A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)

To join this study, you need to be an adult between 18 and 75 years old and have been diagnosed with Irritable Bowel Syndrome with Constipation (IBS-C) according to specific medical guidelines (called Rome IV criteria). This means your condition should include regular constipation (how doctors describe stools based on their shape) and also experience tummy pain that is at least a moderate level on most days.

There are also some reasons why you might not be able to take part. For example, if your IBS mainly involves diarrhoea, or if it's a mix of both constipation and diarrhoea, this study might not be suitable. Also, if you have other gut conditions like inflammatory bowel disease (Crohn's or Ulcerative Colitis) or problems with how food moves through your stomach, you wouldn't be able to join.

The study team will carefully check your medical history and current health to make sure you meet all the criteria and that it's safe for you to participate.

If you decide to take part, the study will last about 35 weeks, which is roughly eight months. Throughout this time, you will have regular visits to the clinic where the study team will monitor your health and how you’re feeling. You'll receive the study medicine (either brenipatide or a placebo) as an injection just under your skin.

You'll be asked to keep a daily electronic diary (eDiary) to record your symptoms, such as tummy pain and bowel movements. This helps the team understand how the medicine is affecting you day-to-day. There will also be appointments where the team will take measurements, ask about your general health, and check for any side effects.