LDN - Low Dose Naltrexone and chronic pain
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I've been on LDN - Low Dose Naltrexone for a few months now. It's been a bumpy road and the journey has had both positive and negative points.
I've been adjusting the dose but in so far the 3 main benefits I can claim from it are:
- some sleep improvement;
- less pain intensity;
- apparent normalising effects on some blood markers such as LDH (lactate dehydrogenase).
However I feel exhausted to an unbearable point and continue prone to inflammation. I've decided to continue treatment with LDN because I've read extensively about it and many authors say it may take up to a yer to come to fruition.
Meanwhile I've resorted to naturopathic medicine and I'm under treatment as well.
We're all different in the way we react to medications and because I've been reading so much suffering here with so little hope of remission that I thought of encouraging you of not giving up and trying new things.
I would like to share with you a recent study on LDN whose Abstract is:
"The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic painJarred Younger, [corresponding author] Luke Parkitny, and David McLain
Abstract
Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells. These effects may be unique to low dosages of naltrexone and appear to be entirely independent from naltrexone’s better-known activity on opioid receptors. As a daily oral therapy, LDN is inexpensive and well-tolerated. Despite initial promise of efficacy, the use of LDN for chronic disorders is still highly experimental. Published trials have low sample sizes, and few replications have been performed. We cover the typical usage of LDN in clinical trials, caveats to using the medication, and recommendations for future research and clinical work. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders.
Keywords: Anti-inflammatory, Chronic pain, Fibromyalgia, Glial cell modulators, Low-dose naltrexone, Microglia"
Younger, Jarred, Luke Parkitny, and David McLain. “The Use of Low-Dose Naltrexone (LDN) as a Novel Anti-Inflammatory Treatment for Chronic Pain.”Clinical Rheumatology 33.4 (2014): 451–459. PMC. Web. 13 July 2015.
1 like, 75 replies
kaz_40 TeresaJS
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TeresaJS kaz_40
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You never forget asking do you? How sweet of you!
I'm a bit better guess, than you. In the last few days I ate some wheat breads and... I can tell you that it makes me feel worse. I know I can't have them more than once a week but I relapse and then I pay the price. In my case I feel it really impacts on fibro.
It's shame you're not sleeping more Karen... you know it'll also impact on your health. It's chicken and egg situation, I know. Have you asked your doctor if the leg pain isn't also related with poor circulation? Because if it is you can take bioflavonoids and other helpful things. But I know numbness is very common in fibro patients - I have every night usually in hands and arms.
Is Charlie well now?
I wish you a peaceful and joyful weekend. XXX. Teresa.
kaz_40 TeresaJS
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TeresaJS kaz_40
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kaz_40 TeresaJS
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TeresaJS kaz_40
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loxie kaz_40
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Take care ladies (and gents if any are reading), I'm off to pack now and won't be online til I get back next Friday. Big gentle hugs and stay safe. xx
TeresaJS loxie
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kaz_40 TeresaJS
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kaz_40 loxie
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TeresaJS kaz_40
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loxie TeresaJS
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TeresaJS loxie
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kaz_40 loxie
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kaz_40 TeresaJS
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TeresaJS kaz_40
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My prayers go out to you. Have blessed night. XXX T.
kaz_40 TeresaJS
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