Validation of the Snouda Metabolic Score for Phenotyping and Guiding Reversal in Type 2 Diabetes
Most people with Type 2 Diabetes receive the same standard treatment — regardless of what is actually driving their condition. But Type 2 Diabetes is not one disease. It is a collection of different metabolic problems that can look identical on the surface but require very different solutions. This study tests a new clinical tool called the Snouda Metabolic Score (SMS) — a five-pillar assessment system that identifies the specific biological drivers behind each patient’s diabetes. Based on your unique combination of drivers, you receive a personalized 24-week programme targeting the root causes of your condition — not just the symptoms. The study is conducted entirely online. There are no clinic visits required. Participants complete blood tests at a local laboratory of their choice at the start and end of the study, and track their progress through a dedicated digital platform. The primary goal is to measure whether this personalized approach produces a greater reduction in HbA1c — and in some cases, full diabetes remission — compared to standard care.
At a glance
What is this study about?
Imagine your Type 2 Diabetes is like a puzzle, and for each person, the pieces that caused it to develop might be a bit different. Traditionally, treatments often focus on managing the symptoms, like high blood sugar, without necessarily understanding all the underlying reasons why it's happening in your body. This study introduces an exciting new approach.
Researchers are using a special tool called the Snouda Metabolic Score (SMS). This score helps doctors figure out the specific 'patterns' or 'types' of problems in your body that are contributing to your Type 2 Diabetes. For example, it might identify if your body is struggling with how it uses insulin, if you have ongoing inflammation, problems with certain hormones, an imbalance in your gut bacteria, or issues with how your body's cells produce energy. Once your specific pattern is identified, the study will provide you with a personalised plan.
This plan is designed just for you and includes things like dietary changes, a structured exercise routine, and tailored nutritional supplements. For some, there's also an option for carefully managed intermittent fasting. The study wants to see if these personalised approaches lead to better results, such as lower blood sugar levels, or even if people can put their Type 2 Diabetes into remission – meaning their blood sugar levels are healthy without needing to take diabetes medication. This study is particularly interesting because it's done entirely online, meaning you don't need to visit a clinic.
Key takeaways
- This study uses a new method to personalise Type 2 Diabetes treatment.
- It aims to identify individual metabolic issues and create tailored plans.
- The study is completely online; no clinic visits are required.
- Participation involves following a personalised plan for 24 weeks and tracking blood sugars.
- The goal is to see if personalised plans lead to better outcomes, including possible diabetes remission.
Who may be eligible?
To be part of this study, you need to be an adult aged 18 or older and have a confirmed diagnosis of Type 2 Diabetes. Your current HbA1c (a measure of your average blood sugar) should be between 6.5% and 11.0%. You can be taking certain oral diabetes medications like metformin, SGLT2 inhibitors, DPP-4 inhibitors, or sulfonylureas, or managing your diabetes with just lifestyle changes.
It's important that you can use an online platform, are willing to check your blood sugar every day, and can arrange and pay for two specific blood tests (one at the beginning and one at the end of the study). You also need to be able to understand and sign a consent form.
You cannot join if you have Type 1 Diabetes, are pregnant or breastfeeding, or currently use insulin or certain other diabetes medications (GLP-1 receptor agonists). If your HbA1c is very high (over 11.0%), or if you've had severe low blood sugar requiring help from someone else in the past year, you also won't be able to participate. Other reasons for not being able to join include certain serious health problems like active cancer, severe kidney or liver issues, or an active eating disorder.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Do you have a confirmed Type 2 Diabetes diagnosis?
- Is your current HbA1c between 6.5% and 11.0%?
- Are you NOT pregnant or breastfeeding?
- Are you able to use an online platform?
- Are you willing and able to pay for two blood tests?
What does participation involve?
If you join this study, it will last for 24 weeks (about 6 months). You won't need to visit any clinics because the study is conducted completely online through a special digital platform. You'll begin by undergoing an assessment that helps determine your individual metabolic profile – kind of like getting a detailed picture of how your body is handling your diabetes. Based on this, you'll receive a a personalised plan for diet, exercise, and nutritional supplements. There's also an optional part of the plan involving intermittent fasting, if it's suitable for you.
Throughout the study, you'll be asked to check your blood glucose daily and record it. You'll also need to arrange for two specific blood tests: one at the start of the study and another at the end (week 24). You will be responsible for the cost of these tests. All instructions and guidance will be provided through the online platform. You will follow your personalised plan for 24 weeks, after which your final blood test results will be reviewed.
Potential risks and benefits
Locations (1)
- Snouda Health Coaching LtdVerified postcodeManchester, United Kingdom
Common questions
What is the Snouda Metabolic Score?
It's a new tool that helps doctors understand the specific reasons behind a person's Type 2 Diabetes, so treatment can be more personal.
Will I need to visit a hospital or clinic?
No, this study is done entirely online, so you won't need any in-person clinic visits.
Do I have to pay for anything?
Yes, you will need to pay for two specific blood tests (one at the start and one at the end of the study).
What happens if my Type 2 Diabetes gets better?
The study aims to see if personalised plans can help people improve their diabetes or even achieve remission, meaning healthy blood sugar levels without medication.
Can I continue my current diabetes medication during the study?
You can continue certain oral diabetes medications, but not insulin or specific GLP-1 receptor agonists.
What is the Snouda Metabolic Score?From the study team
The Snouda Metabolic Score (SMS) is a clinical assessment tool that evaluates five biological pillars known to drive Type 2 Diabetes: insulin resistance, beta-cell function, inflammatory load, gut-liver axis health, and neuroendocrine (hormonal) regulation. By measuring specific blood markers for each pillar, the SMS identifies which combination of drivers is active in your individual case. This combination — your phenotype — determines your personalized treatment plan. The SMS is the subject of a peer-reviewed scientific publication currently under review at Frontiers in Endocrinology
Will I need to visit a hospital or clinic? From the study team
No. The entire study is conducted online through a dedicated digital platform. The only in-person requirement is arranging two standard blood tests at a laboratory of your choice — the same kind of blood test your GP might order. You do not need a referral; you can book these independently.
Do I have to pay for anything?From the study team
Participation in the study is free. The only costs are the two blood tests (baseline and final), which participants arrange and pay for themselves. The cost of these tests varies by country and laboratory, but is typically equivalent to a standard private blood panel. There are no other fees.
What happens if my Type 2 Diabetes improves significantly during the study? From the study team
This is the goal. If your blood sugar levels normalise during the 24 weeks, this will be recorded as a positive outcome. You should not reduce or stop any prescribed diabetes medication without consulting your own doctor — even if your readings improve. The research team will advise you on how to communicate your progress to your GP or specialist.
Can I continue my current diabetes medication during the study?From the study team
Yes. Participants taking metformin, SGLT-2 inhibitors, DPP-4 inhibitors, or sulfonylureas are eligible and should continue their medication as prescribed throughout the study. Medication changes are a decision for you and your own doctor — not the research team.
How is this different from other diabetes reversal programmes? From the study team
Most reversal programmes apply the same approach to all patients — typically a low-calorie or low- carbohydrate diet. This study is different because it first identifies why your diabetes developed, then designs a plan specifically for that cause. A patient whose diabetes is driven primarily by chronic inflammation will receive a different protocol than a patient whose primary driver is insulin resistance — even though both have the same HbA1c. This precision approach is what the Snouda Metabolic Score makes possible.
Is this study safe?From the study team
Yes. The study has been reviewed and approved by an independent Institutional Review Board (IRB) through WCG, one of the world’s leading independent ethics review organisations. All interventions — dietary, exercise, and supplementation — are evidence-based and non-invasive. No experimental drugs or procedures are involved.
How do I enroll? From the study team
Register your interest using the form on this page. The research team will contact you within 5 working days to confirm your eligibility and guide you through the next steps. You can also visit the study platform directly at diabetesreversal.io or contact the research team at dr.snouda@hotmail.com.
How to find out more
Dr. Salah Snouda, MD
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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