Posted , 7 users are following.

my husband has been takin Amlodopine for the past 6 weeks, he is now suffering with very hot knees.  Could this be a side effect of this drug?

0 likes, 22 replies

Report / Delete

22 Replies

  • Posted

    If you google side effects, the most common is fluid retenion and I got that after 30 days in my right ankle....took higher doses of grape seed extract and got rid of it.

    I don't have the hot knees, but do deal with OA in right knee the worst and it's quiet in the left knee....they don't burn though.

    Everyone is different and it could be affecting your husband like this. Do check the side effects lists.

    Report / Delete Reply
    • Posted

      Thanks Joy have checked side effects, but no mention of this.  I had the swollen ankles and was taken off it, but this is the only thing we can think is causing it.

      thanks anyway for replying.

      Report / Delete Reply
  • Posted

    Hi Janwhy - the hot knee syndrome is one of the symptoms I had but did not relate it to the drug because I had broken my leg at the time and was suffering with different things to do with the break and when I told my physio he said it was all due to a trapped nerve and that was causing the hot knee business. Since coming off Amlodipine that particular problem has gone away and now realise it was the drug not complications to the broken leg. Hope this helps in some way.
    Report / Delete Reply
  • Posted

    I have swollen ankles (left one is the worst) which often feel warm to the touch. I haven't had any problems with my knees - yet.

    I am going to try the grape seed extract which Joy mentions.

    Report / Delete Reply
  • Posted

    I took this drug for 2 weeks. the doctor wanted me back after 2 weeks to check on me. when i went back in the soles of my feet were burning so bad. From the feet all the way up to the knees i was red. needless to say the blood pressure was still high so she doubled it. i took it 2 more days and i quit it because i started having severe knee pain and it even started feeling like someone had put something around my ribcage and had tightened it. needless to say after a few days all the redness started going away, the breathing got better, and i started feeling like myself. i changed doctors and are having no more problems. that drug scares me. i will never take it again.
    Report / Delete Reply
    • Posted

      thanks for your reply, he is now complaining about hot feet and head aches, I think he needs to see GP sooner rather than later to get this sorted.  Sorry you suffered too.  Hood it's sll sorted now.
      Report / Delete Reply
  • Posted

    To make it short.....YES. This drug has a HOST of side effects.  Polyneuropathy is just one of them. Hot knees, hot face, hot really just depends on WHERE the drug decides it's going to effect each individual. Everyone is different. Go thru this entire blog and you will find so many different side effects people have suffered. And you can always look them up for yourself at
    Report / Delete Reply
  • Posted

    I hope they will post my reply to you...get him off the med.
    Report / Delete Reply
  • Posted

    amlodipine Side Effects

    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur:More commonSwelling of the ankles or feetLess commonDifficult or labored breathing


    fast, irregular, pounding, or racing heartbeat or pulse

    feeling of warmth

    redness of the face, neck, arms, and occasionally, upper chest

    shortness of breath

    tightness in the chest

    wheezingRareBlack, tarry stools

    bleeding gums

    blistering, peeling, or loosening of the skin

    blood in the urine or stools

    blurred vision

    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

    chest pain or discomfort


    cold and clammy skin

    cold sweats


    dark yellow urine



    dilated neck veins

    dizziness or lightheadedness when getting up from a lying or sitting position

    extra heartbeats

    extreme fatigue



    itching of the skin

    joint or muscle pain

    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

    numbness and tingling of the face, fingers, or toes

    pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion

    painful or difficult urination

    pale, bluish-colored, or cold hands or feet

    pinpoint red or purple spots on the skin

    red, irritated eyes

    redness of the face, neck, arms, and occasionally, upper chest

    redness, soreness or itching skin

    shakiness in the legs, arms, hands, or feet

    slow or irregular heartbeat

    sore throat

    sores, ulcers, or white spots on the lips or in the mouth

    sores, welting, or blisters

    sudden sweating


    swelling of the face, fingers, feet, or lower legs

    swollen glands

    trembling or shaking of the hands or feet

    unsteadiness or awkwardness

    unusual bleeding or bruising

    unusual tiredness or weakness

    weak or absent pulses in the legs

    weakness in the arms, hands, legs, or feet

    weight gain

    yellow eyes or skinIncidence not knownAbdominal or stomach pain

    clay-colored stools



    loss of appetite



    unpleasant breath odor

    vomiting of blood

    yellow eyes or skin

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less commonAcid or sour stomach




    lack or loss of strength

    muscle cramps

    sleepiness or unusual drowsiness

    stomach discomfort, upset, or painRareAbnormal dreams


    back pain

    bad unusual or unpleasant (after) taste

    bleeding gums

    blistering, crusting, irritation, itching, or reddening of the skin


    bloody nose

    burning feeling in the chest or stomach

    burning while urinating

    burning, dry, or itching eyes

    change in color of the treated skin

    change in sense of smell

    change in taste

    changes in vision


    continuing ringing or buzzing or other unexplained noise in the ears

    cracked, dry, or scaly skin

    decreased sexual performance or desire


    difficulty with moving

    difficulty with swallowing

    discharge, excessive tearing

    double vision

    dry mouth

    dryness of the skin

    excess air or gas in the stomach or intestines

    excessive muscle tone

    eye pain

    feeling of constant movement of self or surroundings

    feeling of unreality

    feeling unusually cold

    flushed, dry skin

    fruit-like breath odor

    full feeling

    general feeling of discomfort or illness

    hair loss or thinning of the hair

    headache, severe and throbbing

    hearing loss


    increased appetite

    increased hunger

    increased sweating

    increased thirst

    increased urge to urinate during the night

    increased urination


    irritation in the mouth

    lack of feeling or emotion

    loose stools

    loss of memory

    muscle pains or stiffness

    muscle tension or tightness

    muscle weakness



    pains in the stomach, side, or abdomen, possibly radiating to the back

    passing gas

    problems with memory

    redness and swelling of the gums

    redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid


    runny nose

    seeing double

    sensation of spinning

    sense of detachment from self or body

    shakiness and unsteady walk




    stuffy nose


    swollen joints

    tenderness in the stomach area


    trouble in holding or releasing urine

    trouble sleeping


    unable to sleep


    unexplained weight loss

    unsteadiness, trembling, or other problems with muscle control or coordination

    waking to urinate at night

    weight lossIncidence not knownSwelling of the breasts or breast soreness in both females and males

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional

    Report / Delete Reply
  • Posted

    You both are most welcome! I don't want to see anyone else suffer from this med. After what I have to now live with, I'd like to see this drug banned. And if someone does CHOSE to take it. Then by all means take it at your own risk. If you need anything else I can support you with please just let me know and please update us on his condition.
    Report / Delete Reply
    • Posted

      I would certainly agree on that - I wrote on a different thread, about the same drug, a few years ago.

      I should add though that among my side-effects, I added considerable weight gain (close to three stone), rather than weight loss. I have lost most of the surplus, but not all of it. My legs however are not great.

      Report / Delete Reply
    • Posted

      Hi Michelle, he has seen GP on Friday and told him about the side effects he was suffering, but the he just brushed it off and when he took his blood pressure, which was 156/91, he then prescribed Lorsartan 50mg 1 per day on top of the Amlodipine.  He has to see him again on the 14th November for another BP test.


      Report / Delete Reply
    • Posted


      Read your post, hopefully if the side effects are gone things will go ok. please just keep an eye out and don't hesitate to go back to see the dr if they don't.


      Report / Delete Reply

Join this discussion or start a new one?

New discussion Reply

Report or request deletion

Thanks for your help!

We want the forums to be a useful resource for our users but it is important to remember that the forums are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the forums is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.

newnav-down newnav-up