RecruitingPhase IInterventional

Deferred registration: HMR code: 25-008

This study is a Phase 1 clinical trial designed for healthy human volunteers aged 18 to 55. In Phase 1 studies, researchers test a new medicine or treatment in humans for the first time or in a new way. The main goal is to check safety, look for side effects, and see how the body handles the medicine. The trial registration is currently marked as 'deferred'. This is a normal practice in the UK that allows research teams to protect commercial details for a limited time before releasing full study specifics to the public. Volunteers in this study must be in good general health. If you choose to take part, the trial team will give you a full information sheet explaining the medicine, the schedule of visits, and any potential risks before you decide whether to join.

At a glance

Status

Recruiting

Phase

Phase I

Sponsor

OnTrack Therapeutics Limited (a wholly owned subsidiary of Pangea Botanica Ltd [trading as Pangea Bio])

Enrolment target

136

Start

21 Jul 2026

Estimated completion

31 May 2027

Healthy volunteers

What is this study about?

This clinical trial is a Phase 1 research study. Phase 1 trials are the very first step in testing a new medical treatment in people. Before a medicine can be used to treat patients with a specific illness, scientists must first make sure it is safe to use. They do this by giving small, carefully measured doses to a small group of healthy volunteers.

The title of this study mentions 'deferred registration'. In the UK, research rules allow drug developers to temporarily delay publishing the full chemical and scientific details of an early trial. This is common when developing new medicines to protect commercial patents and ideas. Even though some details are not yet public online, the study has to pass strict medical and safety reviews by UK ethics committees before anyone can take part.

By taking part, healthy volunteers help doctors learn how a drug is absorbed, how it moves through the body, and how long it stays in the system. This information is vital for working out the right dose for future patients.

Studies like this are essential building blocks for modern healthcare. Every medicine currently available at your local pharmacy or hospital had to start with a Phase 1 trial involving healthy volunteers.

Key takeaways

Phase 1 trial focused on safety in healthy volunteers.
Open to men and women aged 18 to 55.
Full details are temporarily deferred under standard UK research guidelines.
Volunteers will receive full information before deciding whether to take part.
Participation usually involves medical tests and close monitoring at a clinic.

Who may be eligible?

This trial is open to healthy adults between the ages of 18 and 55. Both men and women can apply. Because the trial needs to see how the treatment works in a healthy body, you should generally be free of major medical conditions.

While the detailed exclusion list has not been published yet due to the study's deferred status, Phase 1 trials usually exclude people who have long-term health problems (such as heart disease or asthma), those who take regular prescription medications, or people who smoke heavily. Pregnant or breastfeeding women are also typically unable to join.

If you contact the trial unit, their medical staff will run through a detailed health check to see if you qualify before you sign up.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

I am between 18 and 55 years old.
I consider myself to be in good general health.
I do not have a serious or ongoing medical condition.
I am not taking regular prescription medicines.
I am willing to visit a clinical research clinic for monitoring and tests.

Answer every question to see your result.

What does participation involve?

Taking part in a Phase 1 study usually begins with a screening visit where doctors check your blood pressure, test your blood and urine, and take a heart trace (ECG). If you are eligible, you will receive the study treatment, which could be a tablet, liquid, or injection. You may be asked to stay overnight at a specialist clinical research unit for a few days so medical staff can monitor you closely, followed by several short outpatient visits. During these visits, doctors will monitor your vital signs, take blood samples, and ask how you feel. The total time you are involved can range from a few weeks to a couple of months.

Potential risks and benefits

Taking part does not provide direct medical treatment, as you are joining as a healthy volunteer. However, you will receive a thorough medical check-up, and volunteers are often compensated for their time and travel expenses. The risks depend on the medicine being tested, but they can include unexpected side effects, allergic reactions, or minor discomfort from blood tests. Every volunteer is monitored closely by doctors, and you always have the right to leave the study at any time without giving a reason.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Hammersmith Medicines Research
Unverified
London, England

Common questions

What is a Phase 1 trial?

A Phase 1 trial is the earliest phase of human testing. It focuses on checking the safety, side effects, and correct dosage of a new treatment in a small group of people.

What does 'deferred registration' mean?

It means the full scientific details are temporarily kept private to protect commercial information. However, the trial must still meet all strict UK safety and ethical standards.

Will I be paid for taking part?

Phase 1 trials involving healthy volunteers usually offer financial compensation for your time, effort, and travel expenses.

Can I leave the trial if I change my mind?

Yes. Taking part is completely voluntary. You are free to withdraw from the trial at any point, and your future medical care will not be affected.

How is my safety protected?

Phase 1 trials take place in specialist units with doctors and nurses on hand. Doses usually start very low, and your health is checked continuously throughout the study.

How to find out more

Thomas Pfeiffer

info@ontrack.health - Official trial record

Always speak to your GP or specialist before deciding to take part in a study.