CAD-EYE System for the Detection of Neoplastic Lesions in Patients With Lynch Syndrome
This study is investigating a new computer-assisted system called CAD EYE, which uses artificial intelligence (AI), to screen for bowel growths in people with Lynch Syndrome. Lynch Syndrome is a genetic condition that significantly increases a person's risk of developing bowel cancer, often at a younger age. Currently, a special type of colonoscopy called chromoendoscopy is recommended in some places, but it can be time-consuming. CAD EYE is designed to help doctors detect polyps (small growths that can turn into cancer) in real-time during a colonoscopy. This research aims to compare the effectiveness of the CAD EYE system with the current recommended method to see if it's just as good at finding these growths, potentially offering a simpler way to screen for bowel cancer in people with Lynch Syndrome.
At a glance
What is this study about?
Lynch Syndrome is a condition that runs in families and increases your chance of getting certain cancers, especially bowel cancer. Because of this, regular check-ups using a colonoscopy are really important to find any growths (called polyps) early, before they might become cancerous. Finding and removing these polyps can help prevent bowel cancer or catch it when it's most treatable.
Currently, one of the best ways to do these colonoscopies involves using a special dye called indigo carmine chromoendoscopy (often shortened to CE). This dye helps doctors see polyps more clearly. However, this method can take a bit more time and requires specific training, so it's not always used everywhere.
This study wants to see if a new technology called CAD EYE, which uses artificial intelligence (AI), can be just as good at finding these growths. CAD EYE acts like a second pair of eyes, helping the doctor spot polyps in real-time during your colonoscopy. AI systems like CAD EYE have shown promise in other studies for helping doctors find more polyps. This research is important because it's the first time we're looking at how well CAD EYE works specifically for people with Lynch Syndrome, potentially offering a more widely available and efficient way to screen for bowel cancer.
Key takeaways
- The study tests an AI system (CAD EYE) for finding bowel growths.
- It's for people with Lynch Syndrome, who have a higher risk of bowel cancer.
- CAD EYE aims to help doctors detect polyps during routine colonoscopies.
- The study compares CAD EYE to the current standard screening method.
- Participation involves a standard colonoscopy procedure.
- The goal is to see if this new AI tool is as effective as existing methods in this high-risk group.
Who may be eligible?
To join this study, you need to have a confirmed diagnosis of Lynch Syndrome, meaning you have a specific genetic change linked to the condition. You'll also need to be an adult of legal age and give your clear agreement to take part. You must be covered by a social security system and understand French or be able to read French as well.
There are some reasons why you might not be able to join. For example, if you've had major bowel surgery like a total colectomy, or if you have inflammatory bowel conditions like Crohn's disease or ulcerative colitis. Also, if you're allergic to certain medications used for bowel preparation before a colonoscopy, or if your bowel isn't prepared well enough for the procedure, you wouldn't be able to participate.
Pregnant women, people who are under guardianship, or those who aren't covered by a social security system cannot be part of this study. The study wants to include both men and women between the ages of 18 and 90.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Do I have a confirmed diagnosis of Lynch Syndrome?
- Am I 18 years old or older?
- Do I understand and agree to participate in the study?
- Am I covered by a social security plan?
- Can I understand and read French?
- Have I had a total colectomy or do I have inflammatory bowel disease?
What does participation involve?
If you decide to take part in this study, you would undergo a colonoscopy as part of your regular screening for Lynch Syndrome. During the procedure, the doctors would use the CAD EYE system. This system is designed to help them detect polyps on the spot. You would then be compared to people who have their colonoscopy using the standard chromoendoscopy method. The study aims to see if the AI system is as effective as the current standard. There isn't any extra medication involved beyond what's normally used for a colonoscopy and the standard bowel preparation. The total duration of your involvement in the study would primarily be centered around the single colonoscopy procedure itself.
Potential risks and benefits
Locations (1)
- Hôpital Européen Georges-Pompidou HEGPVerified postcodeParis, France· Recruiting
Common questions
What is Lynch Syndrome?
Lynch Syndrome is a condition that runs in families and increases your risk of certain cancers, especially bowel cancer.
What is a colonoscopy?
A colonoscopy is a procedure where a doctor uses a thin, flexible tube with a camera to look inside your large bowel for any growths or changes.
What is CAD EYE?
CAD EYE is an artificial intelligence (AI) system that helps doctors spot polyps (small growths) more easily during a colonoscopy.
Why is this study important for people with Lynch Syndrome?
This study aims to find out if the CAD EYE system can improve how we screen for bowel cancer in people with Lynch Syndrome, potentially making procedures more effective.
Will I have to pay to be part of the study?
No, if you’re part of a social security system, the study itself shouldn't cost you money. The standard colonoscopy costs would be covered as usual.
How to find out more
Guillaume Perrod, MD
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
Community discussion
Powered by our forum at community.patient.info. Please be respectful — this is not medical advice.