Mirtazapine withdrawal, how long does it last?

Posted , 179 users are following.

Hi, Just looking for some reassurance/support. I was on mirtazapine for about 6months. I went up to 45mg and decided to taper down as I felt they were making me worse and the weight gain was nasty. I felt fab tapering down and generally, its been better than I anticipated however, I'm approaching the 3rd week off of mirtazapine and have started to feel a bit anxious the last few days. I've read withdrawal peaks around the 3/4week mark, so I'm trying to stay positive that it will pass.

15 likes, 803 replies

803 Replies

Prev Next
  • Posted

    Am I the only one who’s anxiety makes them afraid of anything and everything? I have anxiety all day long every single day, but sometimes it lessens just a bit in the evening. 

    Anyone else?

    • Posted

      Hi Jo, I am afraid all day long. The evenings are better only because I am not alone. A fear driven life really stinks. I hope it goes away...for all who experience this.
    • Posted

      Jo I've been afraid of going in the bathroom on many occasions etc, totally irrational also have racing thoughts and crazy fear x

    • Posted

      I’m really sorry you have fear all day long too, Gretel.

      I don’t know how I’m going to survive this. I can barely function, . Between the constant negative & intrusive thoughts and the non-stop anxiety/panic/fear I’m not able to do anything but sit on the couch frozen afraid to do anything. 

    • Posted

      Toria, so irrational. I’m amazed at what my brain remembers in order to make me afraid of things and situations. It uses all those memories against me to make me feel fear. 

      I wake up feeling like this every morning now. I remember before mirtz how I always woke up feeling content and NORMAL. This is NOT normal. 

      It’s so damn hard to do anything, I have to plan exactly how I’m going to do the smallest task because of the fear. I feel so overwhelmed by everything. I look around my house and wonder how I was able to do things before this. I effing hate this!!

    • Posted

      My partner goes back to work on Monday I've not been alone since I went into hospital august the 13th, it's madness as the day before that I was wandering around a golf course with my partner without a care in the world, I want my life back 😭 X

    • Posted

      Do you have any physical symptoms jo?
    • Posted

      Yes, I do. Loud swishing in my ears, internal tremoring, racing pounding heart & cold sweats to name  a few. 

    • Posted

      I’m also starting to have brain zaps. Feels like someone is slowly parting my scalp. 
    • Posted

      What are you going to do to prepare yourself for the 13th, Toria? 

      You can do things to make the transition easier for yourself.  Like maybe your partner can FaceTime with you during your time alone.

    • Posted

      I'm freezing all the time until bedtime and then it calms a little, my partner is going to ring me and try and pop home for lunch, it's crazy as I used to like my own company, strangely though even through all this I'm ok going in shops alone but that might be because I had CBT years ago who knows x

    • Posted

      Yes, since mirtazapine i am afraid of everything, so stupid as i wasnt like that before.  I cant sit in dentists chair, i cant sit to get my hair done which should be a pleasure, i dont like to go out alone, i cant even go for a massage which should be relaxing.  So many other things.  What has this drug done to me, ive lost my confidence to do anything.   Youre not alone, many in here have the problem, i wish i knew the answer to get my life back.
    • Posted

      I’m also noticing that when I get too hot if the room temp is up it spawns a panic attack. My heart races, I get full body sweats etc. 

      Anyone else sensitive to heat causing anxiety/panic?

    • Posted

      I very rarely get too hot I'm more the other way, although when I am overheated I feel anxious and like I can't breathe also the first two times I quit mirtazapine I had sweaty hands feet and armpits for quite some time (nice) 😦

    • Posted

      Toria, you can do this. I know how hard things are, even the simplest things we use to do are a big deal and scary. But you’ve got this. The dentist is going to tell you everything looks great. Tell yoyrself going to the dentist is taking good care of yourself. It’s a very positive thing. 
    • Posted

      Thanks jo 😘 I never used to think twice about things like I do now, it's like my thought patterns are in a constant vicious circle x

    • Posted

      Nor did I, Toria. I have been notoriously independent my entire life, now I’m a frightened needy mess. 

      I think the mirtz reduction/withdrawal causes our bodies to release cortisol which creates all this fear and anxiety/panic.  How can one combat a chemical that I’m taking every single night. This weaning takes forever. How will I outlast it? 

    • Posted

      I’ve also had CBT and DBT. Isn’t helping me much that I can tell with tapering.  
    • Posted

      How's your eating jo? Also things I find that help are a walk each day (not in the morning as makes me more anxious) plenty of water, Epsom salts in a bath as they contain magnesium which helps with anxiety and as you get lower on mirtazapine avoid histamine rich foods as that's what makes you itch, if you have trouble sleeping buy some anti histamines as that's what's in mirtazapine and that's why when you withdraw you get allergies and rashes etc, the lower doses are more sedating too x

    • Posted

      My eating is very bad. I’m trying but it’s so hard since I’m afraid of everything. 

      What are histamine rich foods? Can you name a couple examples?

    • Posted

      Spinach is one, but you won't need to think about that until you're off mirtazapine, try not to be scared, I've found chicken makes me feel a little better I've also been cooking from scratch x

    • Posted

      Thank you, Toria.

      I don’t have any issues with being itchy or rashes or anything. The first time I tried to wean off in 2015 I did though, but that’s when I weaned off a quarter of the dose every 10d. I was off 15mg in the matter of a month. WAAAAAAY too fast. 

    • Posted

      Mirtz has never made me drowsy or sleepy, just the opposite. It wires me, which I told the provider back then and he ignored. I told him my body can typically react opposite compared to most people when taking stuff. 
    • Posted

      I’m reading apples and onions are loaded with anti- histamine properties. 

      Thank you for all the good tips. Toria.

    • Posted

      I am not even off it yet, have managed cown to 3.75 and will try anothrr cut soon but im very sceptical it will help me feel better, everyone here seems to be much worse off it.
    • Posted

      Try to stay positive, Ann. The slower you go, the better. 

      It’s probably true that even after your last dose there may be residual side effects for a while but I think/hope they would not be “as bad” as if you had just stopped taking it at 3.75mg. 

      This drug is nasty and very hard to understand why it lasts and impacts your system for so damn long.  Someone would make a boat load of money if they figured it out and sold a mirtz withdrawal kit. It would literally save lives.

    • Posted

      BTW Ann, congrats on being on 3.75mg!!! Thats huge progress. Stay strong. 

      I’m right behind you at 10.5, and in just 1+ week i’ll be moving down to 9mg. Gulp. 

    • Posted

      Well done to you, progress indeed.  Keep posting and we will see what comes next.. for me its diazepam as im now tolerant to 5mg so that is another taper to,come!
    • Posted

      Hi Ann, you are almost there. You are a real trooper. It seems like some are symptomatic after w/d, but then there are those who hop off without troubles. Just stay positive, i found tha t helped alot.

Report or request deletion

Thanks for your help!

We want the community to be a useful resource for our users but it is important to remember that the community are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the community is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.