RecruitingNAINTERVENTIONAL

Platelets Activation in Brain Neoplasms

This study is investigating the role of tiny blood cells called platelets in brain tumours, specifically gliomas. While platelets are mainly known for stopping bleeding, research suggests they might also be involved in how cancers develop and spread. This study aims to understand if platelets are present within brain tumours and whether they influence how a patient's condition progresses. Researchers believe that if platelets are helping the tumour, then targeting them could potentially make anti-cancer drugs work better. This study will look at tumour samples and blood tests to explore these connections and help pave the way for improved treatments.

At a glance

Status

Recruiting

Phase

Sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Enrolment target

Start

27 Oct 2022

Estimated completion

01 Oct 2029

Glioma Blood Platelets Inflammation Brain Neoplasms

What is this study about?

This study is about understanding a type of tiny blood cell called platelets, and how they might be involved in brain tumours, specifically a type known as glioma. You might know platelets for their main job, which is to help your blood clot and stop bleeding. However, scientists are learning that platelets might do much more, especially when it comes to cancer.

Researchers think that platelets might play a part in how tumours grow, spread, and even how well anti-cancer treatments work. For example, some studies suggest platelets could help tumours make new blood vessels, which they need to grow. They might also help cancer cells move to other parts of the body. Another idea is that platelets might help protect the tumour's blood vessels, which could make it harder for anti-cancer drugs to reach and attack the tumour effectively.

The main goal of this study is to see if these platelets are actually present inside brain tumour tissue, and if their presence is linked to how patients with these tumours progress over time. By understanding this better, the hope is to find new ways to improve existing anti-cancer treatments, perhaps by targeting these platelets. This could potentially lead to more effective therapies for people with brain tumours.

Key takeaways

This study explores how blood platelets might affect brain tumours.
It aims to understand if platelets are found inside tumours and their potential role.
No new treatments are given; it's an observational study using existing samples.
Results could help develop better anti-cancer therapies in the future.
Participation involves providing tumour tissue and blood samples already planned for your care.

Who may be eligible?

To be able to take part in this study, you would need to be an adult over 18 years old. You must also be planning to have a brain or spinal cord tumour removed or a biopsy taken. This means a small piece of the tumour will be taken for examination.

It's important that you are happy to give your permission to be part of the study. Also, you must be a member of the social security system, which applies to most people living in the UK.

There are some reasons why you wouldn't be able to join. For example, if the amount of tumour tissue removed isn't enough for all the extra tests the study wants to do. You also can't take part if you are pregnant or breastfeeding, or if you are under certain legal protections.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you scheduled for a brain or spinal cord tumour removal or biopsy?
Are you happy to give your permission to be in the study?
Are you a member of the social security system (e.g., NHS in the UK)?
Are you not pregnant or breastfeeding?

Answer every question to see your result.

What does participation involve?

This is a descriptive study, which means it mainly involves looking at information without giving you any new treatments or medicines. If you are eligible and agree to take part, the main things involved would be allowing the research team to use a small part of the tumour tissue that is already being removed during your planned operation or biopsy. They would also take some blood samples, likely at the same time as your routine blood tests for your hospital care. There are no additional hospital visits or follow-up appointments specifically for this study. The researchers will simply collect and analyse the samples, and then look at your medical information over time to see if there are any links. The total duration for you would involve the consent process and the sample collection at the time of your surgery.

Potential risks and benefits

There are no direct medical benefits to you from taking part in this study, as it's observational and won't involve new treatments. However, your participation will help scientists learn more about brain tumours and potentially contribute to developing better treatments in the future for others. The risks are very low; they mainly involve the usual minor discomfort from having blood taken, and the use of a small part of your tumour sample that would otherwise be discarded or used for other routine tests. You are free to withdraw from the study at any time without giving a reason, and this will not affect your medical care.

Locations (1)

Fondation A De Rothschild
Verified postcode
Paris, France· Recruiting

Common questions

What exactly are platelets?

Platelets are very tiny cells in your blood that are mostly known for helping your blood clot if you cut yourself. They stop bleeding.

Why are researchers interested in platelets for brain tumours?

Scientists are finding that platelets might do more than just clot blood; they could also play a part in how cancers grow, spread, and respond to treatment. This study wants to see if this is true for brain tumours.

Will I receive any new treatment if I join this study?

No, this study is about observing and learning from samples you already provide during your usual medical care. It doesn't involve any new treatments or medicines for you.

What happens to my tumour sample?

A small part of the tumour tissue removed during your planned operation or biopsy will be saved and analysed by the researchers. This won't affect your normal diagnosis.

Will taking part impact my regular medical care?

No, taking part in this study will not affect your regular medical care or the treatments you receive. Your care team will continue to look after you as normal.

How to find out more

Amélie YACHITZ, MD

ayavchitz@for.paris (0)148036454 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.