Major Depressive Disorder (MDD) research hub
50 indexed studies · 31 currently recruiting
- recruitingPHASE3
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
This study is looking into a new medication called CYB003 for adults with major depression. It aims to see if CYB003 is safe and effective when added to their current antidepressant treatment, compared to a dummy pill.
United States · Australia · Czechia - recruitingNA
Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.
This study looks at whether a special nutritional drink, 'Think Tank', can help middle-aged women aged 40-60 think more clearly after stressful experiences. Researchers will compare it to a dummy drink to see if it improves memory, attention, and overall well-being.
United Kingdom - recruiting
Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE)
This study looks at how medical cannabis helps people in the UK with pain, sleep problems, anxiety, depression, or epilepsy. We want to see how well it works over time using patient feedback.
Canada - recruitingNA
Mechanisms Underlying Antidepressant Effects of Physical Activity
This study looks at how exercise helps people with depression. We want to understand what goes on in the body and brain when people exercise, to make exercise plans even better. Participants will do either aerobic exercise or stretching for 8 weeks.
United Kingdom - recruitingNA
Internet-delivered Cognitive Behaviour Therapy for Students: Duration Preference Trial
This study looks at online mental health courses for university and college students dealing with depression or anxiety. It compares different course lengths (fast, 5-week, or 8-week options) to see which ones students prefer and find most helpful for managing their feelings.
Canada - recruitingNA
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Inflammation and Depression Following SCI
This study looks at whether a gentle electrical stimulation applied to the ear can help people with spinal cord injury who are also experiencing depression and inflammation. It aims to see if this treatment, called taVNS, can improve their mood and reduce body inflammation.
Canada - recruitingNA
Internet-Delivered Cognitive Behaviour Therapy for Depression and Anxiety in Perinatal Parents
This study looks at an online therapy program for new and expecting parents feeling anxious or down. It checks how well this program, called the Wellbeing Course for New and Expecting Parents, helps parents and if it's easy to use. The program lasts 8 weeks.
Canada - active not recruitingPHASE4
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
This study for adults with bipolar depression compares treatments like Cariprazine and combined Aripiprazole/Escitalopram. It looks at which medicines work best to help people get well and stay well over a year.
United States · Canada - recruitingNA
Effectiveness of Digital Cognitive Behavioral Therapy for Insomnia in Frontline Health Care Workers (The HCW-CBTi Study)
This study looks at a digital program to help healthcare workers, especially those on the front lines during COVID-19, sleep better. It checks if this online therapy can improve their sleep, mental health, and overall well-being.
Canada - active not recruitingNA
CAMH PARTNERs Integrated Care Study
This study looks at a new way to help people with depression, anxiety, or alcohol issues. It uses a special team and phone support to work with your family doctor. We want to see if this helps you feel better and improves your quality of life.
Canada - not yet recruitingNA
Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Recruited in an Outpatient Setting
This five-year study aims to better understand depression by looking at different types of depression and how they might affect people over time. Participants will have blood samples taken to help identify these differences.
Germany - recruitingNA
Ecological Momentary Intervention for Reward in Anhedonia
This study looks at a new way to help people with anhedonia (finding less pleasure in things), anxiety, and depression. It uses a smartphone app over two weeks to teach skills like positive thinking and managing stress.
Germany - recruitingNA
The Taste-Mood Diagnostic Study
This study is investigating if a simple taste test can help diagnose depression and predict how well antidepressants might work. Participants will do taste tests before and after starting a new antidepressant for their depression.
United Kingdom - active not recruitingNA
Virtual Reality to Reduce Pre-procedure Anxiety Prior ECT
This study explores if virtual reality (VR) videos can help reduce anxiety in patients before electroconvulsive therapy (ECT). It compares VR education to standard discussions, measuring anxiety, knowledge, heart rate, and blood pressure to see which method works best.
Canada - recruitingNA
Clinical and Objective Psychiatric Analyses in Severe Depression.
This study looks for new ways to understand severe depression by using clever computer methods. Researchers record videos and other measurements during hospital visits to spot slight changes in facial expressions, movement, and voice. This could lead to better ways to help people with depression.
France - recruiting
Evaluation of the Naturalistic User Experience of the Website "ich Bin Alles @Schule" (i Am Everything @school)
This study looks at how useful and easy to use a German website called "ich bin alles @Schule" is. It's for school staff to learn about depression and mental health in students. The aim is to see if the website helps and reaches the people it's meant for.
Germany - recruitingNA
Nitrous Oxide and EMOtional Cognition
This study investigates how nitrous oxide (like 'laughing gas') affects how healthy people aged 18-40 remember difficult memories and process emotions. Researchers hope to understand if it could help with depression by altering emotional responses.
United Kingdom - recruitingNA
Treating Depression on a Day-to-day Basis: Development of a Tool for Physicians Based on a Smartphone Application
This study is checking if a smartphone app can help doctors better understand and treat depression. It aims to improve how doctors provide care by looking at daily symptoms and how well people take their medication, using a mobile phone tool to gather information.
France - completedPhase 0
Exploring the safety and practicality of strobe light therapy for depression
This study is testing if strobe light therapy, similar to experiences from the 'Dreamachine' art project, can be a safe and practical new way to help people with depression. It's an early-stage study funded by the Medical Research Council.
United Kingdom · England - recruiting
ADepT+ therapy for complex depression
This study looks at a new therapy called ADepT+ for people with depression that’s difficult to treat. It aims to see if this therapy helps people who also struggle with relationships, emotions, or their sense of self. It's a trial to prepare for a larger study.
United Kingdom · England - completedNot Applicable
Assessing the safety, tolerability, and feasibility of a stroboscopic intervention protocol in people with depression
This study is looking at how a special type of light treatment, called stroboscopic stimulation, could help people with depression. It checks if it's safe, easy to use, and if it helps improve mood. Researchers want to find new, gentle ways to treat depression.
United Kingdom · England - active not recruiting
Characterizing MyMood Patterns of Use
This study looks at how people use MyMood, a special online tool for tracking moods, developed at Sunnybrook Health Sciences Centre. We want to see if things like age, sex, or having a mood disorder affect how often and how long people use it. MyMood helps people with conditions like depression and bipolar disorder.
Canada - recruitingNA
Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression
This study looks at a new way to treat depression using brain stimulation. We're comparing standard brain stimulation with a more personalised approach, hoping to improve how well it works for people with depression.
Canada - active not recruitingNA
MST for Parkinson's Disease
This study is testing a new treatment called Magnetic Seizure Therapy (MST) for depression in people with Parkinson's disease. It wants to see if MST is a practical and safe option before it's compared to other treatments in the future. The trial is happening in Canada and involves 20 patients.
Canada - recruitingNA
Emotion Focused Family Therapy for Parents of Children With Mental Health Difficulties
This study looks at a therapy called Emotion Focused Family Therapy (EFFT) for parents. It aims to teach parents skills to help their children aged 7-15 who are struggling with anxiety, depression, or behaviour issues. The hope is to improve how children feel and how families work together.
Canada - recruitingNA
Cognitive Remediation in Forensic Mental Health Care
This study looks at a special kind of mental exercise called 'cognitive remediation' for people in forensic mental health care. It aims to see if these exercises can improve thinking skills, everyday abilities, and mental well-being in patients dealing with conditions like schizophrenia or ADHD.
Canada - recruitingNA
Adaptation and Pilot Testing of Web and Mobile Interface for the ATTACH™ Intervention
This study is adapting a successful parenting programme, ATTACH™, for online delivery. It aims to help parents facing tough situations like depression or addiction to support their children's well-being, especially during times like the COVID-19 pandemic when in-person visits are difficult.
Canada - recruitingNA
Improving Care and Mental Well-Being for Adults With Heart Failure
This study looks at a new way to support people with heart failure by focusing on their mental health. It's called FRAME. The aim is to see if this support can be easily offered in different healthcare settings and to improve well-being for those with heart failure.
Canada - recruitingPHASE2
Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease
This study looks at whether a special good-bacteria supplement (probiotic) can help improve feelings of sadness and depression in people with Parkinson's disease. Participants will take either the probiotic or a dummy pill for 12 weeks to see if it makes a difference.
Canada - recruitingNA
JoyPop Mobile Mental Health App With Youth
This study looks at how a mental health app, JoyPop, can help young people (aged 12-17) who are waiting for mental health services. It aims to see if the app can improve how they manage their feelings while they wait for help.
Canada - recruiting
Biobank and Brain Health in Bordeaux.
This study, called "B cube," looks at how our brains change as we get older, especially from age 55. Researchers want to understand why some people's memories and thinking skills decline and how to prevent it. They are studying 2000 people in Bordeaux, France, focusing on things like diet and overall health.
France - recruitingNA
The Sleep Course: An Online Sleep Intervention for Adults With Self-reported Sleep Difficulties
This study looks at an online course called 'The Sleep Course' for adults in Saskatchewan struggling with difficulties sleeping. It aims to see if this online therapy, which helps with sleep, depression, and anxiety, is effective and easy to use in real-world settings.
Canada - recruitingNA
Auricular Acupuncture in Patients With Advanced Cancer: a Randomized Clinical Trial.
This study is looking at how a type of ear acupuncture, called ear acupressure, might help people with advanced cancer. It aims to see if it can improve how they feel overall, and if it helps with common problems like tiredness, pain, feeling down, and sleep issues.
Germany - recruitingNA
TrueBlue Clinical Study - Investigating the Use of a Mobile Phone App TrueBlue for Monitoring Depression and Anxiety
This study is looking at a mobile phone app called TrueBlue. It aims to see if the app can safely and helpfully monitor feelings of depression and anxiety in pregnant women and new mothers in Nottinghamshire. We want to find out how easy it is to use and if it works well.
United Kingdom - recruiting
Who Fares Best With Mindfulness Meditation
This study looks at how mindfulness meditation affects different people. It aims to find out who benefits most and who might experience problems. Researchers want to understand why mindfulness works for some and not for others, especially those with past trauma or negative thinking.
Belgium · United Kingdom - recruiting
Visual Frailty in Ageing
This study looks at 'visual frailty' in older people with a common eye condition called AMD. Researchers want to understand and measure how vision problems, general health, and mental well-being are linked, to help improve care for ageing eyes.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase I, first-in-man, randomised, placebo-controlled, single dose escalation study to investigate the effects of LPH-5 on safety, tolerability, pharmacokinetic and pharmacodynamic parameters in healthy participants
This study is looking at a new medicine called LPH-5 for depression. It's the first time we're testing it in people to see if it's safe, how much the body absorbs, and what it does. Healthy adults will be involved.
France - authorisedHuman Pharmacology (Phase I)- Other
Unraveling the aesthetic mind in anhedonia, insights from pharmacological imaging of the human brain: A single-blind, randomized, placebo-controlled cross-over study
This study looks at how people with depression experience beauty and art, and how a new treatment might affect these feelings. It’s a very early-stage trial, comparing the treatment to a dummy pill in adults.
Austria - authorisedTherapeutic exploratory (Phase II)
Targeting inflammation in depression using Minocycline: a patient stratification approach using peripheral inflammatory biomarkers and MRI
This study is looking at how a common antibiotic, Minocycline, might help people with depression. Researchers will see if it reduces inflammation in the body and if that helps improve mood. They'll also use brain scans to understand the changes.
Italy - ongoing, recruitingTherapeutic use (Phase IV)
PRECISER; Prediction of ECT treatment response and reduction of Cognitive Side-effects using EEG and Rivastigmine
This study looks at ways to improve depression treatment using ECT (electroconvulsive therapy). Researchers are testing a medication called rivastigmine to see if it can help reduce memory problems from ECT and predict who will respond best to the treatment.
Netherlands - recruitingNot Applicable
Sleep Blinding Psilocybin, a feasibility study: Examining if participants can tell if they received psilocybin or a placebo when medication is given to act in sleep
This study explores a new way to test psilocybin (from 'magic mushrooms') for depression by giving it to people while they sleep. This helps researchers understand how it works without participants knowing if they received the drug or a dummy pill.
United Kingdom · England - recruitingNA
Evaluating the Impact AI Avatar-led Mental Health Interventions for Keeping Employees in Work
This study looks at whether an AI avatar called Remi can help employees with depression symptoms. It's an online program offering short, guided sessions. We want to see if it improves mood and work life, and if people find it helpful and safe.
United Kingdom - recruiting
Gut feeling: probiotics with sertraline in primary care depression
This study looks at combining a probiotic with sertraline, an antidepressant, for people with depression. It wants to see if this combination improves mood and gut health, and if it's practical to use.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A randomized, double-blind, single-center, 2-period cross-over Phase I study to assess the tolerability, safety and pharmacokinetics of antidepressant doses of oral ketamine hydrochloride prolonged release tablets (KET01) compared to intranasal esketamine in healthy male subjects
This study is looking at a new tablet treatment for depression called KET01, comparing it to an existing nasal spray called Spravato. It's an early study to see if KET01 is safe, how the body handles it, and if it causes any unwanted effects in healthy men.
Germany - active not recruitingPHASE1, PHASE2
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
This study is looking at a new drug called ELE-101 for depression. It checks how safe it is and how it works in healthy people first, then in people with depression, to see if it could be a helpful new treatment.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
Etude de phase II évaluant la capacité d'un agoniste des récepteurs 5-HT4, le prucalopride (Resolor©), à accélérer l'efficacité thérapeutique d'un antidépresseur de type ISRS: preuve de concept clinique.
This study looks at whether adding a drug called prucalopride to a common antidepressant (escitalopram) can help people with depression feel better faster. Researchers will compare how well people feel over six weeks when taking either prucalopride or a dummy pill alongside their antidepressant.
France - recruitingNA
StratCare Trial 2: Evaluating the Clinical and Cost-effectiveness of AI-driven Stratified Care for Depression
This study looks at whether an AI tool called ‘StratCare’ can help people with depression get the right treatment faster in the NHS. It compares this new approach to the usual way of offering therapy.
United Kingdom - recruiting
Serotonin effects on brain function and their relationship to relapse when stopping antidepressants
This study looks at why depression sometimes comes back when people stop taking antidepressants. Researchers will study brain activity in people who have recovered from depression and plan to stop their medication. The aim is to understand how changes in brain chemicals contribute to relapse.
United Kingdom · England - recruitingNA
Effectiveness of CAT-GSH for Returning Patients
This study looks at two types of guided self-help therapy for people who have had anxiety or low mood before and are returning to NHS Talking Therapies. It compares CAT-GSH with CBT-GSH to see which works best and is preferred for those coming back for more support.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
OSU6162 as add-on in SSRI/SNRI-resistant depression (ODEN): a double-blind, placebo-controlled evaluation of efficacy and safety
This study is looking into a new treatment called OSU6162 for people with depression that hasn't improved with usual medications like SSRIs or SNRIs. It compares OSU6162 to a dummy pill (placebo) to see if it helps reduce depression symptoms and if it's safe.
Sweden