A Study on Ubiquinol on Fatigue and Muscle Strength in Healthy Adults Taking GLP-1 Agonists

To be part of this study, you need to be an adult aged between 30 and 65 years old. You should have a body mass index (BMI) that falls within a certain range (between 27 and 35). Crucially, you must be either just starting or have recently started (within the last four weeks) taking a specific weight-loss medication prescribed by a doctor, such as Wegovy (semaglutide 2.4mg) or Mounjaro (tirzepatide).

You'll also need to be able to move around physically, for example, be able to do five sit-to-stand movements. Because this is a remote study, you'll need a smartphone that can download the study app (iPhone iOS 15.6 or newer, or Android 9 or newer) and your own digital weighing scales. You should be able to speak and read English well enough to understand the study materials, and you must be willing to give your full agreement to take part.

There are also some reasons why you wouldn't be able to join. For example, if you've already used ubiquinol or CoQ10 in the last three months, or if you have certain health conditions like type 1 or 2 diabetes, heart disease, or severe liver disease, as these might affect tiredness independently. You also can't take part if you've used statin medication before, have previously used GLP-1 weight-loss medicines (other than your current prescribed one), or have had weight-loss surgery. The study isn't suitable if you are pregnant, breastfeeding, or planning to become pregnant during the study, or if you plan to stop your weight-loss medication within the nine-month study period.

If you join this study, you will take either one ubiquinol capsule (100 mg) or one placebo capsule (a dummy pill with no active ingredient) every day for nine months. You won't know which one you are taking.

A nurse will visit your home four times during the study (at the beginning, then after 3, 6, and 9 months). During these visits, the nurse will take a small blood sample, measure your body (like your weight and height), and watch you do a simple exercise test where you stand up and sit down a few times.

You will also have a short video call each month with a study dietitian, which will last about 20-30 minutes. Every three months, you'll need to complete some questionnaires and record what you eat for four days using a special smartphone app. You'll also log any exercise you do in the same app throughout the study. This study is completely remote, so you won't need to travel to a clinic or hospital at any point.