Finally sorted my ED changed to tadalafil!

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After 15 years on tamsulosin 400 micrograms daily I discovered tadalafil (cialis) 5mg daily is now an option for BPH. ED had become a real problem but after less than a week the ED is barely evident and retrograde ejaculation is no longer the norm..  I feel much better too. I am so glad I had a chat with my GP and he changed my prescription

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  • Posted

    That's great news!

    How much would you say Cialis has releived your BPH symptoms and made it easier to pee?

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    • Posted

      Urine flow rate no better and no worse so far but I have only been on them 5 days .. I will keep everyone posted though
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  • Posted

    Daily Cialis has been approved for BPH for a number of years now.  Glad it's working for you. I preferred it to Tamsulosin as well.

    Jim

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    • Posted

      Tamsulosin -- retrograde (dry) orgasm, no change in erections.

      Daily Cialis -- no retrograde orgasm, some enhancement in erections. 

      I found both improved bph symptons about the same but not significantly, and the improvement seemed short lived. Others have had both better and not as good results. 

      Side effect wise, I found both similar with slight blurry vision, and mild occasional headaches, if I remember correctly. Daily Cialis gave me (and some others here) heartburn, which I'm sensitive to. I was able to eliminate the heartburn by taking one OTC Prilosec a day, one hour before breakfast, but antacids might be all you need if you happen to get it. 

      Jim

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    • Posted

      I am already on omeprazole to counteract the effects of the NSAIDs I take on my stomach so heartburn wouldn't be an issue.I am already on two meds for hypertension but on cialis the daily reading is still textbook at around 123/72. Blurry vison I am still evaluating but I think i may be getting a little. Headaches none yet.. on blance I am loving the improvements. Nocturia frequencey unchanged .. stil 2 to 4 times nightly but I still manage a total of 6 - 8 hours kip

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  • Posted

    That is great news, did your insurance cover the cost? About 3 years ago my Doc tried to switch me to the daily also. It worked great, amd even lowered my blood pressure. However my insurance refused to cover it for BPH. Im just wondering if something has changed and now they do?

    thanks

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    • Posted

      I believe the Medicare Rx plan picks up some of the cost. If I remember correctly, around $100 a month out of pocket.

      Jim

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    • Posted

      I am in the UK and our national health service cover it.. I wish I had known earlier but had always thought Cialis a recreational drug.
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    • Posted

      They cover it but normally it is for only one pill a week.

      I once had a stroke of luck when a Polish pharmacist did not understand my GP's prescription and took it to be one a day for the two month prescription. He apologised for not having enough in stock and said he would get the balance for the next day.

      Fortunately the one checking the prescription was also Polish. I did tell my GP and he laughed at my good fortune.

      Being a Senior citizen I don't have to pay for my prescriptions.

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    • Posted

      That's a funny story Derek! Are you sure it wasn't one 20mg pill the covered for the week, as opposed to the 5mg Daily Cialis? 

      Jim

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    • Posted

      I should have said it It was a 20mg tablet but the effect only lasted for about the 36 hours as expected.
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    • Posted

      I forgot the half life chart but it does run out after 3 days. With 5mg Daily Cialis, you build up to around an 8mg serum dose, which is only a third of what you get from the 20mg, but it does work.

      Jim

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    • Posted

      Go to the Cialis web site. They usually run an introductory one month free, or money off offer. I think it was one month free when I started. Also, your doc should have samples in his drawer unless he's taking them home smile

      Jim

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    • Posted

      Lol I have a pretty smart Doc so Im betting he keeps all of those. I will definitely check out the web site tho and see if they will cover it now. I swear it brings my blood pressure down better and more stable than my regular b/p med does
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    • Posted

      The NHS covers Tadalafil only if you meet certain criteria such as pelvic surgery - including prostate surgery.  The patent for "use before sex" Tadalafil expires at the end of this year so prices should drop if you have to pay for a private prescription, however the patent for 2.5mg and 5mg one-a-day will remain.  5mg per day is the only one licenced to treat both BPH and ED so unless you meet the NHS criteria you will have to pay.

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    • Posted

      @Grunthos: The patent for "use before sex" Tadalafil expires at the end of this year so prices should drop if you have to pay for a private prescription, however the patent for 2.5mg and 5mg one-a-day will remain.

      ---------------------------------

      Sounds like buying 20mg Cialis and a pill cutter may be in order!

      Jim

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    • Posted

      Mine is free as I am 70 years old and don't pay for scrips. It is now on my regular repeat prescription. The only surgery I have had is 3 biopsies and then refused the greenlight laser removal of part of the prostate. I kind of think GPs interpret the guidelines as they think is fitting

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    • Posted

      ..buying 20mg Cialis and a pill cutter may be in order!

      Ha ha! This is one of those situations pilling cutting won't work. 20mg Cialis costs more than 4X 5mg. Haank

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    • Posted

      As they are a coated slow release tablet they are not supposd to split but if they are perhaps the reaction is quicker 
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    • Posted

      Hank,

      "Grunthros" just reported that the patent for Cialis runs out this year suggesting significant savings, but only in the 20mg format. 

      Jim

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    • Posted

      Hank,

      "Use before sex" is generally 10 or 20mg. From memory, if you compute the blood concentration of Daily 5mg Cialis, using the half life formulation, you multiple times 1.6. So that means the blood concentration of someone on 5 Daily mg Cialis is 8mg after a week or so.

      Jim

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    • Posted

      Jim, I still don't get it. Are 20mg and 10mg imply "use before sex", and 5mg and 2.5mg imply "one-a-day" ? Hank

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    • Posted

      It's marketing sort of. 

      2.5 and 5mg Cialis are marketed for once a day use, for bph/lus.

      20mg and 10mg are marketed for "use before sex" or the "weekend pill". 

      The reality is that if you were on Daily 5mg Cialis for awhile, on any given day, the concentration of Cialis in your system would be 8mg, almost the same as if you took a 10mg "use before sex" dose. 

      Now, if you had a "big" night planned, I suppose you could take another 5mg tab which would bring you up to 13mg, or alternatively another 10mg tab, which would bring you up to 18mg. Doing so are off label, and warned against, and I had a big "discussion" with my former urologist about this trying to explain to him that taking another 5mg once, is not more harmful than a person not on Daily 5 mg Cialis taking 13mg once. But no, he just kept referring back to the label instructions, and then my 20 minutes were up!

      Jim

       

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    • Posted

      Thanks. My medicare rx plan here in the U.S. pays for only part of Daily 5mg Cialis. It ends up costing around $100 a month out of pocket, or at least that's what it cost a year or so ago when I last used it. 

      Jim

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    • Posted

      Haha. Maybe I made it too complicated, I'll try again. 

      Originally Cialis came in a 10 and 20mg version and was marketed/used for ED. Because it had a longer half life than Viagra, it was called the "weekend pill" because a 10 or 20mg dose could give erection benefits for 2 to three days. 

      Then, later on, they found out that lower doses of Cialis, taken daily -- namely 2.5 mg and 5mg -- had similar benefits for BPH as alpha blockers like tamsulosin. So based on these results they then came out with a 2.5mg and 5 mg version of Cialis. 

      But since it's really the same drug, just different doses, the smaller doses -- 2.5 and 5mg versions also help erectile function just like the larger 10 and 20mg doses, just probably not as much. 

      As to the "before sex" that is just the instructions for the larger doses because they are generally not prescribed for bph on a daily basis, but just before sex on a once a week or so basis. 

      Likewise, the rx for Daily 5 or 2.5mg Cialis is written/indicated for BPH, with the instructions "take daily" because that is the indication for it. 

      Hopefully that's clearer, but if not, ask away. I just had my Omega 3 sardines so my brain should be firing on all cylinders!

      Jim

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    • Posted

      Thanks Jim, I think I understand it now. The only thing that is still puzzling me is how you use half life formulation to come up with 1.6 factor and conclude that 8mg (1.6 x 5mg) of Cialis is in the blood. I know what a drug half life is and that's about it. Perhaps if I had sardines for dinner, I might understand better. Unfortunately, I only had tuna. smile Hank

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    • Posted

      The 8mg (1.6 x 5) is from memory, but I'm pretty sure it's either on the money or very close. While it's based on the half life, that's not how I figured it out. I found the numbers in a paper or study after researching it out. My urologist didn't have a clue nor did the person at the Cialis information line. I wanted to know so I could compare the drug level of 5 mg daily Cialis against a single dose of Cialis 

      Jim

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    • Posted

      Well, I guess the sardines do help smile

      From a study on ncbi.nlm.nih.gov,  titled "A once-daily dose of tadalafil for erectile dysfunction: compliance and efficacy"

       

      "...Tadalafil has linear pharmacokinetics over the dose range of 2.5–20 mg.12 A steady state of tadalafil is reached after 5 days of daily administration, with a plasma concentration that is roughly 1.6 times higher than that of a single dose.12 In other words, cumulative plasma exposure at steady state of a 5-mg daily dose corresponds roughly to an 8-mg on-demand dose..."

      Jim

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