Nausea and vomiting on Azathioprine
Posted , 11 users are following.
i was diagnosed with UC in April this year and currently taking prednisone and Azathioprine. My specialist is reducing my prednisone dose while slowly upping my Aza dose. I've been on Aza for 4 weeks now and things started off well but the last week I have started really bad nausea and vomiting which starts around 2 hours after I take the tablet and lasts for around 2-3 hours. I use to take the tablets in the morning after breakfast but due to the vomiting I changed to after dinner so it doesn't effect my work life. I always take after food but it doesn't seem to make a difference. Day 9 and I'm struggling and feel like I'm at breaking point. Has anyone else had a similar experience? My specialist has just suggested seeing if the side effects subside but I'm over it.
1 like, 19 replies
janet06428 Miss_uc2015
Posted
stephaney28634 Miss_uc2015
Posted
Skydriver Miss_uc2015
Posted
tony4455 Miss_uc2015
Posted
keifer13826 Miss_uc2015
Posted
terri13923 Miss_uc2015
Posted
Miss_uc2015 terri13923
Posted
yes I was also told a reaction would have started almost straight away but that wasn't my case. The day I stop taking it I stopped vomiting.
I don't get the sharp pains however I've been told by several doctors this is a common symptom of disease rather the medication. Either way I hope it eases for you.
stephaney28634 Miss_uc2015
Posted
terri13923 Miss_uc2015
Posted
jamie42145 terri13923
Posted
I get the same symptoms. Been on Aza 50mg for 12weeks along with what was my 4th period of prednisalone for crohns. The combination of the two worked great. But when my steroids ended my Aza dose was upped to 100mg. I've been on Aza on its own for a week and I'm really suffering. I've tried different times of day but no use. A few hours after taking them I get dizzy, nauseous and start vomiting but also accompanied by crippling abdominal pain high up that goes through to back ache. Back at the doctors next week where I think I'll have to ask for some gastro resistant tablets because I can't go on with this every day.
Jokuar Miss_uc2015
Posted
I had same symptoms again plus an awful flu-like lethargy.
I stopped and specialist put me on 6-Mercaptopurine instead. I've been taking this for 6 weeks and all OK at the moment.
Good luck
Pete
Miss_uc2015 Jokuar
Posted
Miss_uc2015 Jokuar
Posted
Jokuar Miss_uc2015
Posted
Sorry I didn't realise your original post was 3 months ago.
I don't have any nausea on 6MP but still get occasional headaches tiredness and bloating. These may just be part of the CD symptoms it's hard to know really.
I shall watch out for any changes around week 8/9 and keep my fingers crossed.
After reading some of the forums it appears we are both on a well recognised progression (from one medication to the next) though I'd rather not think about that too much whilst CD is in remission.
Wishing you good luck and health too
janeth54 Miss_uc2015
Posted
Jokuar janeth54
Posted
I had similar reaction to Aza after about 9 days and did try a brief break and retried (as IBD nurse recommended) and nausea etc came back again. So I was advised to stop the Aza.
As detailed above I've been on 6-MP ever since and so far so good.
Hope that helps
Pete
janeth54 Jokuar
Posted
Janet