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Can I take Mirtazapine and Sertraline at the same time?

Posted , 21 users are following.

Guest
Guest

Hey guys,

I've been taking mirtazapine (15mg, night time) and sertraline (100mg, morning) for 2 years now and it's been superb. However, I'd like to try taking the mirtazapine and sertraline BOTH at night-time. Does anyone know if this is safe to do?

0 likes, 39 replies

39 Replies

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  • fi55
    fi55 Guest

    Posted

    Hi, I have been on Setraline for over a year now, dose increased to 100 mgs in last few months. I just want to sleep all day, have no motivation to do anything. Feeling very sloth-like. I am so desperate to wake up bouncy on the mornings, and feel full of energy. I went to my GP yesterday, and he suggested Mirtazipine 15mgs nocte instead of Setraline. His advice is to wean off Setraline and then commence Mirtazipine. I am praying that this will change my life! I am 61 yrs old, and want so much to enjoy left again. I have no reason to be depressed! It is annoying. Any thoughts, please. 
  • sheron67167
    sheron67167 Guest

    Posted

    Hi venusia94, I used to take sertaline 50mg alone and did not help. I then started on 11.25mg of mirtazapine to help with my appetite and sleep. Now going to sertaline 25mg for anxiety (then upping to 50mg) and mirtazapine at night... how has the two worked out for you and are you still on both today?! Thank you.
  • kimberley_31372
    kimberley_31372 Guest

    Posted

    Hi I have been prescribed sertraline and I am on 30mg of mitazapain I am very depressed ATM I have started my menopause so I am on femoston hrt the doc has given me 50mg of sertraline do you think I should start taking them together I am worried about it or do you think I should see another doctor first 
  • Calmer
    Calmer Guest

    Posted

    Check it out on an interaction checker like  d r u g s . com or google it and see what comes up - you may well be led back to this site.

    There is a lot of talk about Estrogen replacement "naturally" for women who hit the menopause and feel depression, ask your doc or research that, its what Carol Vordaman took, although I guess she paid megga bucks, might be a more affordable version somewhere ~ just a though smile  

    Wishing you well.

    • leena63352
      leena63352 Calmer

      Posted

      The drug interactions checker will tell you that there are major interactions between these two drugs. It is better to listen to the advice of your doctor or Psych. I have been on 15mg of Mirtazapine to help with sleep for seven weeks (works wonders) and today just started on 50mg of Sertraline in the morning to lift the depression/anxiety as the Mirt wasn’t helping in this area. If I had followed the drug-checker advice I wouldn’t have done this combo but my doctor said it was Ok. Always follow your doctors or Psych’s advice (rather than things you read about on the internet). If things don’t work out go back to them and try again. 
  • Gretel
    Gretel Guest

    Posted

    I would keep 1 in the morning and mirtazapine at nite, as prescribed. Especially if its working.
  • paula48024
    paula48024 Guest

    Posted

    I've been on 200mg of sert for 18 months been feeling so bad Dr gave me 15mg of Mir to help my mood and sleep . Took it last night couldn't wake up . Does this improve ? To be honest my concern is weight increase. I struggle as it is to lose weight . Is this a problem for anyone else ?

    • Gretel
      Gretel paula48024

      Posted

      Paula, i gained 40 lbs in about 4 months while on it. Been off 16 weeks and have lost 5lbs with workout, walk and 1 salad/day.
    • SerotoninSurfer
      SerotoninSurfer paula48024

      Posted

      Hi Paula, are you still on combination of Sertraline and Mirtazapine? Wondered how you are now?

  • UKSteve
    UKSteve Guest

    Posted

    Yes

    Its a very commonly prescribed combination particularly for treatment resistant depression or to improve sleep or anxiety in patients who are overstimulated by sertraline on its own.

    The risk of serotonin syndrome is very low because Mirtazapine is not an SSRI and so has a different serotonin mechanism along with norepinephrine.

  • Nipnap
    Nipnap Guest

    Posted

    Do UK docs approve of taking Mirtazapine and Setraline in combination or is this just in the US? I am taking M, but not finding it wholly effective. I used to be on Sertraline and found it okay but weaned myself off it and then had major depression, hence now on the Mirt. Quite like the idea of taking both drugs in combo. But wondering whether a UK doc would approve it?

    • janz70
      janz70 Nipnap

      Posted

      Hi, My GP has just put me on this combo today - so I was looking for further info and found this thread.

      I on am on Mirtazipine 45mg (max dose) taken at night to help me sleep - started on 15mg in october then 30mg then 45mg as it was helping me cope but wasnt stopping or reversing the depression, so my GP has decided to try combining with Sertraline 50mg / folic acid 5mg / cyanocobalamin 50ug these apparently work together to make the sert more effective and lift mood.

      I know these cant possibly working yet as its the very first time I have took them today but I actually feel normal, even slightly good. Is it possible for these to have an effect within hours?

    • SerotoninSurfer
      SerotoninSurfer janz70

      Posted

      How are you doing on this combo now janz70? Hope they're working for you?

  • SerotoninSurfer
    SerotoninSurfer Guest

    Posted

    Yes you can. I've been on Sert and Mirt combination since Sep'18

  • charles98819
    charles98819 Guest

    Posted

    Hi Guys

    have been on mirt for 12 years now. last 2 years went down to 15mg. Have been having quite some anxiety and my Psy said I should start Sertraline 50mg in the mornings and 15mg mirt at night.

    please I need to know what to expect?

    • janz70
      janz70 charles98819

      Posted

      I have just been put on sertaline 50mg with mirt 45mg on a night - sorry but your post suggests you have been on it for 8 weeks now - perhaps you could answer your own question for me.

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