Mirtazapine withdrawal, how long will this last??!!!!

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Help! I slowly tapered off Mirtazapine. It's been 4 and a half weeks off it now and I'm sure I'm still experiencing withdrawal?! I have crippling morning anxiety and zero appetite, the weight gained on Mirt has fallen off! I also feel sick most of the day. I got so down last week that I very nearly went back on it, but couldn't bare the thought of coming off again! Insomnia has just kicked in too. 

I don't mean to post this to scare anyone, as when I was at my darkest Mirt really helped me. I just wanted to know if there's anyone out there going through what I'm going through? Any advice? How long can it last? 

I'd appreciate any help x 

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  • Posted

    Hi there,

    I'm so sorry you're having symptoms still. Do not go back on the Remeron. It will defeat all the hard work you accomplished to get off of it. I'm still struggling with my withdrawal but I'm focusing hard on my diet even though I'm nauseous and I'm pushing through to exercise and take vitamin supplements. I have Xanax on board when I am too anxious. You're almost at the finish line. Don't give up! Drink lots of water, try to remain calm, eat healthy meals and get plenty of exercise to sweat out the poison in your body. I promise it will help your mental state tremendously. I've read that withdrawals can go on for weeks to months and I'm determined to do whatever I can to survive this and look back and say I will never be that drugged depressed overweight woman again. Stay strong and fight to get your life back. 

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    • Posted

      I am still trying to lower this mirtaz.  I have to admit i went back to 7.5 one night as the insomnia at 3.75 and nausea was awful. I have stabilised a bit now on 5mg but very wary of lowering.  Will i just get the insomnia again on 3.75? Have you any hints on how long it will last before stabilising again?   The nausea is not great but im managing it with buccastem when needed.

      i will have to do another tapering of diazepam of 5mg when the mirtaz is gone.  I have read that this is easier than mirtaz one which is likened to heroin withdrawal.

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    • Posted

      Hi Kirsty 

      I promised myself I wouldn’t do this and look for reassurance but here I am !

      I weaned off Sertraline several weeks ago and have now weaned off Mirtazapine, I took my last dose (3.75mg) 6 nights ago , I was doing ok but the last three days have been a challenge! Very tearful and anxiety nipping at my heals , I take 2.5mg of Diazipam first thing in the morning and last thing at night as advised by the neurologist.

      You are well into recovery now going by your last post , I was wondering how you’re doing and when did you start to feel some relief.

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  • Posted

    Thank you! May I ask how long you've been off it for now? And do you still get spikes in anxiety? Insomnia seems to be kicking in now too. Crikey this med has some rebound effects doesn't it?! 

    I'm trying with my diet, but it's so hard when I feel so sick. I will up my water though! I try and get out every day, as my thoughts are racing! All this and looking after two little ones. Thank you so much for getting back to me! 

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    • Posted

      I've been tapering for only a week now after being on for 4 years. I've ended up on the ground many times now screaming in agony and my family has been terrified and keeps wanting to call 911, but when I feel the storm coming on, I take a beta blocker for my heart and a xanax for the anxiety it's giving me and just have to ride the storm. This medication should be banned. I feel as if I was coming off of heroin. I have kids also and a full time job and it's been unbearable. The only thing helping at this point is the diet and exercise and knowing my body is finally getting used to the taper. My mood is so much better also. I'm struggling with insomnia so I am taking Benadryl to help with that. Remember that every antidepressant will be addicting and have horrendous side effects. Isn't it crazy that the one thing that is supposed to help is the one thing that destroys you in the end. 

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    • Posted

      Do you get the anxiety in waves? That's exactly how it feels for me! I was in shock by how long this med takes to come out of your system. And the sickness is driving me mad, I feel pregnant, when I absolutely am not!! 

      I asked my doctor about betablockers but he wouldn't prescribe any as said they were too addictive, but will give this out no problem! A few times I have actually felt this is what it must feel like go come off heroin, it's crippling isn't it! 

      Surely it can't be much longer, I want this stuff out of my system! Hate waking up feeling awful, that's the worst time for me. 

      I wouldn't even have though of Benadryl, does it help?

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    • Posted

      There are a few of us who are experiencing the same symptoms as you with Mirtazapine withdrawal on the " Escitilopram and Mirtazapine " thread .

      We have all had the same problems with withdrawal.

      Yes the anxiety does come in waves.

      Are you replacing the Mirtazapine with another drug or withdrawing from antidepressants altogether?

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    • Posted

      Withdrawing all together, I've done a very slow taper, hoping that would help, but it's hit me hard. I've read that at 4 weeks a lot of people struggle? Any help and advice would be most appreciated 😊

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    • Posted

      Yes, you and me too.  Slow taper is hitting me hard, down to 5mg now. Anxiety still there. Dr gave me diazepam to help it. Works a bit.  I am doing same as you, trying to withdraw altogether but its hard.  Have you been having the nightmares I get? I am coming up to four weeks after the last drop so its not easy.  I am also looking for advice and help.  I am on warfarin so cannot take omega3 fish oils but thats meant to help, also magnesium.  Most herbals are out for me due to interactions.

      do you use diazepam to help you? I know people say go to a class on meditation or yoga, the anxiety is stopping me and i feel so inadequate.

      look forward to hearing about you today.

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    • Posted

      Oh Ann,

      Please don't feel inadequate, I can't face going to places either!

      I think it's another symptom of withdrawing from this drug?

      God it's hell thats for sure!

      Hugs 🤗 

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    • Posted

      Hi Ann,  I'm so sorry you're going through all this too. I'm not 4.5 weeks off Mirt completely.  But it's tough, I'm not going to sugarcoat it. I'm not sure how much you'd like to know, as I know sometimes knowing too much can be worse for us? I'm happy to share my experience if you'd like warts and all though? Right now I have waves and peaks of severe anxiety, especially morning times and in the middle of the night. I'm sure this must go away though?? 

      I'm not taking anything else at present, doctor was reluctant to give me anything other than an antidepressant and I didn't really want that! He wouldn't give me betablockers for when I'm really struggling either, clearly never been on blooming Mirt 😂

      Happy to answer anything I can help you with 😘

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    • Posted

      I think i am having the similar experiences of those reporting on here.  Did you taper off at 7.5? Nausea some days, insomnia, anxiety, some days worse than others, appetite changes, a bit of agoraphobia but trying to push through it.  The nightmares are the worst.  Someone messing with my brain.  Some days s. Ideation.  I do find diazepam helpful 2mg.

      yes, warts and all - at least i will know its not just me!

      i am not taking any other anti dep and really dont want dr to try another, they've all given me problems.

      hoping you can push on through today, good wishes.

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    • Posted

      hi again Karen,

      are you completely off now, sorry i get mixed up about who is where.

      am i the only one with the nightmares?

      pity we cant get together and thrash out all our problems!  Although you wouldnt want to go out here its like a monsoon rainstorm!

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    • Posted

      Hi Ann,

      Yes I'm off Mirtazapine altogether now, been about 3.5 weeks, though it seems longer!

      Am now on 10mg Escitilopram, which I'm on day 21 of along with Quetiapine and 2mg Diazepam.

      I had the awful nightmares on Mirtazapine, but they have now appeared to of stopped.

      Hope things improve soon.

      Hugs 🤗 

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    • Posted

      It is different to tell to be honest with being on Quetiapine too.

      I started out ok on Mirtazapine so I'm not sure if things will stabilise on Escitilopram or get worse like they did with Mirtazapine!

       It then it only got bad on Mirtazapine when the dose was increased!

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    • Posted

      I get anxiety in waves. I can get full blown panic attacks and feel like I'm having a heart attack. That's the only reason I'm taking the beta blocker right now because I wonder if I will even survive this mess.  

      The Benadryl helps a lot with sleep and with the insane headaches I'm getting.

      Wish there was an easier and faster way to be done with it.

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    • Posted

      Hi! 

      I tapered right down to 1.87mg for two weeks before coming off completely. 

      It's been really hard (still is) first 10 days felt fine, then had a Sunday where it hit me, couldn't sit still, tremors, complete anxiety all day long, couldn't eat, I was a mess! 

      One day not so bad, then one day awful. I'm still waking up with severe anxiety every morning, I have to wait for it to calm down a bit, that's tough too. I still have really vivid dreams, thought they'd have gone by now? 

      Appetite is rubbish, I have to force myself to eat anything, so all the Mirt weight I put on is well and truly gone! 

      I'm truly hoping I'm getting to the end of this, I don't want to scare anyone by writing what I have, but it's my honest account, I could never have imagined it would be this tough to come off a medication. I'm hoping I can keep going!! 

      Anything else I can help with, let me know x 

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    • Posted

      I tried to find Benadryl today, and nowhere I live stock it! I get panics likes that too. Just awful, I never had palpitations as bad before! I've started getting awful headaches as well, didn't think they would be connected to the withdrawal, but it makes sense. It's been the longest 4.5 weeks of my life!!!!

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    • Posted

      I'm so sorry! I would suggest ordering it online if it isn't anywhere close by. I can't find anything that helps my headaches but ibuprofen and Benadryl together. Let me know if you need help in finding it. I'm a drowned rat at work right now so today should be awesome. 😝

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    • Posted

      I live in Idaho. It's about 75 degrees right now and the sun is out but I am sweating from the good ole Remeron. I feel like there should be a class action lawsuit against them.

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    • Posted

      I wake up sweating like a pig, never thought it was that either. God the list goes on doesn't it!! 

      I'm in Oxford, England, we don't get many sunny days 😂

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    • Posted

      Hi Kirsty.  I am not feeling so good again today, broken sleep, quite depressed and just generally rubbish.  The thought of another day.

      i am not even at the 1.87 yet, still at 3.75 and bad enough.   Things seem so much worse i even thought about going back up a dose but as these have never really worked for me it seems futile.

      did your gp send you to see psychiatrist or are you under gp alone.  I have been seeing psychiatrist since things got bad.  All he does is try another anti dep and then it doesnt work and im back to square one.   He has tried to get the mirtaz up but larger doses i couldnt cope with. I am in such a quandary as upping doesnt work, lowering is making me feel down and anxious , and changing doesnt seem to work.  Did you actually feel better on mirtaz and it did its job before you lowered?  I have never got to that point. 

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    • Posted

      My GP wanted to send me to a psychiatrist, but I refused. I'm under his care but I don't think he fully understands how hard it is to come off this medication so I've relied mostly on reading materials online and joining this forum. I never responded to any medication out of numerous but the Remeron, but the more dosage I took, the worse I felt. Everyday was pure hell with depression, weight gain, headaches, anxiety, not wanting to go anywhere, suicidal thoughts, you name it. Since I've been tapering off of it, I have many withdrawal symptoms but I do not feel depressed like I did and I don't have suicidal thoughts and the night terrors are gone. For me personally I will never go back on any psych medication again. Are you maybe wanting to switch to a different medication or are you wanting to be done completely? I know the only thing that has truly helped me cope with this is diet and exercise and plenty of water. I do have to force myself to go for walks but I feel so much better afterwards. I also take Benadryl to help me sleep at night which generally works wonders. 

      Keep me updated on what's going on.

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    • Posted

      Hi Ann, I'm so sorry you're struggling today. How long were you on Mirt before you cut down? Mirt did help me, it helped me sleep and helped with my anxiety. 

      I didn't find the reduction hit me as quickly as it has done for you. But I completely sympathise. 

      I'm only under the doctor. I've got talking space CBT over the phone, but it's not enough to be honest. 

      Can you get a doctors appointment? The most I could go up to was 15mg Mirt. 

      Here for you xx

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    • Posted

      I have had a bad night.  I am not sure if its the lowering mirtaz causing the symptoms, or if its the original symptoms coming back.  People say keep trying to lower but its so uncomfortable.  Now i dont know whether im ill again or if its the med causing it.  I was find becore the merry go round of meds started to try to control my anxiety.
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    • Posted

      Hi Ann,

      I keep having bad nights too just when I think I'm starting to be fine and taper down to the next lower dose. Anxiety and chest pain and insomnia ugh. Worries me for when I taper next on Monday. Not sure exactly what is causing it but I understand where you're coming from. It has to get easier I hope! 

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    • Posted

      Hi, well this taper is not going to,plan.  Three weeks down to about 3.75 and horrendous nausea, anxiety and insomnia.  Together with depression and feel like im going mad.  Brain just not functioning.

      Last night had to resort to the 7.5 as i woke with anxiety attack after a day of nausea.  Dont know what to do next, think i will have to start back nearer 7.5 and drop more slowly, hope that will work for sleep and nausea.  Hips ache too, seems thats also a side effect.

      is benadryl available in uk over the counter, that might help the insomnia, not the anxiety though.

       Any useful tips appreciated.

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    • Posted

      Hi karen

      I see from your last post a month ago that you are now off mirtazipine,was wondering what dose you had been on at start? for how long? and how did you taper off? and your experiences of withdrawing from it?

      was wondering why you came off this drug? and how do you feel now you have been off the drug a bit longer,have all side effects gone? and how long have you been off it now?

      really hope you are doing well

      chrissy

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    • Posted

      Hi karen

      Hope you continue to do well,how long have you now been completely mirtazipine free? Have been reducing from 45mg since May,and currently at 18.75mg,and looked many suffered the withdrawel nausea,extreme fatigue,tinnitus,sweats and anxiety spikes along the way,but taking it slow and getting there.Had been on 45mg nearly six years which really helped my severe clinical depression at the time,would have been prepared to remain on this drug for ever,even put up with weight gain,but the nightmares have become unbearable.still having them even while reducing,but see this is quite common too.just wanted to ask at what stage did your nightmares completely go away? And what was your dose you started on? And by how much did you drop each time?

      Best wishes that you remain sell.

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    • Posted

      When I went off the worst for me was early mornings. It was like pure panic and I never had much anxiety before mirtazapine. I wish you luck and stay off it. 

      I went back on and now I have no idea what to do..help ! 

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    • Posted

      I’m sorry you are experiencing this but can we stop with the heroin analogy? Having come off both stopping mirtazapine is nothing like stopping heroin. The former is a thousand times easier and people reading this who might be depressed and needing mirtazapine could be put off by the comparison. 

      My understanding is that mirtazapine is an antidepressant primarily and that if the depression is effectively treated and not chronic or recurrent in nature then when one comes of the drug there should be few problems aside from mild insomnia, which was my experience. But doctors use mirtazapine for anxiety and insomnia but, unlike depression, it only treats the symptoms whilst one is on the drug so if you were anxious and had insomnia before mirtazapine then it is normal that these would come back unless you have done some psychological work (anxiety management, CBT, mindfulness meditation etc.).  

      Everyone’s brain and body are different though, as well as the way we metabolise meds, so obviously I can’t speak specifically to your situation, but ask yourself if anxiety and insomnia were present before mirtazapine and, if so, try stop blaming the drug for ‘withdrawal’ symptoms and try and find non-pharmacological methods to deal with your anxiety, if that’s what you want. 

      I hope this isn’t too unsympathetic - I have struggled with depression and anxiety for years so I understand. Interestingy, I’m free from both for the first time in my life (off meditation) after trying ayahuasca five months ago. It’s a potent 5HT2a (serotonin) receptor agonist so there is a scientific reason why it would work as an antidepressant/anxiolytic but, obviously, it’s a psychedelic drug so it wouldn’t be for everyone and one has to be off all psych meds beforehand as there can be a dangerous interaction between the plant and, in particular, antidepressants. Also, if there is a history of psychosis or bipolar disorder in oneself or one’s family one should avoid it.  Put “Prof. David Nutt, psychedelic drugs and depression” into YouTube and watch his talks on the topic. 

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    • Posted

      There is a Facebook page dedicated to the withdrawals of mirtazapine seriously have a look some horrible story’s I was lucky and did suffer to bad but have gone on lovan a antidepressant because of my fibromyalgia I read some pretty horrible stories I went off of the page because sometimes the more you read the more you think about it and the worse it feels I never had any side effects except the slight weight gain but that came of every one is different some people don’t suffer at all and some do really badly you’ll be ok just hang in there it will pass❤️
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    • Posted

      You could always try another antidepressant I did and it helped me heaps then cane of that easy I’m taking a low dose antidepressant called lovan but that’s because I have fibromyalgia Valiums helped me heaps while going through the WD ❤️
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    • Posted

      Hello Pierre

      I think you might want to do a bit more research on the % of people who do indeed experience very severe acute long lasting withdrawal from mirtazapine. Your experience is one person’s story, and fortunately you’re one of the lucky ones who did not experience its withdrawals. 

      I have been reading and researching mirtazapine for over 3 years, thousands of stories, hundreds of sites. A very large percentage of people do experience crippling long lasting withdrawal rivalring heroin withdrawal from this rogue unstable drug, both physical and psychological, regardless of how long they’ve been on it or for reasons why they were prescribed it. And BTW, many are preschbed it solely for sleep, a widely prescribed off label use. So those folks never had anxiety or depression or any of the horrific w/d symptoms mirtazapine unpacks on them before taking it.

      Maybe try and learn about others stories instead of solely relying on your experince as the one and only sample of what is real world.

      I wish you well.

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