NSAIDS and hypertension drugs
Posted , 6 users are following.
Any others here taking this combination of drugs?
I have had knee problems off and on for about seven years. Yesterday my doctor decided that my cartilage has finally 'Gone', probably finished by getting off our local trains where not only do you have to Mind the Gap but have a good two foot step down. He is arranging for another X-Ray prior to discussing my surgical options. Meantime he reluctantly prescribed an NSAID ( Naproxen) after considering my BP and past stomach ulcer and other problems.
Reading the packet insert it tells me that Losartan and most hypertensive drugs may be affected by how NSAIDS work.
Googling Naproxen + Losartan I read, "Significant interaction possible (monitoring by your doctor required).
losartan oral , naproxen oral . Either increases toxicity of the other by Other mechanism. Combination may reduce kidney function, particularly in elderly or volume depleted individuals.
naproxen oral decreases effects of losartan oral by opposing drug effects. Combination may reduce blood pressure reducing effect"
1 like, 55 replies
Jan999 derek76
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I have rheumatoid arthritis so need the anti inflammatory drug as well as Codeine but it could be depending on the next blood test that I will have to change one of the drugs because of the risk of kidney damage.
derek76 Jan999
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loxie Jan999
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joy47826 derek76
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derek76 joy47826
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naproxen oral decreases effects of atenolol oral by opposing drug effects. Associated with long term NSAID use (longer than 1 week). Blood pressure reducing effects may be reduced.
amlodipine-valsartan oral , naproxen oral . Either increases toxicity of the other by Other mechanism. Combination may reduce kidney function, particularly in elderly or volume depleted individuals.
eileen64__UK derek76
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I'm taking Naproxen but also have to take a stomach protector.....lansoprozol
I'm also taking BP meds once a day lercandipine {spelling??}
Love
Eileen UK
derek76 eileen64__UK
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MrsO-UK_Surrey derek76
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Although I haven't taken the Losartan/Naproxen combination, I did have to take Ibuprofen alongside Atenolol for several months some 8 years ago just to enable me to get off the bed and sometimes into a wheelchair and ambulance for hospital appointments when suffering from an, at-the-time, undiagnosed, inflammatory illness affecting all my muscles. I only took half the daily allowance of Ibuprofen gradually tapering down over about 7 months but at the end of that year, I had a call from the surgery following routine blood tests informing me that I had now got Chronic Kidney Disease Stage 3. This was an incredible shock to me owing to the fact that I have only had one kidney since the age of 12, and that kidney had not caused any trouble previously. I suspect that Ibuprofen was to blame, although there is a slight possibility that the undiagnosed and therefore untreated, inflammation in my body at the time could have contributed to the damage.
I think it is very worrying that combinations of drugs can be prescribed which can put us at risk - a good pharmacist is the best person to consult where drugs are concerned.
The extra worry for you with NSAIDs is obviously your history of stomach ulcer. Have you every tried eating a 'live' (probiotic) yoghurt as extra stomach protection?
derek76 MrsO-UK_Surrey
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The doctors use BNF to check on drugs but it does not go into enough detail unless they check for more information on Stockley's Interactions Checker. One of the pharmcists in the pharmacy I go to is very good at looking to see what other drugs I am taking and issue any warning. The others there don't.
When I used to use Boots I twice went back and questioned drug combinations that they had not warned me about. The Boots system evidently has records of all prescriptions ever issued to you at any branch. Once a pharmacist handed me my prescription and said 'You used to live in Edinburgh' I assumed that he had worked in a branch there but he said it came up on your records. I said that it could have been another person with the same name but he said it was the same date of birth. We have no privacy now!
I do take a live yoghurt.
joy47826 derek76
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Keeping the body more alkaline vs too acidic is important....carbs also keep inflammation thriving....too much meats....I am a meat eater but watch my portions.....fish and fish oils are good for inflammation and the heart. The beat goes on and there is much we need to do to help reduce inflammation....it takes work....
I'm just starting on a new systemic enzyme...I already take digestive enzymes, there is so much to learn on this subject...inflammation = pain.
MrsO-UK_Surrey derek76
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No definitely no privacy these days - Big Brother is watching!
I have been lucky to have two wonderful pharmacists in the area - unfortunately one has retired and the other was so good he was promoted to a bigger branch!
MrsO-UK_Surrey joy47826
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derek76 MrsO-UK_Surrey
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I qouted this on the statin conversation this morning.
Quote from an article in today's Daily Mail
"I think its a crusade, and if you are a believer you want everything to prove it right and you throw out anyone who disagrees with you"
He was actually referring to too little salt in peoples diet but it applies to most other research.
derek76 joy47826
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joy47826 derek76
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And there is a whole school of research out there that cholesterol is our friend and we need it and the drug industry makes all these drugs and then puts fear into everyone about the cholesterol issue....I do have a cholesterol post on the Alternative Board...it's all about money for the drug makers....sad but this is true...
My doc tests my homocysteine levels as I've gotten older as there is more research that higher homo levels are the heart's culprit. J
loxie joy47826
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derek76 loxie
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MrsO-UK_Surrey derek76
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I have felt quite concerned reading the scary posts about statins by Joy and Loxie. There could be vulnerable people reading these comments for whom statins are essential and it is quite possible that it could worry them so much that they might stop taking them.
I'm thinking of those people who have had heart attacks and strokes where statin treatment is protecting them from repeat events. Our son is one.
These forums are designed for people to help others from their experiences, not simply to scare others.
So we should all bear in mind that everyone is different
derek76 MrsO-UK_Surrey
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I posted elsewhere that a neighbour who comes from a family with a high death rate from heart disease is on statins and warfarin. He puts up with the side effects as he says the possible outcome of not taking them is worse.
loxie MrsO-UK_Surrey
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derek76 loxie
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loxie derek76
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derek76 loxie
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mayday35 loxie
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mayday35 derek76
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mayday35 MrsO-UK_Surrey
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loxie mayday35
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derek76 mayday35
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Vim and Ajax disappeared a few years ago from supermarkets but was still available in some small shops. It made a return to supermarkets but has gone again. When we ask they go and search and come back with a bottle of CIF and say that has replaced it.
The powder version of Flash as advertised by Molly Weir was great for washing paintwork and floors though deadly to my skin is now but a memory.
loxie derek76
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derek76 loxie
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Barbara Mullen was Janet the housekeeper in the original Doctor Findlay series. Annete Crosbie took over the role in the much later series. There is a B&B near us called Arden House, we always do Janet's phone voice as we pass it.
Did you ever read Cronin's other book on doctors The Citadel? The story of a Scottish doctor in a Welsh mining village who graduates and initially succumbs to the charlatans of Harley Street before returning to his roots.
"The Citadel is a novel by A. J. Cronin, first published in 1937, which was groundbreaking with its treatment of the contentious theme of medical ethics. It has been credited with laying the foundation in Great Britain for the introduction of the NHS a decade later"