- completed
Text messaging and training to support the taking of statins
This UK study tests whether text message reminders help people take their cholesterol-lowering statins regularly. It also offers extra training for GP surgery staff. Researchers want to see if this combination helps patients keep their cholesterol at safer levels and lowers their risk of heart disease and strokes.
United Kingdom · England - authorisedTherapeutic confirmatory (Phase III)
A Phase III Randomised, Double-Blind, Factorial Design Study to Assess the Effect of Fixed Dose Combination Laroprovstat/Rosuvastatin compared with Laroprovstat, Rosuvastatin, and Placebo on Low-Density Lipoprotein Cholesterol in Lipid-Lowering Treatment-Naïve Patients
This clinical trial looks at a new combination tablet for adults with high cholesterol who have never taken cholesterol medication before. Researchers want to see if combining two drugs (laroprovstat and rosuvastatin) lowers "bad" cholesterol better over eight weeks than taking either medicine alone or a dummy pill (placebo).
Germany · Bulgaria · Hungary - recruitingHuman Pharmacology (Phase I)- First administration to humans
A clinical study of MK-3214 in healthy people (MK-3214-001)
This study is testing a new medicine, MK-3214, for people with high cholesterol. We want to see how safe it is and how it works in healthy men. It's an early-stage study to understand the medicine better.
Belgium - recruitingHuman Pharmacology (Phase I)- Other
A clinical trial of MK-3214 taken with different liquids in healthy participants (MK-3214-002)
This study is testing a new medicine called MK-3214 in healthy men. It wants to see how the medicine works when taken with different drinks. The goal is to understand how the body handles this medicine, which might help people with high cholesterol in the future.
Belgium - active not recruitingPHASE3
Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes
This study looks at a new daily pill, enlicitide decanoate, for people at high risk of heart problems like heart attacks or strokes. It aims to see if this pill can help reduce these serious events safely, compared to a dummy pill.
United States · Argentina · Australia - recruiting
Does synbiotic supplementation improve the effects of a ketogenic diet?
This study looks at whether a supplement called a synbiotic can help reduce "bad" cholesterol increases when people follow a ketogenic diet. We want to see if it helps keep gut bacteria healthy and prevents cholesterol from going too high, making ketogenic diets safer.
United Kingdom · England - recruitingPHASE1
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
This study is testing a new medicine called CTX310 for people in the UK with high cholesterol and fats in their blood that haven't improved with usual treatments. It will check if the medicine is safe and how well people tolerate different doses. It's an early-stage study.
United States · Australia · New Zealand - recruitingPHASE3
A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin and Placebo on LDL-C in LLT-naïve Patients.
This study is looking at a new combination medicine (laroprovstat/rosuvastatin) for people with high cholesterol who haven't taken cholesterol-lowering medicines before. It wants to see if this new combination is safe and effective at lowering 'bad' cholesterol (LDL-C) compared to its individual ingredients or a dummy pill.
United States · Bulgaria · Canada - recruitingPHASE3
Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 Days
This study compares two cholesterol-lowering medicines, obicetrapib and bempedoic acid, in adults with high cholesterol or mixed dyslipidemia. It looks at how well they reduce 'bad' cholesterol (LDL-C) and if they are safe, especially for people at higher risk of heart problems.
United Kingdom