Mirtazapine withdrawal
Posted , 45 users are following.
If anyone could share some of their experiences and perhaps advise on when this nightmare is going to end I'd really appreciate it.
I’m 34, otherwise healthy, started Mirtazapine (in some sense against my instincts) about two years ago due to severe anxiety (no depression at all) and panic attacks. My Doctor prescribed Mirtazapine 30mg, to be tapered upwards from 7.5mg.
I remember the first few days I felt a weird sensation when swallowing (simply felt like uncoordinated swallowing, where the food/drink seemed to be going at the wrong velocity towards its target). However, after a while and increasing dosage this symptom vanished more or less.
Fast forward about a year and a half forward, and (apart from helping my IBS by making me numb) - the drug was totally useless anxiety-wise. I was still feeling very bad. True, I had not gotten many panic attacks, but I found that they were just transposed with a very generalized anxiety which I believe (self-diagnosed) had almost become a phobia: I became afraid of trying new things altogether from fear of having e.g., an allergic reaction (never had any of those ever in my life and never feared them before either). I had quit sports because I could not stand the sensations involving an increase in heart rate or blood flow. Done all of the tests and all is fine with my heart and everything else for that matter. It’s all in the head but the head controls your body and your mind.
The Mirtazapine just made me numb; I could feel less love to my fiancée (now wife!) and cared less about the world in general. Realizing that I had just become more anxious (if less panicky) the Doc upped the dosage to 45mg. What a disaster. More than a month afterwards I was just getting more and more anxious on a daily basis.
Eventually, AMA, I decided that going on Mirtazapine was the biggest mistake of my life. I started tapering, very VERY slowly. I think I went from 45 to 15mg with relative ease, taking more than two weeks at a time to decrease the dosage by 3-4mg at a time. Each time, I would feel great for 2 days, then start developing quite severe cramps and feel lousy for another week or so, then I’d get slightly better. Knowing that I am really ultrasensitive to any change in physiological parameters I tapered from 15mg to 3.75mg in a turtle’s pace: 3.75mg at a time, with more than a month (and even two sometimes) between each taper. I have a PhD in Chemistry so I know what I’m doing. Again, every time, after 2-3 victorious days where I’d feel like I’ve conquered mount Everest, I’d then feel lousy for 4-8 days; but then things would seem to be a bit better. Weirdly, at the lower doses of 7.5mg and 3.75mg I started again experiencing swallowing difficulties; I started choking on water and became very mindful of my swallowing dyscoordination. Still I felt altogether quite alright – and I believed that the remainder would be similar.
How wrong was I. I have come off it completely exactly two weeks ago. Again 2-3 days where I felt fine, then a few more days with cramps. Then, good old panic hit, with terrible anxiety that just keeps getting worse and worse. I feel terrible weakness, zero energy, I have withered due to loss of appetite (since when I eat my stomach just cramps a few hours later; actually not so bad since I had put on some weight during my time on Mirtazapine). I feel completely overwhelmed by the symptoms: every time there is something new. I feel weird tingling sensations and I have strange feelings of pressure in my stomach. I get dizzy a lot and then just feel weak. My muscles are sore without any reason. I was certain that these issues would resolve in a few days; Mirtazapine’s half-life is quite long and I know that receptors can take 2-3 weeks to get re-modulated (actually that’s why they always say that the beneficial effects of Mirtazapine will take around 2-3 weeks to become effective when you go on it). But I did not expect this gradual and horrible worsening of symptoms over the last 14 days. I have had to start treatment with Benzo’s (as needed, I try to avoid them but sometimes there’s just no way around it) and they seem to help in some instances, whereas in others they only seem to do a moderate/poor job at managing the symptoms. For the first time in my life yesterday I suffered from ED. Never happened to me before and despite a very supporting and loving wife, I felt that was yet another crushing blow. The weird thing is that all these things are not getting me depressed – just really anxious.
I can only hope that things will start to get better. I have no idea when these things would begin to get back on track. Doctors seem to be quite oblivious to my suffering, not really believing that withdrawal could be so powerful yet not finding ANYTHING else wrong. The situation is really frustrating.
One thing is clear to me: I’m never, EVER going back on this horrendous drug. It was a huge mistake beginning with it, and for all of you who need these kind of drugs: ask your GP or Psychiatrist what are the withdrawal difficulties expected for the medication. I know I sure wish I had asked it.
If anyone could share whether they’d experienced similar withdrawal symptoms and how long they’d persisted, I’d really appreciate your comments. I hope that by posting this someone else will also benefit as the internet searches are really frustrating as well.
4 likes, 536 replies
London_ridge n95192
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it's rough but once you get on the right track it isn't so bad. You'll be off this junk soon and back to work and back to being yourself. You'll feel empowered. We all can do it!
i had a small hiccup yesterday but that's all it was. Felt fine the rest of the day. Slept 10 hours last. Ite as I really needed it.💚
manuelmanuel London_ridge
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jo97038 manuelmanuel
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Can I please ask as you are so knowledgeable when I'm likely to feel better. I'm reducing 1 day a week as per CITA's tables of reduction & this week I'm upto 3 days off Mirt. Will it be 6 weeks approx after my last dose? I've had days of feeling fine & then days of extreme awfulness!! Comes & goes in waves, which CITA said it would.
Also a huge well done to Susan you're an inspiration, continue good health hun!
Thanks
Jo
susan53140 jo97038
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I'll let Manuel work it out but just know the awfulness WILL pass.... Just focus on one day at a time x
manuelmanuel jo97038
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jo97038 manuelmanuel
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I'm following the CITA reduction plan, I'm down to 0.1ml of liquid which equates to 1.5mg of tablet. I started, as they suggest, dropping a night each week of the Mirt, so this week it was Mon/Weds/fri next week I'll add another week. I've been tapering all year.
The awfulness is aching, low mood, fatigue, nausea, anxiety & then tends to be one night where I don't sleep at all. Mainly due to anxiety & nausea.
I'm starting Acupuncture tomo afternoon, never had it before but they reckon it's effective for all of the above, so fingers crossed.
Jo x
jo97038 susan53140
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How's your sleep been throughout the withdrawal process? I have patchy nights & then nights where I wake at 3am, like this morning & the knot in my stomach prevents me falling back to sleep!
Well done tho, so happy for you!
Jo xx
susan53140 jo97038
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My time lines are a bit hazy now but I think for two weeks I really struggled sleeping, at first due to just waking up at the wrong time and not being able to get off again.
If I remember rightly the first week of withdrawal wasn't so bad, I think it really kicked in on week two. Then I suffered like mad with hot and cold sweats through the night.
I would wake up absolutely freezing but drenched with sweat. Extremely unpleasant as I began to feel really unwell on top of having little and very much interrupted sleep. I think the night sweats lasted about a week at their severest and then tapered down. My son slept with me one night about three weeks in and swore never again lol.... I had thought I was ok but apparently when I slept I was all over the place. (I'm not complaining ..... He no longer feels the desire to ambush my bed 😃).
After the sweats calmed down I was totally exhausted. I would be getting ready for work and literally have to have ten minutes snooze between getting out of the bath and doing my hair. Everything and anything just depleted my energy. This lasted for the duration until the antibiotics kicked in, so it could have been a mix of withdrawal and the infection.
We need to sleep well and eat well to cope with the withdrawal, unfortunately they are the two areas which really get screwed up in the beginning which then leaves us in a vulnerable place to then face the rest of withdrawal and recovery.
I would recommend taking a good balance of vitamins to help your body cope, however, the problem I had was that I couldn't keep anything down even if I managed to swallow it.
In the end because of the swallowing issue my GP gave me liquid antibiotics. I was able to keep this down .... and I feel like they have saved my life.
So many side issues going on with this stuff but I think a comprehensive listing of possible effects could do a lot to calm others.
Remember that if you start to feel like it is something more than withdrawal it is possible you have picked up a virus or just a simple infection but because our body's is already at war, then it's resources are depleted and any infection could get a real foot hold. If you even suspect you have an infection ask your GP for a blood test as that is the only way they will be able to distinguish between withdrawals and something else as the White cell count will be high, indicative that the body is fighting an infection, or at least trying to.
Let me just say though ..... The withdrawal may be vile but it IS WORTH IT!
Also it is worth mentioning that I was really stupid in my withdrawal approach and those that are being sensible and tapering may not feel such extreme withdrawals. Hopefully!
You will get you back again and everything will seem that bit more brighter. 😀
jo97038 susan53140
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Thank you for your reply. I've had nights where I've woken up with a wet chest neck area from sweating too!
Is your sleep better now?
I'm taking Aloe Vera Gel drink daily plus, Vit D, Omega 3, 3 x a day, multi Vit & B complex too!
I'm starting Acupuncture this afternoon too! Eeek bit nervous bout it but have been told it can help with withdrawals etc. hope so! I really miss going to the gym, haven't been properly for weeks! Just too fatigued or feeling ill on & off.
We will get there, just like you!
Best wishes
Jo xx
manuelmanuel jo97038
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susan53140 jo97038
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I sleep like a baby now . It's all temporary....just keep hold of that thought x
susan53140 manuelmanuel
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Fudgeybear1 jo97038
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susan53140 Fudgeybear1
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Fudgeybear1 susan53140
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manuelmanuel Fudgeybear1
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susan53140 Fudgeybear1
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susan53140 manuelmanuel
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manuelmanuel susan53140
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jo97038 manuelmanuel
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Thank you for replying. Before 0.1ml I was tapering by dropping a dose or two each week so tapered each drop over 4-5wks more in the beginning. I dropped by 0.05ml so tiny dose but it worked fine up until I hit 0.1.5ml!!
Like I've said I'm having good days in amongst the bad, so at least there's some rest bite for me.
I've got diazepam for when anxiety is really bad, but use them sparingly. I've also got nausea tablets from GP for when it's bad, & use either ginger tea or ginger beer which does help.
I guess I'm nearly there, just hoping it won't get worse when I'm virtually off or have come off! That bit scares me.
Thanks again
manuelmanuel jo97038
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jo97038 susan53140
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Can I please ask how was your sleep before MIRT? I went on it for sleep & anxiety problems that only started last year. My GP wasn't sure which was triggering which.
I hoping my sleep will balance out once I'm
Off it. Touch wood my anxiety isn't like it was last year anymore only on off days!
Jo xx
susan53140 jo97038
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jo97038 susan53140
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Thanks again Susan. Have a great weekend, feeling well!! 😃
jo x
jo97038 manuelmanuel
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jo97038 Fudgeybear1
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susan53140 jo97038
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Concentrate on how well you are going to be feeling soon, consider every ache and pain a victory, as the drug is purged from your body, all be it kicking and screaming, it's just its death throws.
Don't worry about the reasons that took you to Mirt, don't make yourself anxious that the symptoms will come back, avoid any self fulfilling prophecy.
It's not something you can foretell, focus only on getting better. Man, if we can persevere with this level of crap .... Then getting a handle on anxiety has got to appear a much easier option. We are FAR stronger than we think we are.
Worrying will only do you harm and it really isn't worth it. Worrying is useless but having a plan is useful.
Tell yourself if any symptoms re occur then you will deal with them as and when. I told myself that if any of the nonsense started again I would look at alternate methods of management. I had a solution ready in case but I didn't worry about it at all.
All my anxiety symptoms have gone and I was on this road for around five years (stress and more stress). I feel more together now than I have in a very long time. So will you! X
margaret77657 susan53140
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manuelmanuel margaret77657
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susan53140 margaret77657
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whatever you do DONT up your dose, think GP's are confusing the WD symptoms with a need for more Mirt. Will Bob badk later, in a rush now x
manuelmanuel margaret77657
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jo97038 susan53140
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can I please ask, did you have any anxiety whilst withdrawing?