ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease

To be considered for this study, you must be at least 18 years old. You should have a Body Mass Index (BMI) of 27 or higher, which is a measure that helps show if you are a healthy weight for your height. Importantly, you must also have been diagnosed with a type of fatty liver disease called metabolic dysfunction-associated steatotic liver disease (MASLD), which would have been confirmed through scans like an ultrasound or a liver biopsy.

There are also reasons why you might not be able to join. For example, if you've recently used other medicines for obesity within the last three months, or if you have a known allergy to the study medicine. People with a current diagnosis of heart failure or severely reduced kidney function are also not able to take part. The study team will review all your health information carefully to ensure it's safe for you to participate.

If you join this study, you will be in it for up to 1.5 years. You will be randomly put into one of two groups: one group will receive the study medicine, survodutide, and the other will receive a 'dummy' injection (placebo) which looks the same but contains no medicine. Neither you nor your study doctor will know which injection you are getting, to keep the results fair.

Both survodutide and the placebo are given as an injection under the skin of your tummy once a week. Your first injection will be given at the study clinic. After that, you'll usually give yourself the injections at home using a pre-filled syringe.

During the study, you'll visit the study clinic about 14 times and have about 4 phone calls with the study team. At some of your visits, doctors will use special ultrasound scans to check your heart's health. The study team will also regularly check your general health and note any changes or health problems you might experience.