A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

This study is looking for adults aged 18 and over who have ongoing lower back pain that mostly affects their lower spine. Your pain should be mainly in your lower back or spread slightly to your upper legs. You also need to have a body mass index (BMI) of 27 or higher, which indicates you are overweight or have obesity. You should also have tried to lose weight through diet at least once before without success.

There are some reasons why you might not be able to join. For example, if your back pain isn't clearly from your lower spine, or if you've had certain injections into your spine (like Botox or steroids within the last year, or trigger point injections within six months). If your weight has changed by more than 5 kilograms (11 pounds) in the last 90 days, or if you've used medicines for weight loss recently, you would also not be able to take part. The study also cannot include people who have had weight-loss surgery or have any type of diabetes.

If you decide to take part, your involvement in the study will last for roughly 80 weeks, which is about a year and a half. During this time, you'll have several visits to the study clinic for assessments. These will likely include check-ups, questionnaires about your pain and overall health, and possibly blood tests. You will be given either the study medicine (retatrutide) or a placebo, and you'll need to take it as instructed. There will be regular follow-up appointments to monitor your progress and make sure you're doing well. The healthcare team will explain all the details of what each visit involves and how often you'll need to attend.