- active not recruitingPHASE2
A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight
This study is testing a new medicine, BI 3034701, to see if it helps adults with obesity or overweight lose weight. Participants will get either the medicine or dummy medicine, plus advice on diet and exercise.
United States · Australia · Canada - recruitingTherapeutic confirmatory (Phase III)
Multicentre, randomised, double-blind, placebo-controlled, 48-week, Phase III trial to evaluate the efficacy and safety of survodutide administered subcutaneously in participants with overweight or obesity and presumed or confirmed nonalcoholic steatohepatitis (NASH)
This study is testing a new injection called survodutide for people who are overweight or living with obesity and have an inflamed, fatty liver. Researchers want to see if the medicine can safely reduce liver fat by at least 30% and help people lose weight over 48 weeks.
Germany · Spain · Netherlands - recruitingTherapeutic use (Phase IV)
The effect of liraglutide on MMC activity, gastrointestinal hormones, hunger ratings and ad libitum food intake in healthy volunteers.
This study looks at how a medicine called liraglutide affects the digestive system in healthy adults. Researchers want to see how it changes gut movements, hunger signals, blood sugar, and the amount of food people choose to eat compared to a simple dummy saltwater injection.
Belgium - active not recruitingPHASE3
Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes
This study is looking at a new medicine called Ribupatide for people living with obesity. It compares Ribupatide with another medicine, Semaglutide, and a dummy treatment, to see how well it helps with weight loss. We want to find out if Ribupatide is more effective and safe.
United States · Australia · Bulgaria - authorisedPhase I and Phase II (Integrated)- Other
A two-part, randomised, double-blind, placebo-controlled, parallel-group, 12week trial investigating the safety, tolerability, pharmacokinetics and efficacy of XEN-D0501 in obese participants
This 12-week study tests a new medicine called XEN-D0501 for adults living with obesity. Researchers want to check if the treatment is safe, well-tolerated, and whether it can help people lose weight, reduce body fat, and improve blood sugar levels compared to a dummy pill.
Sweden - recruitingHuman Pharmacology (Phase I)- Other
Defining the Glucagon Unit: Investigating the Impact on Energy Expenditure and Glucose Level Deviation in healthy volunteers
This study for healthy men aged 18 and over investigates how different substances, including medicines for weight loss and hormones, affect the body's energy use and blood sugar levels. Researchers want to understand these effects to help treat conditions like obesity.
Latvia - recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c. 1.0 mg/1.0 mg and 1.7 mg/1.7 mg) once-weekly in participants with overweight or obesity
This study is looking at a new combination medicine, CagriSema, for adults who are overweight or have obesity. It wants to see if this weekly injection helps people lose weight and if it's safe to use. Researchers hope it can lead to meaningful weight loss.
France · Germany - recruitingTherapeutic use (Phase IV)
Young adults with early-onset obesity treated with semaglutide -The RESETTLE study - a randomized double blind placebo-controlled clinical trial
This study, called RESETTLE, is looking at how a medicine called semaglutide helps young adults with obesity. It compares semaglutide to a dummy medicine to see if it makes a difference to their weight and overall health.
Denmark - recruitingHuman Pharmacology (Phase I)- First administration to humans
A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE ASCENDING DOSE PHASE 1 STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETIC, AND PHARMACODYNAMIC PROFILE OF RES-010 IN HEALTHY, OVERWEIGHT, AND MODERATELY OBESE SUBJECTS
This study is testing a new medicine, RES-010, for obesity in healthy, overweight, and moderately obese adults. It's an early-stage study to check its safety, how well bodies handle it, and its effects, compared to a dummy pill.
Netherlands - recruitingTherapeutic exploratory (Phase II)
A PilOt dose-escalation trial with EMP16 in preparation for Phase III – the POEM trial
This study is looking at a new way to help people with obesity manage their weight. It compares a new treatment called EMP16 with a common weight-loss medicine, Orlistat, to see how they affect tummy troubles.
Sweden - recruitingPHASE3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
This study is looking into a new medication called Eloralintide for people who are overweight or have obesity but don't have type 2 diabetes. It aims to see how well it works and if it's safe to help with weight management.
United States · Argentina · Australia - recruitingPHASE3
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
This study is for children and teenagers aged 6-17 who are overweight or have obesity. It's testing a new medication called Orforglipron to see if it's safe and helps with weight management, compared to a dummy medicine. It aims to find better ways to help young people manage their weight.
United States · Belgium · Brazil - recruitingPHASE3
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
This study looks at a new medicine, NNC0487-0111, for people with heart failure and obesity. It compares the medicine to a dummy treatment (placebo) to see if it's safe and helps improve heart health.
United States · Argentina · Australia - not yet recruitingPHASE3
A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity
This study is testing a new medicine called Zenagamtide for people who have heart and blood vessel problems (like previous heart attack or stroke) and are also overweight or obese. It wants to see if Zenagamtide is safe and helps these patients better than a dummy medicine.
United States · Argentina · Australia - recruitingPHASE3
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
This study looks at a medicine called tirzepatide for teenagers aged 12-17 who are overweight and have related health problems. Researchers want to see if it helps with weight and heart health when combined with healthy eating and exercise.
United States · Argentina · Australia - recruitingPHASE3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study looks at a new medicine, Maridebart cafraglutide, for people with heart failure and obesity. It aims to see if the medicine can reduce heart-related problems like hospital stays, improve symptoms, and help people live longer, alongside their usual heart failure care.
United States · Argentina · Australia - active not recruitingPHASE3
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
This study is looking at how a medication called Tirzepatide might help people living with obesity. Researchers want to see if it can reduce serious health problems and improve overall health in adults.
United States · Argentina · Australia - not yet recruitingPHASE3
A Study of EloraTZP in Adult Participants With Obesity Without Type 2 Diabetes
This study is looking into a new combination treatment called EloraTZP for adults living with obesity. It compares EloraTZP with other existing treatments and a dummy treatment (placebo) to see how safe and effective it is for helping people lose weight. It's for people without type 2 diabetes.
United States · Argentina · China - completedPhase I
Testing the safety and effects of a new study drug (GCG-06) in adult subjects (GCG-06 - first doses in human)
This early-stage clinical trial tests a new medicine called GCG-06 for the very first time in humans. Researchers want to see if it is safe and well tolerated. GCG-06 acts like a natural body hormone that reduces appetite. The study involves healthy adults staying overnight in a specialist clinic.
United Kingdom · England - completed
Game of Stones: Helping men to lose weight
Game of Stones is a UK research study testing whether text messages and cash rewards can help men lose weight and keep it off. Designed by men, for men, it is open to adult men in Glasgow, Belfast, and Bristol who want to find practical ways to improve their health.
United Kingdom · England · Northern Ireland - completedPhase II
Can restricting the blood supply to part of the stomach lead to weight loss in severely overweight patients?
This UK study tests whether blocking some blood flow to the top of the stomach helps people with severe weight problems lose weight. Doctors use a thin tube to block tiny blood vessels, which may lower hunger hormones. Half the participants receive the treatment, and half receive a pretend procedure.
United Kingdom · England - recruitingTherapeutic exploratory (Phase II)
Dapiglutide for the treatment of obesity (DREAM): a randomised, double-blind, placebo-controlled, investigator-initiated trial
This study, called DREAM, is looking into a new medication called dapiglutide for treating obesity. It's in an early stage (Phase II) and aims to see how much dapiglutide can help people lose weight, compared to a dummy pill. Researchers will also check its effects on gut health and inflammation.
Denmark - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Control Of BioEquivalence with Xenical (COBEX): A Phase I, randomized, active-control study to evaluate EMP22 pharmacodynamics and EMP16 pharmacokinetics versus Xenical® in healthy volunteers.
This study is comparing two new medicines (EMP22 and EMP16) for obesity with an existing one (Xenical). We want to see how much fat is passed in your poo when taking these medicines. It's a first step to understand how they work in healthy adults.
Sweden - recruitingHuman Pharmacology (Phase I)- Other
A study of how CagriSema works on appetite in people with excess body weight
This study is looking at how a new drug called CagriSema affects appetite in people who are overweight or have obesity. It's an early-stage study to understand how this medication works in the body.
Germany - recruitingHuman Pharmacology (Phase I)- Other
A research study to look at how CagriSema influences food intake, appetite and emptying of the stomach in people with excess body weight
This study is looking at a new medicine called CagriSema to see how it affects eating, hunger, and how quickly your stomach empties if you are overweight. It's an early study to understand how it works in the body.
Germany - recruitingTherapeutic confirmatory (Phase III)
I8F-MC-GPHJ: A Phase 3b, Randomized Controlled Study to Evaluate the Efficacy and Safety of Tirzepatide Compared to Semaglutide 2.4 mg in Adults Who Have Obesity or Overweight with Weight-Related Comorbidities
This study is comparing two medicines, Tirzepatide and Semaglutide, to see which is more effective and safer for helping adults with obesity or overweight, who also have other health issues, to lose weight. It's looking at how much weight people lose and other health changes.
Germany · Belgium · Poland - recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity without type 2 diabetes
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity. It wants to see if the medicine helps with weight loss and if it's safe. Participants will get either the real medicine or a dummy injection.
Germany · Netherlands · Sweden - recruiting
Support for weight loss for adults from the dental team when attending routine appointments at dental practices
This study looks at whether dental teams can help adults with weight management. If you join, your height and weight will be measured at your dental check-up, and you'll discuss healthy habits with your dental team to see if this helps improve health.
United Kingdom - recruitingHuman Pharmacology (Phase I)- Other
A study in people with overweight or obesity to test how BI 1820237, BI 456906, or a combination of both affects brain activity
This study is looking at two new potential medicines to help people who are overweight or have obesity. It aims to understand how these medicines, used alone or together, might affect brain activity. This could help us learn more about how our brains control weight.
Germany - not yet recruitingPHASE3
ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease
This study looks at a new medicine called survodutide for people who are overweight or obese and have a type of fatty liver disease. Researchers want to see if this medicine can help improve the health and function of their heart. Participants receive weekly injections, either the medicine or a dummy injection.
United States · China · Germany - active not recruitingPHASE3
Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
This study is looking at a new medicine called KAI-9531. It aims to see if weekly injections of this medicine can help people who are overweight or obese, and have other health issues related to their weight, lose weight. We want to know if it's safe and effective.
United States · Argentina · Australia - not yet recruitingNA
Glycaemic Response of Arabic Bread
This study is looking at how different types of Arabic bread, made with chickpea, pea, or lentil flour, affect blood sugar levels. They want to see if these breads can help keep blood sugar more steady compared to regular wheat bread in people who are overweight or have obesity.
United Kingdom - not yet recruitingNA
The Effect of Time-Restricted Eating in 24-hour Metabolic Homeostasis and Diurnal Rhythm
This study looks at how eating all your meals within a 9-hour window each day affects health markers in people who are overweight or have prediabetes. It hopes to understand if this way of eating can improve how the body uses energy and maintains daily rhythms, without changing total calories.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
The effect of semaglutide therapy on hepatic fat content and on the acute reponse of liver fat to high-fat load in obese MASLD patients
This study looks at how a medicine called semaglutide affects fat in the liver of men with obesity and a condition called MASLD. We want to see if it reduces liver fat and how the liver responds to fatty foods after taking the medicine.
Czechia - recruitingNA
Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and Complex Obesity: the LightBAR Randomised Trial
This study compares an intensive diet and lifestyle programme with weight-loss surgery for adults with severe obesity. We want to see which method works best and is safest, to help improve future treatment options.
Denmark · United Kingdom - recruitingPHASE4
Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability
This study looks at whether a medicine called metformin can help adults with learning disabilities who've gained weight from antipsychotic medicines. These medicines are important, but weight gain can lead to other health problems.
Canada - active not recruiting
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
This study looks at lots of past research to see if swapping animal protein for plant protein makes a difference to health conditions like diabetes, heart problems, and kidney issues. They want to understand if eating more plant-based protein, like from beans or nuts, can be better for our health.
Canada - recruitingPHASE3
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
This study looks at a new medicine, NNC0487-0111, for people who are overweight and have knee pain from arthritis. It wants to see if this medicine helps with losing weight and reducing pain compared to a dummy medicine.
United States · Australia · Bulgaria - recruitingPHASE3
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
This study is testing a new medicine, Maridebart Cafraglutide, for adults with sleep apnea who use a CPAP machine and are also overweight or have obesity. We want to see if the medicine helps improve their sleep apnea and is safe to use over 52 weeks.
United States · Australia · Brazil - recruitingEARLY_PHASE1
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
This study looks at whether apple cider vinegar can increase beneficial gut bacteria in men with prostate cancer starting hormone therapy. Researchers want to see if this helps reduce side effects like weight gain and diabetes, which can be linked to their treatment.
Canada - active not recruiting
Impact of a Regional Program Agir Sur Sa SantE
This study looks at a new care plan called 'Agir Sur Sa SantÉ' (meaning 'Act on Your Health') in our local area. It aims to see how well this plan works for people with conditions like diabetes, obesity, and high blood pressure, focusing on improving their overall health.
Canada - recruitingPHASE3
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
This study looks at a new medicine called retatrutide for people who are overweight or have obesity and suffer from long-term lower back pain. It aims to see if the medicine helps ease their pain and if it's safe to use.
United States · Argentina · Canada - active not recruitingPHASE1
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity
This study looks at a new drug, RO7204239, for people with type 2 diabetes who are overweight or have obesity. It aims to see if the drug can improve how the body uses insulin and affects muscle health. This is an early stage study.
Germany - not yet recruitingNA
Multicentric Approval Study Trans-Duodenal Barrier for Typ 2 Diabetes With Obesity
This study checks a new internal device, the Trans-Duodenal Barrier, for safety and effectiveness in adults with type 2 diabetes and obesity. It's a temporary implant to see if it helps lower blood sugar and reduce weight.
Germany - not yet recruitingNA
Financial Incentives and Weight Loss in Failed Bariatric Surgery
This study looks at whether financial rewards can help people who have regained weight after weight-loss surgery. It explores if a reward system encourages people to achieve and maintain their weight loss goals, and if it's a good way for the health service to help in the future.
France - recruiting
Deep Phenotyping of Peripheral Blood Cells and Circulating Factors in Metabolic Diseases
This study looks at blood cells and other substances in people with obesity, diabetes, and fatty liver disease. Researchers want to understand how these differ in people with and without these conditions to learn more about how they develop.
Germany - recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - recruitingNA
Exercise Training on Brain Insulin Responsiveness
This study looks at how different types of exercise affect brain's response to insulin in people with and without obesity. Researchers compare moderate exercise, intense interval exercise, and no exercise to see which might be best for brain health. It's about understanding how exercise impacts brain signals related to insulin.
Germany - active not recruitingPHASE3
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
This study is looking into a new medicine, NNC0487-0111, to help people who have lost weight keep it off. Participants will get either the new medicine or a dummy medicine by injection once a week to see if it's safe and effective for weight management.
United States · Argentina · Australia - active not recruitingPHASE1
A Study in Healthy People or Otherwise Healthy With Overweight or Obesity to Compare 2 Formulations of Survodutide Given in Different Ways, Either as a Pre-filled Syringe or a Pen-like Injector
This study looks at a new medicine called survodutide for people who are healthy or have overweight/obesity. We want to see if two different versions of the medicine, given with different types of injectors, work similarly in the body. It's an early-stage study.
Germany