Obesity and overweight research hub
19 indexed studies · 16 currently recruiting
- authorisedPhase I and Phase II (Integrated)- First administration to humans
A study assessing the safety, tolerability, pharmacokinetics and efficacy of single and multiple doses of NNC0638-0355 in participants with overweight or obesity
This clinical trial is testing a new experimental medicine called NNC0638-0355 for adults living with overweight or obesity. Doctors want to see how safe the medicine is, how it moves through the body, and whether it helps people lose weight over 26 to 32 weeks compared to a dummy drug.
Netherlands - recruitingNA
A Study on Ubiquinol on Fatigue and Muscle Strength in Healthy Adults Taking GLP-1 Agonists
This study looks at whether a daily ubiquinol supplement can help healthy adults taking weight-loss medication (like Wegovy or Mounjaro) feel less tired and keep their muscles strong. Ubiquinol is a natural substance that helps your body produce energy.
United Kingdom - active not recruitingNA
Childhood Obesity Management Using Innovative Digital Technology
This study looks at a 10-week online program called the Family Healthy Living Program (FHLP) for families with children aged 8-12 who are at risk of being overweight. It compares this program to simply providing online healthy living materials to see which works better.
Canada - recruiting
Visceral Adipose Tissue and Liver Changes Associated With Semaglutide in CKD
This study looks at how a drug called semaglutide affects body fat and the liver in people with type 2 diabetes and kidney disease. It aims to understand how this medication helps improve health by looking closely at fat tissue.
Canada - recruiting
How Metabolism Affects Weight Loss and Gain
This study looks at why some people struggle to lose weight and others find it hard to gain weight. Researchers will measure how the body uses energy after fasting and after a special meal to understand different ways our bodies handle calories. This could lead to better weight management plans.
Germany - active not recruitingPHASE3
Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
This study looks at a new weekly injection, MET097, for adults who are overweight or have obesity. It checks how well it helps with weight loss and if it's safe. The study lasts for 84 weeks, focusing on participants without type 2 diabetes.
United States · Bulgaria · Canada - not yet recruitingNA
Empowering Healthy Lifestyle Personalised Intervention to Prevent and Control Obesity: The HealthyW8 Project
The HealthyW8 study explores a digital tool to help different age groups, from children to older adults, make healthier lifestyle choices. It aims to prevent and manage obesity by offering personalised advice on diet, exercise, and sleep through apps and devices.
Bulgaria · Denmark · Germany - not yet recruitingNA
Effects of HIIT Following PTR Programme
This study looks at whether a home-based exercise program (HIIT) can help people who have put their Type 2 diabetes into remission to stay diabetes-free for longer. It compares this special exercise with usual care after completing the NHS Path to Remission program.
United Kingdom - not yet recruitingNA
SENSILINS: Impact of Cephalic Phase Insulin Release Induced by an Environmental Food Odor Stimulus on Glucose Homeostasis According to Insulin Sensitivity Level
This study looks at whether smelling pleasant food before eating affects how your body handles sugar. It's for adults with or without obesity and insulin resistance, to see if smell can improve blood sugar control.
France - not yet recruitingNA
Shift Workers' Health Behavior Action Program Across Europe
This study looks at how a healthy living programme can help night-shift workers sleep better, improve their health, and manage their weight. We want to see if it helps them get more sleep each night.
Germany · Netherlands · Poland - enrolling by invitationNA
Real-world Exploration of Digital iNnovation in the Management of Excess Weight
This study looks at a new digital programme to help people in South East London manage their weight. It checks if this online approach improves health, saves money, and makes weight management services better for everyone, especially those with obesity.
United Kingdom - not yet recruitingNA
Postprandial Thermogenesis in Obese Adolescents: Effect of Weight Loss
This study looks into how the body burns calories after eating, especially in teenagers who are overweight or obese. It wants to see if losing weight changes how their bodies use energy from food, to better understand how to tackle childhood obesity.
France - recruiting
Global Overweight and oBesE (GLOBE) Patient Registry, Development and Implementation of Disease-specific: Severity, Quality of Life and Cost Instruments.
This study aims to better understand how being overweight or obese affects people's lives in the UK. We want to develop tools to measure how severe it is, impact on quality of life, and the associated costs, helping to improve support for patients.
United Kingdom - recruitingNA
Function and Lean Mass Preservation With Resistance Exercise During a GLP-1RA Treatment
This study looks at how exercise can help women on a new weight loss drug called tirzepatide keep their muscle mass and stay strong. We know tirzepatide helps with weight loss, but it can also reduce muscle. This research hopes to find a way to prevent that.
United Kingdom - not yet recruitingNA
Incretin-based Therapies, Nutrition, and Physical Activity
This study looks at whether combining a new weight-loss medication with six months of healthy eating and exercise helps people with obesity keep their muscles strong. We also want to see if working with local fitness centres is helpful.
Canada - recruitingNA
Intermittent Carbohydrate Restriction in Cardiometabolic Health
This study looks at how cutting down carbohydrates in your diet, either on certain days or at certain times, affects weight and health in adults who are overweight. It hopes to find new ways to help people manage their health.
United Kingdom - recruitingNA
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults
This study looks at how a new weight loss medicine, Tirzepatide, affects high blood pressure in young adults who are overweight or obese. We want to see if losing weight can help lower blood pressure more effectively than usual care.
United Kingdom - recruitingNA
The Causal Role of Ketone Bodies in Obesity-associated Disease Prevention - Combining Genetic Epidemiology With a Randomised Trial to Infer Causality
This study looks into how special body chemicals called ketones, which come from certain diets, might help prevent diseases linked to being overweight. Researchers want to see if ketone supplements can offer these benefits without the drawbacks of strict diets.
United Kingdom - recruitingNA
Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis
This study looks at how weight loss (using a medication called tirzepatide) or treatment with iksekizumab affects people with psoriatic arthritis who are also overweight or obese. It checks changes in their skin, joints, and fat.
United Kingdom