Berlin-Brandenburg Pregnancy Cohort
This study, called the Berlin-Brandenburg Pregnancy Cohort, is investigating common pregnancy problems like pre-eclampsia, high blood pressure, and diabetes. Researchers want to understand how different types of immune cells (our body's defence system) and cells from the placenta (the organ that nourishes the baby) interact. They believe these interactions might play a key role in developing these conditions, especially pre-eclampsia, which can affect a mother's blood vessels and heart. By studying these cells, they hope to learn more about how these complications develop and potentially find ways to predict or manage them better. The study is open to pregnant women aged 18 to 45 years.
At a glance
What is this study about?
This research is all about understanding why some women experience certain health problems during pregnancy. Specifically, it's looking into conditions like pre-eclampsia, which involves high blood pressure and other issues, and diabetes that can develop during pregnancy. We know these conditions can be serious for both mum and baby, and this study aims to get a clearer picture of what causes them.
The researchers think that special cells from our immune system (which fight off infections) and cells from the placenta (the organ that connects the baby to the mum) might be involved. They want to see how these cells work together, or sometimes don't work well together, which could lead to complications. For instance, in pre-eclampsia, they believe certain immune cells might stop blood vessels from working properly, potentially harming the mother's heart and circulatory system.
The main goal is to find out why these conditions happen and how they affect the mother's body. By gathering detailed information about these cellular interactions, the hope is to eventually improve how we predict, prevent, and treat complications of pregnancy, making it safer for more mums and babies.
Key takeaways
- This study explores why some women get pregnancy complications like pre-eclampsia or diabetes.
- Researchers are looking at how immune cells and placenta cells interact.
- It aims to understand effects on the mother's heart and blood vessels.
- Open to pregnant women aged 18-45, including those with these conditions.
- Participation could help improve future care for pregnant women.
- You can withdraw from the study at any time.
Who may be eligible?
This study is looking for pregnant women between the ages of 18 and 45. They welcome women who are generally healthy, as well as those who have been diagnosed with conditions like pre-eclampsia, high blood pressure during pregnancy, or diabetes that started while pregnant.
However, there are some reasons why you might not be able to join. If you have any current infections, or if you have long-term (chronic) health conditions that are already known, you wouldn't be able to take part. Also, if you use alcohol or drugs, this study wouldn't be suitable for you.
To make sure this study is right for you, and that you understand what's involved, you would first have a chat with the study team. If you decide to go ahead, you'd need to give your informed consent, which means you agree to participate after learning all the details.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you a pregnant woman?
- Are you between 18 and 45 years old?
- Do you have a diagnosis of pre-eclampsia, gestational hypertension (high blood pressure in pregnancy), or gestational diabetes?
- Do you *not* have any active infections or serious long-term health conditions?
- Do you *not* use alcohol or drugs?
What does participation involve?
The study description does not provide details on what taking part involves regarding visits, assessments, medication, or follow-up. It focuses more on who can join rather than the specifics of the participation plan. If you are interested, you would need to ask the study team for more information on the time commitment and what procedures are involved, such as blood tests or clinic appointments.
Potential risks and benefits
Locations (1)
- Experimental and Clinical Research Center (ECRC)Verified postcodeBerlin, Germany· Recruiting
Common questions
What is pre-eclampsia?
Pre-eclampsia is a serious pregnancy complication that causes high blood pressure and can affect organs like the kidneys and liver. It usually starts after 20 weeks of pregnancy.
What is gestational diabetes?
Gestational diabetes is a type of diabetes that develops during pregnancy in women who didn't have diabetes before. It can usually be managed with diet and exercise, but sometimes medication is needed.
Will taking part in this study benefit me directly?
This study is mainly for research to help future pregnant women. It's unlikely to directly change your own care, but the information found could be very valuable for others.
Who is running this study?
The study is called the Berlin-Brandenburg Pregnancy Cohort, suggesting it's being conducted by researchers from that region, likely universities or hospitals.
What does 'immune cells' mean?
Immune cells are special cells in our body, like tiny soldiers, that help fight off infections and protect us from illness.
How to find out more
Florian Herse, PhD
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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