- completed
Quality of life after surgery and other options to prevent cancer of the lining of the womb (endometrial cancer)
This UK study looks at the quality of life of women with Lynch syndrome who consider or have surgery to remove their womb to prevent cancer. By filling out a short 15-minute survey, participants help researchers understand who might benefit most from preventive surgery in the future.
United Kingdom · England - authorisedPhase I and Phase II (Integrated)- First administration to humans
Preventive Dendritic Cell vaccination for Lynch Syndrome (PREVENT-Lynch)
This early-stage study is testing a new preventive vaccine for adults with Lynch syndrome. Lynch syndrome is an inherited genetic condition that increases the risk of certain cancers. The vaccine aims to train the body's immune system to recognise and destroy abnormal cells before cancer has a chance to develop.
Netherlands - completedNot Applicable
Finding the best dose of aspirin to prevent Lynch Syndrome cancers
This UK study looks at whether lower daily doses of aspirin can prevent cancer in people with Lynch syndrome just as well as higher doses. Lynch syndrome is an inherited condition that raises cancer risk. Researchers hope lower doses will offer strong protection with fewer stomach-related side effects.
United Kingdom · England - not yet recruiting
Protocol for Non-invasive Gynaecological Surveillance in Lynch Syndrome
This study is looking for easier ways to check for womb cancer in people with Lynch syndrome. Instead of uncomfortable hospital tests, researchers are trying simple urine and self-collected swab tests. They want to see if these new tests can find cancer early and be more comfortable for patients.
United Kingdom - recruitingNA
CAD-EYE System for the Detection of Neoplastic Lesions in Patients With Lynch Syndrome
This study looks at a new AI system called CAD EYE to help doctors find bowel growths in people with Lynch Syndrome during colonoscopies. This condition increases the risk of bowel cancer. The goal is to see if CAD EYE works as well as current methods to detect these growths early.
France - recruitingNA
Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)
This study looks for early signs of bladder and kidney cancers in people with Lynch syndrome. We're testing a new urine test to see if it can find these cancers sooner than current methods, helping people get treatment earlier.
Canada · Finland - recruitingNA
Video Capsule Examination in Patients With Lynch Syndrome
This study is testing if a tiny camera in a capsule can help doctors check for bowel cancer in people with certain inherited conditions. Researchers want to create computer programs to make it easier for doctors to review these images, potentially speeding up testing for more people.
United Kingdom - recruitingNA
Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire
This study looks at whether women with Lynch syndrome can use a simple home test to check for early signs of womb cancer. It also asks if they find this self-testing easy and helpful. The goal is to find better ways to spot cancer risk sooner.
Canada - recruiting
Small Bowel Capsule Endoscopy in Lynch Syndrome
This study looks back at records of people with Lynch syndrome who had a small bowel capsule endoscopy. It aims to understand how well this test finds early changes or cancers in the small bowel and how it helped with their care.
France - not yet recruitingNA
Study Aiming to Test Whether Non-invasive Liquid Biopsies Can Safely Reduce Invasive Surveillance Methods in Lynch Syndrome
This study looks at new, gentler ways to check for cancer in people with Lynch syndrome. Instead of usual colonoscopies, we're testing urine, blood, and stool samples to see if they can safely help reduce the number of invasive checks needed.
Croatia · Czechia · Finland - recruiting
PSYLIVED: the Psychological Impacts of Living With an Inherited Colorectal Cancer Predisposition Syndrome
This study, PSYLIVED, explores the emotional journey of people in the UK living with or at risk of inherited bowel cancer. It aims to understand how they cope, helping to improve support services and care tailored to their needs.
United Kingdom