- recruitingNA
The Effect of Time-Restricted Eating in Cardiometabolic Health
This study looks at how eating only within a 9-hour window affects health in people who are overweight and have prediabetes. We want to see if this eating pattern can improve important health markers related to heart and metabolic health, without changing body weight.
United Kingdom - active not recruitingPHASE3
A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
This study is investigating a new medication called Retatrutide for people living with obesity. It aims to see how well this medication helps people maintain their weight loss over a long period.
United States · Canada · United Kingdom - recruitingPHASE3
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Researchers are studying a new drug called Maridebart Cafraglutide to see if it can help people with heart disease and who are overweight or obese. The goal is to find out if this drug can lower the risk of heart attacks, strokes, and other serious heart problems.
United States · Argentina · Australia - active not recruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - authorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living with Obesity or Overweight and Diabetes
This study is looking into a new treatment called KAI-9531 for people who are overweight or have obesity and also have diabetes. Researchers want to see if this new medicine can help people lose weight and improve their blood sugar over about a year and a half.
Hungary · Poland · Bulgaria - recruitingNA
The Effect of Obesity and Weight Loss in Heart Failure With Preserved Ejection Fraction
This study investigates if losing weight can help people with a specific type of heart failure called HFpEF. It aims to see if diet-led weight loss improves heart function, exercise ability, and quality of life in overweight or obese patients.
United Kingdom - active not recruitingNA
Impact of an Integrated Obesity Management System on Patient's Care
This study looks at how a special training program for doctors and nurses might help people with obesity. It aims to see if better-trained healthcare teams can help patients manage their weight and related health problems like high blood pressure and type 2 diabetes more effectively.
Canada - recruitingPHASE1
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
This study is looking into a new medication called AZD1043 for people who are overweight or have obesity. Researchers want to understand if it's safe, how the body handles it, and how it affects the body.
United States · United Kingdom - recruitingNA
Intragastric Balloon in Obese Patients With Uncontrolled Asthma
This study looks at how an intragastric balloon, plus diet and exercise, helps people with obesity and uncontrolled asthma. We want to see if it improves asthma control compared to just diet and exercise.
France - not yet recruiting
Endoscopic Sleeve Gastroplasty (ESG) Prospective Trial for Obesity (EGO-Trial)
This study, called EGO-Trial, is looking into a new, less invasive treatment called Endoscopic Sleeve Gastroplasty (ESG) for people living with obesity in France. It aims to see how well it works and how safe it is in real-life healthcare settings.
France · Guadeloupe - enrolling by invitationNA
Cities for Better Health Childhood Obesity Prevention Initiative
This project aims to help children aged 6-13 in several cities globally live healthier lives by preventing childhood obesity. It looks at how community programs in schools and neighbourhoods can improve healthy eating, physical activity, and overall well-being.
Australia · Brazil · Canada - active not recruitingNA
Fit-for-Fertility Multicenter Randomized Controlled Trial
This study looks into how a healthy lifestyle program, called Fit-for-Fertility, can help women with obesity and infertility. It compares this program to standard fertility treatments to see if it improves chances of pregnancy and having a healthy baby.
Canada - active not recruitingPHASE3
A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
This study is looking into a new medication called retatrutide for people living with obesity and heart problems. We want to see if it's safe and helps with weight loss when taken once a week, compared to a dummy medicine.
United States · Argentina · Australia - recruitingPHASE3
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
This study looks at new and existing medicines (CagriSema and Semaglutide) to help people with obesity, sometimes with type 2 diabetes, lose weight. Researchers want to see how safe and effective these medicines are. It lasts about 83 weeks.
United States · Argentina · Australia - not yet recruitingPHASE1
A Study to Evaluate ALN-6222 in Participants With Obesity
This study is looking into a new medication called ALN-6222 for adults who are overweight. It's a first step to see if it's safe, how the body uses it, and if it could help with weight management.
Canada - active not recruitingPHASE3
Semaglutide 2.4 mg in Patients With Poor Weight-loss
This study is looking at whether a medicine called semaglutide, given as a 3mg injection, can help people who haven't lost enough weight after weight-loss surgery. It compares semaglutide to a dummy treatment over 68 weeks to see if it helps with weight loss and overall health.
United Kingdom - recruitingNA
Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery
This study looks at the best way to manage heart bypass surgery for people who are overweight. It's testing if using your lean body weight, rather than total weight, helps decide the right amount of medication and machine settings, making the surgery safer and more effective.
Canada - active not recruitingPHASE3
A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity
This study is looking at a new medicine called CagriSema to help people with obesity lose weight. It compares CagriSema to a dummy medicine over three years. Participants won't know if they're getting the active medicine or the dummy medicine. The aim is to see how well it works long-term.
United States · Belgium · Canada - active not recruitingPHASE3
Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
This study looks at a new medicine called cagrilintide for people with overweight or obesity and type 2 diabetes. It aims to see how well cagrilintide helps people lose weight. Participants will receive either the new medicine or a dummy medicine.
United States · Argentina · Canada - authorisedTherapeutic use (Phase IV)
A neuropsychobiological approach to optimize patient selection for GLP-1-based pharmacotherapy for weight management across the binge eating spectrum
This study looks at how a weight loss injection, Wegovy, affects people with obesity, especially those who also experience binge eating. Researchers want to see changes in weight and binge eating habits after six months of treatment. It's investigating if certain body and brain signals can help pick the best candidates for this treatment.
Belgium - recruitingPHASE3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
This study is looking into a new medication called Eloralintide for people who are overweight or have obesity but don't have type 2 diabetes. It aims to see how well it works and if it's safe to help with weight management.
United States · Argentina · Australia - recruitingNA
Gut Hormones and Roux en Y Gastric Bypass
This study looks at how weight-loss surgery (gastric bypass) changes natural body chemicals called 'gut hormones'. We want to see if these changes help people with obesity and type 2 diabetes by burning more energy, eating less, losing weight, and changing how they react to food.
United Kingdom - recruitingNA
Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery
This study looks at how a medicine called GLP-1 (used for weight loss) affects body fat in people having weight-loss surgery. Researchers want to see if GLP-1 changes levels of a hormone called oxytocin, which might help understand how these treatments work.
France - recruitingPHASE3
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
This study is looking at a new once-a-day tablet, orforglipron, for teenagers (12-17 years old) with obesity or who are overweight with other health issues. It will check if the medicine helps with weight and if it's safe to use.
United States · Israel · Italy - recruitingNA
Endoscopic Sutured Gastroplasty with Endomina® Device Versus Standard of Care in Patients with Type 2 Diabetes and Class I Obesity: a Multi-center, Randomized Controlled Trial
This study looks at a new stomach-reduction procedure for people with type 2 diabetes and obesity. It compares this procedure, called endoscopic gastroplasty using the Endomina device, with standard care to see if it helps put diabetes into remission.
France - enrolling by invitation
The Feasibility of Electrical Impedance Tomography to Guide Non-invasive Respiratory Interventions in Chronic Respiratory Disease
This study explores how a new technology called Electrical Impedance Tomography (EIT) can help doctors set up breathing machines better. EIT gives real-time pictures of the lungs, aiming to make these machines more effective and comfortable for people with serious breathing problems.
United Kingdom - active not recruitingPHASE1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
This study is looking at how two different forms of a new medicine, survodutide, are taken up by the body in healthy people who are overweight or have obesity. It aims to see if both forms work in a similar way.
United Kingdom - recruitingPHASE4
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
This study looks at a new medicine called tirzepatide for adults with obesity but not diabetes. It compares it to standard care to see how well it helps with weight loss and if it can prevent type 2 diabetes over about five years.
United Kingdom - active not recruitingNA
A Behavioural Weight Loss Intervention Delivered in Cardiac Rehabilitation for Patients With Atrial Fibrillation and Obesity
This study looks at how adding weight loss classes to heart rehabilitation helps people with atrial fibrillation (an irregular heartbeat) and obesity. It compares whether combined treatment helps more with losing weight and improving heart rhythm than heart rehabilitation alone.
Canada - active not recruitingPHASE2
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
This study is looking into a new medicine called tirzepatide. It aims to see if tirzepatide can help people with kidney disease who are also overweight or living with obesity, whether or not they have type 2 diabetes.
United States · Austria · Canada - recruitingNA
Comorbid Obesity and Depression With an Anti-inflammatory Medication
This study looks into using a medicine called minocycline for people who have both obesity and depression. It's for those with signs of body inflammation. The aim is to see if this treatment can help improve depression symptoms by reducing inflammation.
United Kingdom - recruitingPHASE1
A Research Study Looking at How NNC0487-0111 Affects Food Intake, Appetite and Metabolism After Meals in People With Obesity
This study looks at how a new medicine, NNC0487-0111, affects how much people with obesity eat, their appetite, and how their bodies use food after meals. Participants will get either the new medicine or a dummy injection, given once a week under the skin.
Germany - active not recruitingPHASE3
A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
This study is looking at two medicines, Retatrutide and Tirzepatide, to see how well and safely they help adults with obesity lose weight. It's comparing them to understand which might be better for weight management.
United States · Argentina · Germany - not yet recruiting
Obesity Medicine Bank of the Quebec Heart and Lung Institute - Laval University (IUCPQ-ULaval)
This study looks at obesity and related health conditions. Researchers are collecting important information and blood samples from patients at a clinic in Quebec, Canada. The goal is to understand how obesity affects health and to find better ways to prevent and treat it.
Canada - recruiting
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism
This study looks at how weight-loss surgery affects blood sugar control and how the body uses energy in people with obesity and type 2 diabetes. We want to understand how this surgery improves health, especially for the liver.
Germany - recruiting
Prevalence, Determinants and Consequences of Dyspnea During Weaning in Critically Ill Obese Patients
This study looks at breathlessness in critically ill patients, particularly those who are overweight, when they're trying to come off a breathing machine. We want to understand how often it happens, why, and what impact it has.
France - recruitingNA
Nutritional Oleic Acid Modulation of adIpose Cholesterol Metabolism in Patients Living With Obesity
This study looks at how a special sunflower oil, rich in oleic acid, might help people living with obesity. It aims to see if this oil can improve how their bodies handle fat and cholesterol, which could lead to better health.
France - recruiting
Evaluation of Possible Postoperative Complications After Nissen Sleeve Gastrectomy. French Multicenter Study
This study compares a new stomach-reduction surgery (Nissen Sleeve) with the standard one for obesity. It looks at whether the new method helps reduce common problems like acid reflux after surgery, which can be a big issue for patients.
France - recruiting
A Biological Atlas of Severe Obesity (Biological Tissue Collection)
This study aims to understand how our genes and lifestyle choices contribute to severe obesity and type 2 diabetes. Researchers will collect tiny tissue samples during planned surgery to learn more about how these complex health conditions develop in different people.
France - recruitingPHASE1, PHASE2
A Study to Evaluate ALN-2232 in Participants With Obesity
This study is looking at a new medicine called ALN-2232 for people living with obesity. It will check if the medicine is safe, how well it's tolerated, and if it helps with weight loss, both by itself and when taken with another medicine called tirzepatide.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study of how CagriSema works on appetite in people with excess body weight
This study is looking at how a new drug called CagriSema affects appetite in people who are overweight or have obesity. It's an early-stage study to understand how this medication works in the body.
Germany - recruitingPHASE3
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
This study is for children and teenagers aged 6-17 who are overweight or have obesity. It's testing a new medication called Orforglipron to see if it's safe and helps with weight management, compared to a dummy medicine. It aims to find better ways to help young people manage their weight.
United States · Belgium · Brazil - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity without type 2 diabetes
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity. It wants to see if the medicine helps with weight loss and if it's safe. Participants will get either the real medicine or a dummy injection.
Germany · Netherlands · Sweden - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study in people with overweight or obesity to test how BI 1820237, BI 456906, or a combination of both affects brain activity
This study is looking at two new potential medicines to help people who are overweight or have obesity. It aims to understand how these medicines, used alone or together, might affect brain activity. This could help us learn more about how our brains control weight.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c. 1.0 mg/1.0 mg and 1.7 mg/1.7 mg) once-weekly in participants with overweight or obesity
This study is looking at a new combination medicine, CagriSema, for adults who are overweight or have obesity. It wants to see if this weekly injection helps people lose weight and if it's safe to use. Researchers hope it can lead to meaningful weight loss.
France · Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Defining the Glucagon Unit: Investigating the Impact on Energy Expenditure and Glucose Level Deviation in healthy volunteers
This study for healthy men aged 18 and over investigates how different substances, including medicines for weight loss and hormones, affect the body's energy use and blood sugar levels. Researchers want to understand these effects to help treat conditions like obesity.
Latvia - authorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Active- and Placebo-Controlled, Partially-Blinded Study to Compare the Efficacy and Safety of KAI-9531 Administered Once Weekly Versus Semaglutide and Placebo in Participants Living with Obesity Who Do Not Have Diabetes
This study is looking at a new medicine, KAI-9531, to help people living with obesity who don't have diabetes. It compares KAI-9531 with an existing medicine (Wegovy) and a dummy treatment to see how well it helps with weight loss and if it's safe.
Poland · Bulgaria - recruitingNA
The Effect of Exercise in Patients Awaiting Bariatric Surgery
This study looks at how a 4-week online exercise programme helps people preparing for weight-loss surgery. It aims to see if exercise before surgery can improve fitness and how the body uses energy, compared to not exercising.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE ASCENDING DOSE PHASE 1 STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETIC, AND PHARMACODYNAMIC PROFILE OF RES-010 IN HEALTHY, OVERWEIGHT, AND MODERATELY OBESE SUBJECTS
This study is testing a new medicine, RES-010, for obesity in healthy, overweight, and moderately obese adults. It's an early-stage study to check its safety, how well bodies handle it, and its effects, compared to a dummy pill.
Netherlands - recruiting
Periodontal Assessment of a Bariatric Care Population
This study looks at gum health in people considering weight-loss surgery. It explores the link between obesity, gum disease, and genetic factors, and examines bacteria in the mouth to understand these connections better.
United Kingdom