how many times do you get up with enlarged prostate for a wee ?

Hi John, Before and After medication about the same a good night 2 and bad night 4 over 7 hr period.

Discovered that going to bed later say 11 or 11:30pm till 6am is better with average 2 times. But John my problem is that I have for 20yrs or more been getting up 2 times well before prostate issues, so I can live with that. Night time urination is harder to start though and my gen surgeon friend says thats normal.

Medication I've been prescribed is Duodart for 6 mths now and can take 3-12 mths to take effect - trials for the drug went 2-4 years so for some can longer than 12mths I noticed improvement 3mths. Stronger flow.

But 2 weeks ago it dropped off smyptoms are slow stream, frequency but dont have symptoms of bladder not being empty. Docs at a Pub Hosp recently said it was prostate decompeensating for medication don't know John.

Duodart can reduce prostate up to 30% if you're lucky. No side effects for me other than 50% RE.

Hope my reply is useful.

I am using Avodart and Ciallis. It seems to be helping. I tried flomaxtra and couldn't tolerate it. If you google Drugs for enlarged prostate you will find about 40 different ones. They fall into two classes. Ones that shrink the prostate and ones that relax soft tissue. For me Avodart is for shrinking the prostate and Ciallis is for relaxing the soft tissue.

I am currently waiting to see if I can have a Prostate Artery Embolization or PAE. There are a bunch of new procedures available. Beware of doctors who have a large vested interest in an expensive machine. If you have a hammer everything looks like a nail.

Other causes of frequency.

https://patient.info/doctor/urinary-frequency

 

Do read the side effects of dutasteride and finasteride same thing 5-ARI drugs. If you're bald some may grow back but you can grow man boobs and get ED, and the latter may not go away when you stop. Also possible reduced libido. I didn't try it, urologist persuaded me not to. Hair clinics apparently use same drug as their only non transplant trick. And charge you £2000 for it. Joke.

Diet n lifestyle change works wonders.

I was treated for Benign Prostate Hyperplasia/Hypertrophy (BPH) since 1990. In 2006 I was prescribed Alpha-blockers (Flomaxtra then Prazosin) 4mg a day. They still left some voiding difficulty and overnight necessities. Bladder capacity was shrinking. There was no consideration of the impact 9 years of Alpha altering of bladder neck/urethra muscles and nerves might have if a prostatectomy were to follow. I did not know that since 1995 urologists had known Prazosin would need an increase in its 4mg dosage beyond 2 years. By 2015 still no one had bothered to do the research. Pharmaceutical companies do all the research and they don’t if there’s no billion dollar benefit in it for them. When Prazosin became a little less effective and I requested an increase to 6mg a day Duodart was prescribed March 2013 to March 2014. Gleason Score 3+4=7 and Open Radical Prostatectomy followed in November 2015(at 72 years). A long and hard partial recovery and so far 2 years of incontinence followed. An emergency hospital botched blockage treatment then causing possible permanent bladder neck damage and months of self catheterising. My 25 years of PSAs never went above 3.8 (Apl 2009) and it was 2.41 (f/t38%) in July 2015 long after 5ARI affect on IT had ceased.

Research shortly after RP alerted me to concern that Duodart may increase risk of high-range PCa. My then urologist said this only related to a different 5ARI drug and then only “serious” PCa “which yours isn’t”. It was serious enough for me. I have spent 2 years trying to get some answers. No one can tell me if Gleasons 3+4 progress to 8s and 9s or if they just become more aggressive 7s. If there are 2 different types of BPH with growth in number or size of cells. Duodarts’ Australian supplier discounts any increased risk from pre-release trials as a fault in the study’s design. There has been no attempt to redo the trial without this design fault. Our Commonwealth Ombudsman says only trial adverse side effects need to be recorded as such on information provided to consumers with the drug. Subsequent adverse effects do not have to be advised and therefore Urologists do not complicate their prescribing and cause any problem with sufferers “risk vs benefit” consideration.

The Australian supplier of Duodart has reported 5 suspect “de-identified cases” of Prostate Cancer to our Therapeutic Goods Administration’s (TGA) Database of Adverse Events(DAEN) yet PCa still doesn’t appear in the side effects of Duodart’s Consumer Medicine Information supplied with the drug. TGA says drug suppliers are legally bound to report “serious” adversities to them but allow the company to report them without age, other medications or Gleason Scores. The only distinguishing factors are the company’s notification date. They could be anyone. Urologists are required to prescribe initial doses of the drug and appear to be the only source for any supplier’s fulfilment of their legally required reporting. Many urologists have decided not to let me know their feedback regime. The supplier informed me they reported my adverse reaction but submission dates indicate they did not.

Dutasteride is supposed to mostly reduce prostate size by abnormal manipulation of its cells. My research has indicated that it mostly does this but it appears that when it fails to achieve this reduction it does something else. If the supplier can isolate their 5 mystery, suspected PCa from the rest of their user PCas I hope they didn’t have a way to do this ahead of our drug use. If you are having voiding and size reduction benefit you are likely on a winner others may not be. UK appears to have more locally readily available BPH treatments than Australia. Do the research and communications to ensure you don’t make our mistakes. Barrie

Hi John,

In addition to an obstructive prostate, there are other things that can effect the frequency of nighttime urination. They include the amount and schedule of fluid intake, diet composition and sodium intake, exercise and diuretics like coffee and alcohol. Nighttime urination can also be caused by a hormonal shift as we get older as well as heart efficiency, diabetes, blood pressure and kidney function. 

There is a fairly simple low tech way to help isolate the cause of your night time urination. Do a 24 hour void log where you write down the time and amount of each void. If over 40 per cent of your void is at night, then the reason for your night time voids may be other than your prostate although it still could be a combination of factors. Knowing your post void residual is also helpful.

Jim