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For those taking a split dose of Pred when do you take your second dose.

Posted , 11 users are following.

Royall
Royall

My doctor is reluctant to put my dose of Pred up from 9mg to 10 mg  so want me to take a split dose, as the pain wears off during the day , l aim to take the first dose after my breakfast in the morning and not sure what time to take my second dose. Doctor said that if I am still getting some pain after a few days to go up to 10mg. Thank you

 

0 likes, 22 replies

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  • reggie92967
    reggie92967 Royall

    Posted

    I have been on split dose for 4-yrs. now been at 10mg. for about 7-8 months, but just dropped to 9.5 mg., although think I'm having negative side effects. I take 5mg. early a.m. 6:00a.m. & 2nd dose 4m5mg. about 5:00p.m. I have never felt quick relief after taking my prednisone, like one does with aspirin, tylenol, motrin, etc., Always thought prednisone was a longer more half life type drug, & have to keep in your system type drug ?

    • reggie92967
      reggie92967

      Posted

      Sorry I meant 4.5mg in p.m. about 5:00.
    • EileenH
      EileenH reggie92967

      Posted

      The plasma half life of pred is about 2-4 hours. The longer halflife steroids are dexamethasone and co.
    • EileenH
      EileenH

      Posted

      Should have added that, although the plasma halflife is under 4 hours, the duration of EFFECT of pred is from 12 to 36 hours, depending on the person, i.e. the effect lasts far longer than the pred is present in the body.
    • Royall
      Royall reggie92967

      Posted

      Hi there, it normally takes about 3/4 hours for the Pred to work on me. Hopefully the split dose will keep me pain free all the time. 😀

    • Michdonn
      Michdonn EileenH

      Posted

      EileenH, that explains why the small dose at bedtime helps me feel better in the morning, before my larger dose.

      Thanks again, ☺️

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