RecruitingNAINTERVENTIONAL

Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery

This study focuses on people with obesity who are having weight-loss surgery. The main aim is to understand how a type of medicine called a GLP-1 agonist affects body fat. These medicines are often used to help with weight management. Researchers are particularly interested in whether these medicines change the levels of a hormone called oxytocin in the body. By looking at people who take GLP-1 medicines compared to those who don't, the study hopes to find out more about how these treatments work on body fat. This information could be important for developing new ways to help people manage their weight and prevent health problems linked to obesity.

At a glance

Status

Recruiting

Phase

Sponsor

Centre Hospitalier Universitaire de Nice

Enrolment target

Start

06 Mar 2024

Estimated completion

06 Mar 2027

Obesity

What is this study about?

This study is looking into how certain medicines, known as GLP-1 agonists, affect body fat in people who are having weight-loss surgery. Obesity can lead to many health issues, and understanding how different treatments work on body fat is really important for improving health. GLP-1 agonists are a type of medicine that can help with weight management, and researchers want to find out more about their specific effects.

The main goal is to see if people who take a GLP-1 agonist have different levels of a hormone called oxytocin compared to those who don't. Oxytocin is known for various roles in the body, and changes in its levels might give clues about how GLP-1 medicines influence body fat. By studying this, the researchers hope to gain a better understanding of the science behind these treatments.

Ultimately, this research aims to provide valuable insights into how GLP-1 agonists work at a deeper level. This knowledge could help doctors and patients make more informed decisions about weight management strategies in the future, and potentially lead to even better ways to help people maintain a healthy weight and prevent related health problems like metabolic syndrome.

Key takeaways

This study investigates how GLP-1 medicines affect body fat in people having weight-loss surgery.
Researchers are specifically looking at changes in oxytocin hormone levels.
The goal is to better understand how these weight-loss treatments work.
It involves people already taking GLP-1 medicines and those who are not.
Participation requires being over 18 and approved for weight-loss surgery.

Who may be eligible?

To join this study, you need to be over 18 years old and be able to understand the study information. You must have obesity, which means having a Body Mass Index (BMI) of over 35 with at least one related health problem, or a BMI over 40 on its own. You also need to have been approved for weight-loss surgery by a team of specialists.

If you've been taking a GLP-1 agonist medicine, you would need to have been on it for at least three months. If you haven't taken a GLP-1 agonist, that's also fine, as the study is comparing these two groups. You also need to be part of a social security scheme and give your written permission to take part.

However, you cannot join if you are pregnant or breastfeeding, if you are under special protection like guardianship, or if you are in prison. This is to ensure the safety and well-being of all participants.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you over 18 years old?
Do you have a BMI over 35 with a health condition, or a BMI over 40?
Have you been approved for weight-loss surgery by your medical team?
Are you able to understand written information and give your consent?
Are you NOT pregnant or breastfeeding?

Answer every question to see your result.

What does participation involve?

The detailed steps for taking part in this particular study, including the number of visits, specific tests like blood samples, and how long you would be followed, are not provided in this summary. However, generally, in studies like this, you would likely have some initial assessments and then further checks sometime after your weight-loss surgery. You would be assigned to either the group taking a GLP-1 agonist (if you already are) or the group not taking one. The study aims to look at how these different situations affect your body. All procedures would be fully explained to you before you agree to participate, and you would be able to ask any questions.

Potential risks and benefits

Participating in research studies like this can help advance medical knowledge, potentially leading to better treatments for obesity in the future. You wouldn't receive direct medical benefits from simply participating in the study itself beyond your usual care. There are usually minimal risks involved in studies like this, mainly from blood tests, such as slight bruising or discomfort. All study procedures would be carefully explained, and your safety is a top priority. Remember that taking part is entirely voluntary, and you have the right to withdraw from the study at any time without affecting your medical care.

Locations (1)

CHU de Nice - Hôpital de l'Archet
Verified postcode
Nice, France· Recruiting

Common questions

What is a GLP-1 agonist?

It's a type of medicine often used to help people with obesity manage their weight and blood sugar levels.

What is oxytocin?

Oxytocin is a hormone in your body that has various roles, and researchers are exploring if it's linked to how weight-loss medicines work on body fat.

Will I have to take new medicines as part of this study?

The study compares people who already take GLP-1 medicines with those who don't. You wouldn't be asked to start a new medicine just for the study itself.

What kind of tests will I have?

The information provided suggests blood tests to measure GLP-1 and oxytocin levels, but all specific tests would be fully explained if you join.

How long will the study last for me?

The summary doesn't give a specific duration, but typically studies involve initial checks and follow-up appointments after surgery.

How to find out more

ROUX Christian, PhD

roux.c@chu-nice.fr +3349209220 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.