Mirtazapine Withdrawal- the key to success

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In a month I will have come off mirtazapine completely and for some of that time I have been able to work and do my job pretty darn well.

I went on mirtazipine for anxiety and it did not work and I put on 1 stone in weight was drowsy all the time and generally doped out. In some ways it was actually causing more anxiety and depression as well. Withdrawing from mirtazapine is different for every person and everyone has to go at their own pace. For me, it was extremely slowly when I got down to 7.5mg and lower. The tablets don't allow you to do this so request the mirtazapine solution that you dispense with a 1ml syringe into a little bit of water every night. Going cold turkey is a terrifying experience, the one most awful experience of my life and its also dangerous. I do not agree with people advocating taking valium during the withdrawal process because for anxious or depressed people a drug that powerful leaves you vulnerable to addiction because speaking from personal experience that is exactly what happened to me. Valium in my experience is nowhere near as hard to withdraw from than mirtazipine because it is so short term whereas the mirtazipine is a long drawn out business making it hard to lose perspective on what is a withdrawal symptom and what is your underlying problem. I kept a diary of my symptoms so I could look objectively at what I was experiencing and sort it out, but I still forget sometimes. As I said earlier about some of the time I have been able to work Im talking about the past 6 months where I have been following a plan devised by myself that works if you find the quicker withdrawals like \"half a table for a week then nothing\" or cold turkey dont work. There is a website by the organisation called CITA (google it) and they have a Back To Life handbook that you pay £13 for and it gives you a specific plan for mirtazipine withdrawal, tells you supplements to take such as the powerful detox drink Noni Juice, how to alter your diet to help decrease withdrawal symptoms. I had my vitamins tested and whereas before the process I was fine, afterwards I had a chromium deficiency making me very sensitive to sugar. If you can hack it I have found that a low carb, low sweetner, low sugar diet like the Atkins or the Dukan diet work very well as the mirtazipine plays around with your blood sugar levels and therefore makes you even more unstable. My basic way of withdrawing was this:

Ill use the drop from 0.1ml to 0ml (of syringe solution which with the 7.5mg solution equates to about 0.75mg very very tiny!!) as an example because that is what I am doing right now:

Week 1, take 0.1ml apart from wednesday when you take nothing

Week 2, take 0.1ml apart from monday and wednesday \"\"\"

Week 3, take 0.1ml apart from monday, wednesday and friday \"\"\"

Week 4, take 0.1ml apart from monday, wednesday, friday and sunday

Week 5, take 0.1ml apart from monday, tuesday, wednesday, friday and saturday (only take 1ml on thursday and sunday)

Week 6, take 0.1ml only on thursday.

week 7 , take nothing!

So each week you are cutting out one day of the week's dose which I have found really suits mirtazapine because if you just drop down a dose the withdrawal hits you really hard 2 weeks after and by 3 weeks on the dose I was horrifically depressed. If its too fast you can do the week 1 pattern for 2 weeks etc which I did for a while. I do see what they mean about mirtazapine having a short half life because it does hit you in the face at the 3 weeks marker, it is as if it just leaves the body very quickly between 2 and 3 weeks of dropping a dose. The gradual withdrawal that I ended up doing I think really suits mirtazipine because of this aspect.

The drop downs I did was, 30mg, 15mg, 7.5mg (half a tablet) (with the tablets I simply dropped the dose again when the withdrawal symptoms subsided) this bit was debilitating and I do not advocate it. Use the plan set out in the Back To Life booklet instead. When I tried to go to nothing from 7.5 then I experienced absolute horribleness. So I switched to solution and did 1ml (7.5mg), 0.9ml, 0.8ml, 0.7ml, 0.6ml etc etc down to 0.1ml which Im doing now. I got the solution from my GP so it is not hard to obtain it in the UK, it costs the same as a regular prescription, i think it is available in America aswell but im not too sure.

Finally i will just outline my withdrawal symptoms: vivid dreams, disrupted sleep/over-sleeping (I did a test using SleepCycle, an app for the iPhone to test whether a small dose of mirtazipine could affect my sleeping and I found with the analysis tool that I had much less deep sleep and was much more easily disturbed to being fully awake during the night than when I didnt take any mirtazipine. I think this is why you oversleep on mirtazipine.) Paranoia, itching skin, body shocks (like tingles that run from the top of your head to your toes), headaches, fatigue, bruxism or teeth grinding (can make my jaw ache), depression, anxiety, nausea, burning mouth syndrome (like a numb tingling in your tongue), floating sensations when going to sleep, cravings for sugar and carbs, confusion, forgetfulness, angry outbursts, irritability, hot/cold flashes, insomnia (the most disturbing for me but on my really slow plan I dont get this problem at all), social withdrawal (probably because my emotions were so erratic i was embarassed for anyone to see me), body aching especially in my back where I hold most of my tension, sensitivity to noise and light, blurred vision.

Some more tips: People often fear it is their illness coming back when they are experiencing withdrawal symptoms, this was not true for me because as I am nearly off mirtazipine now it is the best I have felt since I started taking antidepressants. They are only supposed to be used short term but I ended up on them for 6 years. If you felt no effect with the antidepressants after a few months it is best to come off them. Dont even risk it with drinking alcohol, it makes the withdrawal even worse, your body is going through a lot and it needs as little rubbish to deal with as possible. If you feel a burst of energy as I have done during this process even if it is 9pm go for a jog. Dont just sit around waiting for it to turn into a panic attack. And finally go with the flow and remember its not real and only temporary. \"This too shall pass.\" So just do your best at real life and hibernate through it all. This drug is not easy to come off just as all antidepressants are hard to come off, it has been compared to heroin withdrawal and having researched heroin withdrawal I agree with the comparison. If you drop too suddenly and end up seeing the doctor because you are suicidal and at your wits end you must slow down and dont let them just pump you back up to 30mg, just go back up to the last dose you took before you went crazy and go slower next time. A word of warning: the majority of GPs and doctors do not understand antidepressant withdrawal and from my experience neither do psychiatrists fully, they just prescribe. However you must not blame them for their ignorance even though it is hard not to when you are in hell, you put the drugs in your mouth so YOU have to get yourself rid of them at YOUR pace. It is sadly the ways things are in the UK at the moment.

The best of luck to anyone who is on this road.

I hope something I said in there helped you.

If it didn't nothing lost!

Kathryn.

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  • Posted

    Hi all,

    I've been reading the mirt wd posts on this forum looking for answers how to get off this nasty drug ,safely and soon.

    Briefly,I've been fortunate to be mostly healthy most of my life,

    and avoided getting in the "system" of dr.s and pharma meds..

    One year ago,I was a healthy lad.

    Then life came along,big stress,not sleeping, and the brilliant dr.s started me on benzo's..nada help...trazadone,made it worse, tachacardia side effects.,so I weened off that...months of taking this trash, and little relief...took a huge toll physically,appearance,and emotionally.

    Since early July, I've been on 30mg of mirt ED.

    It has  helped with sleep, but the trade off of the side effects are just intolerable;

    tiredness,angy outbursts,over sleeping,brain fog ,morning sweats,paranoia even.

    This is NOT me!

    After reading the torture some of you have/are going through withdrawing

    from mirt and my experience with the sides,

    I want off this drug safely, while it's still early at two and a half months.

    I had GP dispense a new rx for 15mg daily tabs,

    so I could have the ability to ween in increments.

    My  impression from reading your experiences is that even at this early stage,

    it may not be that simple.?

    I'll keep reading and learning from all of you,and I'm asking for any guidance you may have...I am trying to curb my anger at these dr.s for 

    Prescribing drugs they don't even understand how they work,

    and also how much  this has impacted my life...

    I promise my reply's will be shorter than this initial post.

    May blessings of newfound health and healing be given to you all.

    Thank you

     

  • Posted

    I wonder....How was changing to oral solution? Some people do not suggest it due to its different metabolization...
    • Posted

      Hi Manuel

      I broke the pills down from 15mg to 7.5mg got a pill cutter & got down to quarters, then nothing you can do but get liquid as the pharmaceutical companies don't make smaller pills so you can easily cut down. I'm sure they just make it harder for anyone to try to come off these wretched pills & the liquid version is very expensive so doctors are reluctant to prescribe it for long.  

      I think the medical profession & us patients should put more pressure on these multi billion dollar pharmaceutical companies to actually research into how to get people off these antidepressants & SSRI's safely and at least make the pills in small amounts so you can ween off gradually .... But of course that's not in their interest is it!

      Let us know how you get on, best of luck

      Pat

    • Posted

      They make it difficult. May be I'm ging to file a lawsuit against the german company that produces Mirtazapine (I'm an italian who lives in Germany) Unless they come back to me with a pill I can easily divide into 10 parts. Looking like a junky trying to cut the pill in tiny proportions in front of my wife is not something nice. They gave me this thing to help me sleep. And it helped, but I want to get off it because of its side effects. I could never imagine I coul feel so tired and spaced out. Im also thinking that as soon as I'm out of this situation I'm going to make a movie about it, since I'm also a film director. Just to raise some awareness, people cannot suffer like this.
    • Posted

      Good idea Manuel, we need to raise awareness of this problem, lobby the politicians, government has to do something, doctors need to be more careful just handing these pills out, it's all about keeping us hooked on medication, trapped forever taking pills we can't get off of easily.  It's just making these companies rich, the suffering people go through trying to break free of these drugs is terrible. I often wonder when I hear of a suicide or violent attack on someone how many of these people were on these mind drugs, they just seem to make any problem or obsession you had before10 times worse, not better. 
    • Posted

      Manuel same thing here.My GP gave it to me for sleep,and the sides you mentioned are just draining and complicate your ability to function properly.

      The Dr.s are playing with our lives here,it's absurd and really an abuse of power.I've only been on mirt for under 3 mos..,I just started the ween from 30mg,and taking as many cues as I can from people like yourself that are trying to get clear of this miserable drug.I wish your success in this and your health.

    • Posted

      Jumping from 30 to 15 does not seem difficult. You have to be careful from 10mg downwards.
  • Posted

    Hi Kathryn,

    Thank you for your post. It has been a great help.

  • Posted

    Thank you Kathryn, although the post was a while ago it's very relevant and contains some encouraging advice.  I'm on the road, taking a quarter of a tablet and when I reduce further I will use the syringe method which worked for me before. (I was Mirtazapine free for three years).

    My GP wouldn't give me the liquid form so I dissolved a tablet in water and sucked up increasingly smaller amounts.

    I'll refer to your post for a plan of action.

  • Posted

    Dear Kathryn,

    I'm currently living in my father's house in the woods as I've been debilitated by the fact that I tried to get off my meds' final dose (Lexapro). Then I got back on a 1/4 dose which was all my gut coul handle (gave me diarrhea and incontinence 2 years into using it and it also stopped working properly).

    My psychatrists tried Cymbalta which I had to quit after 10 days as it was driving me nuts. Then I suggested Remeron to him which he agreed to. After 6 weeks of that, it was apparent that all it did was knock me out.

    So, he got me to taper from 45mg to 30mg in 4 days, 30mg to 22.5 for 2 days and finally 22.5mg to 15mg which is where I went loopy for the following 5 days - not able to sit still, very nervous, etc. I panicked and went back up to 30mg (against your advice, I know) and am now looking at how to taper.

    My father's going to our pharmacist tomorrow who is preparing a Remeron solution from crushed tablets in 2mg and 3mg capsules. I want to get off this crap as quickly as possible but also realise that keeping an even pace is important.

    My starting plan is (once I've stablisied on the 30mg which for some reason is causing sleep disturbance) to take 3/4 of my 30mg tablet, making it 22.5mg along with two 2mg capsules, bringing the total to 26.5mg (this will be roughly a 10% reduction of the current 30mg dose) for a week. For every week following that, I plan to reduce by 3mg until either I notice some discomfort or hit the 15mg dose where I plan to reduce by 2mg.

    Do you think this a solid plan? Do you think it may be too slow or fast at any point? Are there any suggestions you wish to provide? I'm pretty terrified of your heroin analogy and hope it isn't that bad for me as I've already been hanging by a thread for a long time.

    Thanks in advance,

    Baret

    • Posted

      Yes its hard comming off mirt I have been back on it for 3 weeks at 7.5 I hate hate hate this drug im biting the bullet and cutting the 7.5 in half tonite for 1 week then get off ny 10th of june it makes me crazy im on a low doze of seroqual so I hope that helps me once om off mirtazipine then I can dropp off seroqual ...but if seroqual goes ok I my stay with that but never again remeron its so deadly anziety anziety crashes you dont go on it long term and get off it like me I know im doing it quickly but I wont have muscles ach joint psin gastro problem just to name a few

      I hope your successful

      Regatds tracy message me any time

    • Posted

      I have been very slowly reducing my dose of Mirtazapine from 15mg since January 2014.  

      Jan. I reduced to 3/4

      March,  1/2

      June, 1/4

      Had a setback in August and increased to 1/2 again.

      September, back to 1/4

      Stayed on this (3.75mg) 'till Feb 2015 when I reduced by dissolving a 15mg tablet in 15ml of water and sucking up 3ml in a syringe, giving myself a 3mg dose.

      Stayed on this for five weeks.  No ill effects so reduced to 2mg.

      After five weeks reduced to 1.5mg in April

      Got cocky and reduced to 1mg after only two weeks at start of May and after two weeks stopped altogether.

      BUT that was rushing it; believe it or not I had nasty withdrawal not helped by just getting over 'flu. 

      So...I'm back to 1mg and taking it gently.

      Patience and being gentle with yourself are the keys.

      Best wishes.

    • Posted

      Dear Sal,

      Thanks for the info. As you can see above, I more recently asked about crushing tablets at a compound chemist. I had this done, took a marginally reduced dose from 30mg to 27mg, using half a 30mg tablet and three customised 4mg ones (resulting in a 27mg total) and took that dose for a week and felt worse. Is crushing mirtazapine ok? Does it keep? If not, I'm interested in the liquid form (which we don't have in my country). How did you dissolve the tablet in water? Doesn't the enteric coating of the tablet get in the way? Is it safe to take it in that form? Is everything evenly distributed?

    • Posted

      Hello,   I have been prescribed the orodispersible tablets.   They dissolve on the tongue so they dissolve easily in water.  

      I dissolve one 15mg tablet in 15 ml. of water (1mg : 1ml) and suck up the required amount in a small syringe (no needle!) making sure to give it a good stir first.  I checked with my local pharmacist and he said it was a good way to reduce slowly.

      I'm currently on 2mg and leaving it for a few weeks before dropping by half a mg.  So far so good.

  • Posted

    Hi Katherine,

                          I have been looking for information on excactly what you have written about , im new to  posts  and wondered if you were still around to have a chat with as i see yours is over a year ago now . I am on 7.5 mg Mirtazipine and the doctor has given me the liquid form. I went to purchase the book you spoke about but it appears that the website cita has closed down and wondered if you knew of anywhere i could get one . Thank you

    Jane :-)

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