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Hi, I've been on this med for 18 months and Venlafaxine for 10 months and in this time I have put on 3 stone and have severe sweating everyday.

I'm now desperate to come off the mertazapine and am seeing doc tomorrow. Has anyone come off this med successfully and how did you do it?

Thanks x

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  • Posted

    You can try cold turkey julie but it is a way that is not full proof. There are people who go unscathed but there are a lot more who have withdrawals, and WD from Mirt is something actually.

    I am going by 1Mg lower each 10 - 15 days. my link is here....



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  • Posted

    I would recommend a very gradual reduction over a period of months. It took me four and a half months to come off mirtazapine from 30mg. I made a homemade liquid in order to titrate the final few mgs. Good luck. I have been free of it now since Mid February. I didn't find it very hard doing it very gradually but it was awful when I tried to come off it mmuch more quickly before that.

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  • Posted

    Medically, cessation of mirtazapine or any non-addictive AD does not cause true withdrawal. That doesn't mean it's fun, though. I went through an unpleasant discontinuation syndrome when quitting Paxil more than a decade ago. Took a few months to feel "right." Conversely, I quit 45mg of mirtazapine cold turkey a couple months ago and felt fine after maybe 10 days. Easy as pie, in comparison. And I took mirtazapine for 12 years.

    I went through benzo withdrawal years ago and THAT was hell on earth. And because I had to taper it down, it lasted almost a year. Stuff like benzos and opioids—truly addictive substances—those require a long taper to come off them without psychological and physical complications. Quitting benzos cold turkey can kill you. Quitting mirtazpaine cold turkey cannot.

    I would recommend taking a week or two off work if possible and trying quitting cold turkey, or taper down a quarter pill every few days. Ask your doctor for a couple week's worth of benzos to keep your rebound anxiety in check while going through disconinuation. (I managed to not have to take a single benzo, which I honestly didn't think I could do because I'm a bit of a baby when it comes to anxiety!)

    If after 5 days or so you don't feel better, then you can always try tapering instead. 

    My reasoning for this: I'd rather rip the bandaid off quickly and feel bad for a week or two, than taper my dosage every few weeks and feel awful for an entire year.

    Good luck!

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  • Posted

    Everyone is different Julie, there is no right or wrong way just the right way for you.  I have been following a slow taper of 10% every 4 weeks (or 5% every 2 weeks if super sensitive) as I couuldn't hack any faster due to terrible discontinuation symptoms.  It depends on the individuals' DNA, some can quit CT and not get a flicker of anx/insomnia/nausea/ibs etc ... some get all of them.  

    Maybe for an informed choice read the following, try 10% see how you feel firstly.

    For advice on tapering Mirtazapine slowly at the recommended rate of no more than 10% every 3 or 4 weeks, please see the following which is within this forum, 


    and then click on the link "REDUCING AD'S USING 10% WITHDRAWAL METHOD".   

    Liquid Mirt is available in the UK, Mirt Sol Tabs are available everywhere and can be used to make a liquid which can then be used to titrate evenly in smaller doses.

    Lots of advise to share on this forum, do your research, I never heard of anyone CT successfully other than MUD, who is so lucky to escape any suffering of stopping Mirt.

    Wishing you well.

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