For those taking a split dose of Pred when do you take your second dose.

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My doctor is reluctant to put my dose of Pred up from 9mg to 10 mg  so want me to take a split dose, as the pain wears off during the day , l aim to take the first dose after my breakfast in the morning and not sure what time to take my second dose. Doctor said that if I am still getting some pain after a few days to go up to 10mg. Thank you

 

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  • Posted

    I take my 10 mg split-dose 4 mg after breakfast and 6 mg after tea.  On a single dose, I was only pain free overnight.   
  • Posted

    I was taking 1/2 in the morning and 1/2 just before bed ( very late, 1AM). Some people have  problem sleeping with late dose though, so you have to try and see.  The reason for very late dose is that is the best, most effective time to take pred. If you are taking non-coated pills, it takes 2-3 hours for pred to have maximum concentration in the blood stream, and it almost coincides with release of cytokines at 4-4:30AM
    • Posted

      I have had no trouble sleeping on a split-dose.  In my experience, prednisolone takes 10 hours to affect PMR pain.  I tried a 2 am dose to no avail.
    • Posted

      Sorry it does not work for you, but for most people that is the optimal time to take meds.  This is one of the main reasons that doctors  recommend taking prednisone as early as possible in the morning. Alternative, of course, is to take it very late (1-2AM) for the same reason. 

       

    • Posted

      Nick67069, that's very interesting. I am up until midnight every night. I may switch my dose to that time for a night or two to see if it's better and how badly it affects my sleep, which is already fairly patchy. Thanks.

    • Posted

      It SHOULDN'T take that long to improve PMR pain. Are they sure it is PMR?

    • Posted

      I have had next to no PMR pain since Christmas.  When I do experience mild PMR pain, the prednisolone takes 10 hours to have any effect.  Maybe my very high fibre diet is a factor.
  • Posted

    Jennyrose, I split my dosage and have been since last June. First after breakfast in the morning, then after shack just before bed. I have found that works for me. Good luck! ☺️
  • Posted

    My second dose is 10:30 to 11 PM, up in the morning 5:30 to 6 am. Normally sleep okay, most nights once to bathroom, some nights I sleep through. ☺️
  • Posted

    You need to take the second part of the dose a couple of hours before you would expect the pain to break through, maybe 3 hours depending on how long your pred takes to work. Everyone is different though.
  • Posted

    Thank you everyone I have taken my second dose after my dinner but I think tomorrow I’ll start taking my Pred just before bed . I felt very strange this morning thought that it might be some sort of withdraw symptom as my Body was used to 9mg  😢

    • Posted

      Taking the second dose just before bed is no good on an empty stomach..

    • Posted

      true.. that is why I take 3-4Oz of yogurt and banana at the same time. Never had issue.
    • Posted

      Hi Joydeck. I thought that I would take my Pred with fruit and a little yogurt , I normally go to bed between 9 and 10 so will take it as late as possible. 😊

    • Posted

      Ahh this is what I plan to do 😀 thank you

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