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I have had chronic hives for almost 18 years and sometimes for a whole year at a time. My docs never had answers and always prescribed the usual antihistamines with little or no success. I finally started to do some research and discovered a few trials using Sulfasalazine and asked my doc if I could try it. He was reluctant at first but finally let me try it. It takes time to work (about 4-6 weeks) but has resolved all my recent flares !
When I initially get the hives, I treat it with prednisone (10 mg for 2-3 days) and once my skin is clear, I start on the Sulfasalazine (2-3 500 mg pills per day). If I'm still getting some hives, I take a Zantac, especially before meals. In approx. 4-6 weeks the hives are gone and stay away for a very long time. Of course, I will get another flare in the future and will treat it again. As you probably know, when you're having a flare you should eliminate any high histamine foods from your diet - at least for a while. I do hope this helps someone else with chronic hives caused by delayed pressure.
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