interviews. They'll record things like your facial expressions, how you move, and the sound of your voice. They'll also measure your heart rate, skin temperature, and brain activity using a special bracelet and headset. These measurements help find tiny changes (called 'objective markers') that aren't usually noticed. The goal is to see if these markers can help doctors understand severe depression better and track how patients are getting on, potentially leading to more effective treatments in the future.

At a glance

Status

Recruiting

Phase

Sponsor

University Hospital, Lille

Enrolment target

300

Start

30 Nov 2023

Estimated completion

01 Nov 2027

Depression

What is this study about?

This study is called CALYPSO, and it's trying to find new and better ways to understand severe depression. Doctors know that severe depression can be very tough, and they're always looking for new tools to help diagnose it and track how people are feeling.

The researchers want to use advanced computer technology to spot very small changes in how people with severe depression look, move, and sound. They'll record participants during their regular hospital assessments using special cameras and sensors. This isn't about judging you or your feelings, but rather about collecting precise information. They'll look at things like changes in your facial expressions, the way you move your body, and even details about your voice, such as its tone and loudness. They'll also measure things like your heart rate, how your skin reacts, your body temperature, and even changes in your brain activity. The idea is that these tiny, measurable signs might give doctors extra clues about how severe your depression is and how you're responding to treatment.

By carefully collecting this information over time, both during your hospital stay and after you go home, the study hopes to create a clearer picture of severe depression. This could mean that in the future, doctors might have more objective ways to understand your condition, which could lead to more personalised and effective support and treatments for depression.

Key takeaways

Uses advanced computer tech to understand depression.
Will record your facial expressions, movements, and voice.
No new medicines involved, just observations.
Weekly recordings during hospital, then follow-ups for a year.
Could help doctors understand depression better in the future.
You can stop participating at any time.

Who may be eligible?

To be part of this study, you need to be an adult (18 years or older) with severe depression. You must be currently staying in the adult psychiatry department at Lille University Hospital. You also need to have health insurance and be willing to follow the study's plan.

There are some reasons why you wouldn't be able to join. These include if you decline to take part after hearing all about the study, or if you are pregnant or breastfeeding. You also can't join if you are not free to make your own decisions (for example, if you are under a court order or guardianship). The study needs people who can fully understand and agree to participate on their own behalf.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you currently an inpatient in the adult psychiatry department at Lille University Hospital with severe depression?
Do you have social health insurance?
Are you willing and able to follow the study plan for about a year?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you'll be involved in a few steps. Firstly, during your hospital stay, you'll have an initial visit where doctors will ask about your health and your depression. They will also use a special interview called the Hamilton scale to check how severe your depression is. During this interview, you'll sit in an armchair about 2 to 3 metres from a camera that will record you. This camera, along with a microphone, will capture your facial expressions, movements, and voice. You'll also be offered a special bracelet and headset to wear during this time, which will measure things like your physical activity, heart rate, skin temperature, and brain activity.

These interviews and recordings will happen weekly in a specially equipped room during your hospital stay. After you leave the hospital, there will be follow-up checks at 3 months, 6 months, and 12 months. These follow-up checks will involve repeating the same Hamilton scale interview and recordings of your facial expressions, movements, voice, and other measurements. The study does not involve any new medication; it's all about how these measurements can help understand your depression better. The total time you'd be involved in the study, including follow-up, is about a year after you leave the hospital.

Potential risks and benefits

Taking part in this study may not directly benefit you, as it aims to gather information for future understanding of depression. However, it could help improve how depression is understood and treated for others in the future. The risks are generally low; it involves being recorded during your usual assessments and wearing some sensors, which shouldn't cause discomfort. All your personal data will be kept private. You are completely free to change your mind and withdraw from the study at any time without giving a reason, and this decision will not affect your care in any way.

Locations (1)

Hôpital Fontan 1 - CHU de Lille
Verified postcode
Lille, France· Recruiting

Common questions

What is the main goal of this study?

The main goal is to find new ways, using computer technology, to measure and understand severe depression better.

Will I have to take new medicines?

No, this study does not involve any new medicines. It focuses on recording your expressions, movements, and other body signals.

How long will I be involved in the study?

You'll have recordings during your hospital stay and then follow-up checks at 3, 6, and 12 months after you leave the hospital, so about a year in total.

What kind of measurements will be taken?

They'll record your facial expressions, body movements, voice, heart rate, skin temperature, and brain activity using cameras and special sensors.

Can I stop participating if I want to?

Yes, absolutely. You can withdraw from the study at any time without it affecting your medical care.

How to find out more

Ali AMAD, MD, PhD

ali.amad@chu-lille.fr 3 20 44 44 60 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.