Mirtazapine Withdrawal

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Hi all, I've been on 30mg Mirtazapine for over a year and me and the doc decided I should reduce or come off them, they didn't seem to be helping me much anyway. So for the past 2.5 weeks I've been taking 15mg tablet at night. First few days were fine, then wham, it hit me I felt awful for 4 days, sick, dizzy, fuzzy head, no appetite, generally feeling unwell. This has eased off a little and I'm so nervous of cutting down to 7.5mg I'm wondering how long I should wait before doing so. I know I should speak to my doc but you guys have experience and I feel that you can give me an idea of a good time to cut back again. I'm still having funny feelings in my head and no appetite. Hoping I never have to take AD's again, my main problem is anxiety, insomnia.

Thank you, Kath rolleyes

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  • Posted

    Hi Kath,

    All I can say is that everyone is different. Some people can come off really quickly, others have to go slower.

    If you're having major WD symptoms then you could be going too quick. I went from 15 to 7.5 to 3.75 within a month and had really bad SEs so went back to 7.5.

    As much as you may want to come off mirt, a slow gradual reduction will benefit in the long run. I can only go by personal experience, if WDs are too much then going back to a dose that was manageable and reducing slower could help.

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  • Posted

    Hello Kathleen,

    I don'y think its wise to do another 50% drop as the last one was so bad.  Have a look here so at least you hve an informed choice

    For advice on tapering Mirtazapine slowly at the recommended rate of no more than 10% every 3 or 4 weeks, please see the following which is within this forum, 


    and then click on the link "REDUCING AD'S USING 10% WITHDRAWAL METHOD". 


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    • Posted

      Thank you Calmer for your advise I will take note and reduce slowly as you have advised.

      Still having problems with anxiety but will perservere. I have appointment on Friday to see a Counsellor so I can only hope it helps without staying on AD's.



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  • Posted

    Hi Kath....you are being really sensible at your approach to reducing the mirtazapin and working with your doctor to achieve this.

    I've been on 45mg mirtazapin for 9 years, 800mg quetiapine, zopiclone, venoflaxine amitriptyline and way to much diazepam. (I have bipolar, pschpsis anxiety depression. I went total cold turkey (silly I know) mainly because of weight gain. Nearly 8 weeks into it but although it's been very hard I have coped and lost almost 2 stone in weight. I actually feel happier at the weight loss, more confident, less depressed and have only experienced 1 psychotic episode since stopping.

    I think if you apply yourself mentally you can do it. Stay strong....you will get there

    Kindest regards

    Jeannie. X

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    • Posted

      Thank you for your advise I'm still taking 15mg (this is my third week),very dubious about reducing again just yet as I'm still having some withdrawal symptoms. At least that's what I hope they are! Headachy, stomach ache, general feeling of being off if you know what I mean.

      I'm thinking I won't be able to judge the dose correctly cutting down a 30 mg tablet, I don't think my doc would give me the liquid form. Any suggestions please?

      Thanks to all for your kind replies.

      Kath x


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    • Posted

      Thank you Calmer your a real gem. ?I've been on 15mg for 3 weeks should/can these horrible feelings especially stomach upset, and achy linger this long? I'm wondering should I go back to my doc to see if he can help. I also have high iron levels and waiting for tests so wondering if this is contributing to me feeling so unwell.

      But I will take the reductions very slowly.


      Kath cry


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