Can I take Mirtazapine and Sertraline at the same time?

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Hey guys,

I've been taking mirtazapine (15mg, night time) and sertraline (100mg, morning) for 2 years now and it's been superb. However, I'd like to try taking the mirtazapine and sertraline BOTH at night-time. Does anyone know if this is safe to do?

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  • Posted

    Hi can I just ask why you want to take the sertraline at night?

    I can understand the mirtazapine as it has a sedativebiggrin

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    • Posted

      Hey Lynne,

      Sertraline seems to flare up my IBS, particularly in the first few hours of taking it. I figure if I take it at night with Mirtazapine I should be able to sleep through the worst of the gut side-effects!

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  • Posted

    Hi I don't no if you can do that but I always took the sertraline at night anyway .. I'd wana go to sleep when id take it in the morning & yawn alday long.. I took mine with lithium or quetiapine. .

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  • Posted

    Hi venusia,

    ​Personally  would not take Mirt. and Sertraline at night, not without seeing your GP first. If you have felt ok for the last 2 years why change?.

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    • Posted

      I agree with Baz, ask your doc before making any changes.  ADs can be activating so it may mess with your sleep if you switch.  If your doc is ok with it, then I'd recommend making the switch gradually.  If it is possible to break your tablet down into quarters, take 3/4 AM and 1/4 PM for a couple of days, and then 1/2 and 1/2, then 1/4 and 3/4 and so on.  If you notice that your sleep is disrupted or any other odd symptoms crop up along the way, you can return to the way it was before with less trouble.
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    • Posted

      Great advice there Betsy, as always.

      I would go along with this, always best to tread carefully, if you disrupt the systsem it may be difficult to put it right afterall.

      Wishing you well.

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