Ongoing, recruitingHuman Pharmacology (Phase I)- OtherInterventional

A clinical trial of MK-3214 taken with different liquids in healthy participants (MK-3214-002)

This study, called MK-3214-002, is looking at a new investigational medicine named MK-3214. It involves healthy men and is designed to find out how the body takes in, uses, and gets rid of this medicine when it's swallowed with different liquids. This type of research is an early step in developing new medicines. Although the medicine might eventually help people with high cholesterol, this specific study is focused on healthy volunteers to understand the basic science of how the medicine works in the body. It helps researchers gather important safety and dosage information before it's tested in people with the condition.

At a glance

Status

Ongoing, recruiting

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Merck Sharp & Dohme LLC

Enrolment target

Start

06 Mar 2026

Hypercholesterolaemia

What is this study about?

This study is about a new medicine called MK-3214. Researchers want to learn more about how this medicine behaves in the body. They are specifically interested in how taking it with different drinks might affect it. This is a very early-stage study, sometimes called a Phase I study. This means it's one of the first times the medicine is being given to people.

The main goal is to understand how the body absorbs, distributes, breaks down, and gets rid of MK-3214. This is important foundational information that helps scientists figure out the best way to give the medicine in the future. The study involves healthy volunteers, not people with a specific illness, because it helps researchers focus purely on how the body handles the medicine without other health conditions making it complicated.

While this particular study isn't directly treating a condition, the medicine itself is being developed for hypercholesterolaemia. This is the medical term for high cholesterol. High cholesterol can increase the risk of heart problems, so finding new ways to manage it is important. The information learned from healthy volunteers in studies like this helps pave the way for future studies that might test the medicine in people with high cholesterol, hopefully leading to a new treatment option.

Key takeaways

This is an early study of a new medicine for potential high cholesterol treatment.
It's for healthy men, aged 18 and over.
The study looks at how the medicine works when taken with different drinks.
It helps gather important safety and dosage information.
Participation involves clinic visits, health checks, and taking the medicine.
You would contribute to future medical advancements.

Who may be eligible?

To take part in this study, you must be a healthy man. You need to be at least 18 years old, and there isn't an upper age limit specified, meaning older healthy men can also take part.

The study is only looking for men who are generally healthy. This means you should not have any significant ongoing medical conditions that could interfere with the study medicine or the way your body processes it. Specific details about what 'healthy' means in this study, such as liver or kidney function, would be discussed with the study team.

Since this is an early study, the research team will do careful checks to make sure you are right for the study. This helps keep you safe and ensures the results of the study are reliable.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Am I a man?
Am I 18 years old or older?
Am I generally in good health?
Do I understand that this isn't a treatment for high cholesterol, but a research study?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would be asked to attend several appointments at a research clinic. You would receive doses of the study medicine, MK-3214, likely on different occasions and with different liquids as part of the study design. These visits would include health checks, blood and urine tests, and monitoring to see how your body reacts to the medicine.

There might be overnight stays at the clinic, especially for the periods when you are taking the medicine, so that the research team can closely monitor you. You would also have follow-up visits after you've taken the medicine to make sure you're well and to collect any final information. The full duration of your involvement could range from a few weeks to a couple of months, including screening, dosing periods, and follow-up.

Potential risks and benefits

Taking part in any study has potential benefits and potential risks. A potential benefit could be contributing to medical knowledge that may help develop new treatments for high cholesterol in the future. You would also receive careful health monitoring throughout the study. Potential risks could include side effects from the study medicine, although these studies are designed to be as safe as possible for healthy volunteers. There might also be discomfort from blood tests or other procedures. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Belgium

Common questions

What is MK-3214?

MK-3214 is a new investigational medicine that is being studied for its potential to help with high cholesterol. This study is an early step in understanding how it works.

Why are healthy people taking part if it's for high cholesterol?

Studies with healthy volunteers help researchers understand how a new medicine works in the body without other health conditions affecting the results. This is an important early step before it's tested in people with high cholesterol.

Will I get paid to take part?

Many early-stage studies offer payment for your time and inconvenience. The study team will be able to provide details on any compensation if you qualify.

What does 'Phase I' mean?

'Phase I' means this is one of the very first times a new medicine is being tested in humans. These studies focus on safety and how the body handles the medicine.

How long will I need to be involved?

The total time you'll be involved, including screening, taking the medicine, and follow-up, will be explained by the study team. It typically ranges from a few weeks to a couple of months.